scholarly journals The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes

ChemMedChem ◽  
2020 ◽  
Vol 15 (24) ◽  
pp. 2388-2390
Author(s):  
Jean Quancard ◽  
Brian Cox ◽  
Dirk Finsinger ◽  
Stéphanie M. Guéret ◽  
Ingo V. Hartung ◽  
...  
Keyword(s):  
Best Practice ◽  
Medicinal Chemistry ◽  
European Federation ◽  
Chemical Probes

The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery

ChemMedChem ◽  
2021 ◽  
Author(s):  
Jean Quancard ◽  
Anders Bach ◽  
Brian Cox ◽  
Russell Craft ◽  
Dirk Finsinger ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Chemical Biology ◽  
Best Practice ◽  
Medicinal Chemistry ◽  
European Federation

scholarly journals An overview of EFLM harmonization activities in Europe

2018 ◽  
Vol 56 (10) ◽  
pp. 1591-1597 ◽  
Author(s):  
Eric S. Kilpatrick ◽  
Sverre Sandberg
Keyword(s):  
Best Practice ◽  
Clinical Chemistry ◽  
Laboratory Medicine ◽  
Biological Variation ◽  
European Federation ◽  
Eu Countries ◽  
European Guidelines ◽  
Common Basis ◽  
Evaluation Procedures ◽  
E Learning

Abstract The European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has initiated many harmonization activities in all phases of the examination process. The EFLM is dealing with both the scientific and the educational aspects of harmonization, with the intention of disseminating best practice in laboratory medicine throughout Europe. Priorities have been given (1) to establish a standard for conducting and assessing biological variation studies and to construct an evidence based EFLM webpage on biological variation data, (2) to harmonize preanalytical procedures by producing European guidelines, (3) to improve test ordering and interpretation, (4) to produce other common European guidelines for laboratory medicine and play an active part in development of clinical guidelines, (5) to establish a common basis for communicating laboratory results to patients, (6) to harmonize units of measurement throughout Europe, (7) to harmonize preanalytical procedures in molecular diagnostics and (8) to harmonize and optimize test evaluation procedures. The EFLM is also now launching the 5th version of the European Syllabus to help the education of European Specialists in Laboratory Medicine (EuSpLM), which is being supported by the development of e-learning courses. A register of EuSpLM is already established for members of National Societies in EU countries, and a similar register will be established for specialists in non-EU countries.

scholarly journals Negative controls of chemical probes can be misleading

2020 ◽  
Author(s):  
Jinyoung Lee ◽  
Matthieu Schapira
Keyword(s):  
Best Practice ◽  
Confounding Factor ◽  
Protein A ◽  
Negative Control ◽  
The Other ◽  
Chemical Probes ◽  
Intended Target ◽  
Simple Chemical ◽  
Cell Assays ◽  
Negative Controls

ABSTRACTChemical probes are selective modulators that are used in cell assays to link a phenotype to a gene and have become indispensable tools to explore gene function and discover therapeutic targets. While binding to off-targets can be acceptable or beneficial for drugs, it is a confounding factor for chemical probes, as the observed phenotype may be driven by inhibition of an unknown off-target instead of the targeted protein. A negative control – a close chemical analog of the chemical probe that is inactive against the intended target – is typically used to verify that the phenotype is indeed driven by targeted protein. Here, we compare the selectivity profiles of four unrelated chemical probes and their respective negative controls and find that the control is sometimes inactive against up to 80% of known off-targets, suggesting that a lost phenotype upon treatment with the negative control may be driven by loss of inhibition of the off-target. To extend this analysis, we inspect the crystal structures of 90 pairs of unrelated proteins, where both proteins within each pair is in complex with the same drug-like ligand, and estimate that in 50% of cases, methylation (a simple chemical modification often used to generate negative controls) of the ligand at a position that will preclude binding to one protein (intended target) will also preclude binding to the other (off-target). These results uncover a risk associated with the use of negative controls to confirm gene-phenotype associations. We propose that a best practice should rather be to verify that two chemically unrelated chemical probes targeting the same protein lead to the same phenotype.Abstract Figure

Supervision Of International Medical Graduates

2016 ◽  
Vol 33 (S1) ◽  
pp. S435-S435
Author(s):  
M. Casanova Dias ◽  
O. Andlauer ◽  
S. Dave
Keyword(s):  
Host Country ◽  
Best Practice ◽  
Early Career ◽  
International Medical ◽  
European Federation ◽  
International Medical Graduates ◽  
Host Countries ◽  
Clinical Placements ◽  
Medical Graduates ◽  
The Uk

IntroductionDoctors qualified outside the UK constitute > 40% workforce in psychiatry. Differential examinations’ attainment and poor career progression are key issues for International Medical Graduates (IMGs). Due to increased migration, this is transversal to many countries. Varying ethical standards and values in different countries can create difficulties in the workplace and impact quality of patient-care.ObjectivesTo understand current support available for IMGs across countries; identify areas of best practice.MethodsWe ran a preliminary open consultation to establish which initiatives were available across Europe and worldwide to address IMGs’ training abroad impact on their training/work in the host country and if any support exists for supervisors of IMGs. Representatives of European trainees were contacted through European Federation of Psychiatric Trainees network and early career psychiatrists through World Psychiatric Association network. Emphasis was given to identified host countries of IMGs.ResultsNo specific initiatives were identified in Europe. Out of the six main host countries – Denmark, Finland, Norway, Sweden, Switzerland, UK – one did not provide information. Many countries reported specific requirements for a doctor to be accepted to work. There are courses on language and medicolegal processes. Some support is available for doctors doing short clinical placements. However, once an IMG has been accepted to work in the host country, there is no special support given by way of supervision.ConclusionsReports suggest IMGs welcome initiatives to help them gain skills related to the system, its culture, and appreciate feedback on their performance. There is a need to help host countries better support IMGs.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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