Tricycloundecane Derivatives as PotentialN-Methyl-D-aspartate (NMDA) Receptor and Voltage-Gated Calcium Channel Modulators

ChemMedChem ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. 1259-1266 ◽  
Author(s):  
Ayodeji O. Egunlusi ◽  
Sarel F. Malan ◽  
Jacques Joubert
Keyword(s):  
Nmda Receptor ◽  
Calcium Channel ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel

Alteration in the phosphorylation status of NMDA receptor GluN2B subunit by activation of both NMDA receptor and L-type voltage gated calcium channel

2019 ◽  
Vol 709 ◽  
pp. 134343
Author(s):  
Mantosh Kumar ◽  
Mathew John ◽  
Mayadevi Madhavan ◽  
Jackson James ◽  
Ramakrishnapillai V. Omkumar
Keyword(s):  
Nmda Receptor ◽  
Calcium Channel ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel

Adamantane amine derivatives as dual acting NMDA receptor and voltage-gated calcium channel inhibitors for neuroprotection

MedChemComm ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 1678-1684 ◽  
Author(s):  
Yakub E. Kadernani ◽  
Frank T. Zindo ◽  
Erika Kapp ◽  
Sarel F. Malan ◽  
Jacques Joubert
Keyword(s):  
Nmda Receptor ◽  
Calcium Channel ◽  
Voltage Gated ◽  
Inhibitory Activities ◽  
Calcium Channel Inhibitors ◽  
Voltage Gated Calcium Channel

A series of adamantane-derived compounds, structurally similar to NGP1-01, were synthesised and showed significant dual NMDA receptor and VGCC inhibitory activities.

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