Box-Behnken response surface modeling assisted enantiomeric resolution of some racemic β-blockers using HPTLC and β-cyclodextrin as chiral mobile phase additive: Application to check the enantiomeric purity of betaxolol

Chirality ◽  
2018 ◽  
Vol 30 (11) ◽  
pp. 1195-1205
Author(s):  
Eman I. El-Kimary ◽  
Marwa A.A. Ragab
Keyword(s):  
Response Surface ◽  
Mobile Phase ◽  
Surface Modeling ◽  
Enantiomeric Purity ◽  
Response Surface Modeling ◽  
Enantiomeric Resolution ◽  
Chiral Mobile Phase Additive ◽  
Mobile Phase Additive ◽  
Β Blockers

scholarly journals Enantioselective Chromatographic Analysis of Formoterol Fumarate using Chiral Mobile Phase Additives and Achiral Core-Shell Column

2020 ◽  
Author(s):  
Pranav Pathak ◽  
Krishnapriya Mohanraj
Keyword(s):  
Mobile Phase ◽  
Cost Effective ◽  
Hplc Method ◽  
Enantiomeric Resolution ◽  
Factors Affecting ◽  
Mobile Phase Additives ◽  
Ich Guidelines ◽  
Chiral Mobile Phase Additive ◽  
Mobile Phase Additive ◽  
Chiral Mobile Phase Additives

<p>A simple, robust, cost-effective, and rapid RP-HPLC method was developed for the separation of enantiomers of formoterol. The separation was achieved by the chiral mobile phase additive technique on an achiral column. Formoterol is a bronchodilator that consists of 50:50 S, S-formoterol and R, R-formoterol. The bronchodilator activity is attributed to R, R-formoterol. Hence, it is important to develop a method to separate the enantiomers of formoterol. Various factors affecting enantiomeric resolution were investigated and optimized. The enantiomers of formoterol were successfully separated with a resolution of 2.57 with a run-time of 9 minutes. The method was validated in accordance with ICH guidelines. The validated method was successfully applied to the marketed formulation of arformoterol. </p>

scholarly journals Enantioselective Chromatographic Analysis of Formoterol Fumarate using Chiral Mobile Phase Additives and Achiral Core-Shell Column

2020 ◽  
Author(s):  
Pranav Pathak ◽  
Krishnapriya Mohanraj
Keyword(s):  
Mobile Phase ◽  
Cost Effective ◽  
Hplc Method ◽  
Enantiomeric Resolution ◽  
Factors Affecting ◽  
Mobile Phase Additives ◽  
Ich Guidelines ◽  
Chiral Mobile Phase Additive ◽  
Mobile Phase Additive ◽  
Chiral Mobile Phase Additives

<p>A simple, robust, cost-effective, and rapid RP-HPLC method was developed for the separation of enantiomers of formoterol. The separation was achieved by the chiral mobile phase additive technique on an achiral column. Formoterol is a bronchodilator that consists of 50:50 S, S-formoterol and R, R-formoterol. The bronchodilator activity is attributed to R, R-formoterol. Hence, it is important to develop a method to separate the enantiomers of formoterol. Various factors affecting enantiomeric resolution were investigated and optimized. The enantiomers of formoterol were successfully separated with a resolution of 2.57 with a run-time of 9 minutes. The method was validated in accordance with ICH guidelines. The validated method was successfully applied to the marketed formulation of arformoterol. </p>

Diethyl Phthalate Removal by Continuous-Flow Ozonation: Response Surface Modeling and Optimization

2013 ◽  
Vol 224 (4) ◽  
Author(s):  
Marius Sebastian Secula ◽  
Yvan Barrot ◽  
Benoit Cagnon ◽  
Frederic Versaveau ◽  
Olivier Chedeville
Keyword(s):  
Response Surface ◽  
Continuous Flow ◽  
Surface Modeling ◽  
Diethyl Phthalate ◽  
Response Surface Modeling ◽  
Modeling And Optimization
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