european guidelines
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2022 ◽  
Vol 13 (1) ◽  
pp. 25
Author(s):  
Ylber Aliu

The main purpose of this paper is to study the new governance in the European Union: the open method of coordination (hereinafter: OMC). Some of the main features of the OMC are: an instrument of spreading the best practices of achieving the EU's main goals; to help member states develop their policies; creating a calendar for achieving project goals: short, medium and long term; translating European guidelines into national and regional policies specifying objectives and measures; as well as periodic monitoring and evaluation. The main value of the OMC is all involvement in decision-making: European Union institutions, civil society, interest groups, media, etc., through the OMC play a role in the process of drafting public policies and monitoring and evaluating implementation. The OMC aims to complement the 'democratic deficit' of EU institutions, especially in the education policy, employment policies and social welfare policies. We have used two methods for research of the paper. The first, the method of research of scientific and academic literature related to the European Union. Second, the case study of individual cases for displaying the new governance format: OMC in the European Union. The result of the research is to understand what new governance in the European Union is, when it comes to expression of this form of governance, who are the main actors in implementing new governance, when it has started to apply, etc. The conclusion of the paper is that the new governance in the European Union: the OMC has transformed the decision-making process as well as the process of drafting policies, strategies and legislation within the EU.   Received: 26 October 2021 / Accepted: 15 December 2021 / Published: 5 January 2022


Author(s):  
Ignacio Alvarez de Toledo ◽  
Jessica DeLong

Female urethral stricture (FUS) is a rare condition. It was not studied robustly for many years, but interest has grown recently in the reconstructive urology community, leading to an increase in publications. In this review, we gather the latest data regarding FUS and its different therapeutic options. Studies are summarized, split by technique. We also review the recently published European Guidelines. In addition, we share our preferred surgical technique and our views on future options. Diagnosing FUS can often be challenging and requires a high index of clinical suspicion. Its vague clinical symptoms and empiric initial treatments combine to make FUS an underdiagnosed condition. The lack of consensus on how to define FUS also compounds the problem. Appropriate diagnosis requires thorough investigation, and ancillary studies such as video urodynamics, cystoscopy, and voiding cystourethrogram may be useful. Treatment options range from conservative management to definitive procedures, although studies have shown that conservative measures such as urethral dilation have a low success rate overall. Within definitive management, augmented urethroplasty - using either flaps or grafts, has proven to be the gold standard. Both have shown excellent results over time; however, there is insufficient data available to recommend one over the other. Contemporary data has an overall poor level of evidence. Although challenging due to the rarity of the problem, a proper randomized controlled clinical trial comparing the principal surgical options and their outcomes would be beneficial and would allow for more informed decision making when considering options for women with urethral stricture.


2021 ◽  
Vol 11 (1) ◽  
pp. 132
Author(s):  
Eleni Diamanti ◽  
Vasiliki Karava ◽  
Patrick Yerly ◽  
John David Aubert

Carbon monoxide diffusion capacity (DLCO) is negatively associated with patient survival in idiopathic pulmonary hypertension (PH), but is not included in the risk stratification score proposed by the 2015 European guidelines. Since 2015, several new stratification scores based on a 3- or 4-severity scale have been explored. This retrospective cohort single-center study sought to investigate the association between DLCO and PH severity and survival. We included 85 treatment-naive patients with precapillary PH and DLCO measurement at diagnosis. DLCO status, based on lower and upper quartiles ranges, was added to a 3- and a 4-strata modified-risk assessment. DLCO was strongly associated with transplant-free survival (HR 0.939, 95% CI: 0.908–0.971, p < 0.001). In the intermediate and high-risk categories, DLCO was associated with transplant-free survival, irrespective of the risk category (HR 0.934, 95% CI: 0.880–0.980, p = 0.005). The correlation between modified-risk category and transplant-free survival was significant (HR 4.60, 95% CI: 1.294–16.352, p = 0.018). Based on the Akaike information criterion (AIC) levels, the 3- and 4-strata modified-risk stratification fits our results better than the conventional stratification. Low DLCO is associated with patient transplant-free survival, independently of the risk category. Inclusion of DLCO into a PH risk stratification score seems promising and needs further investigation.


Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 115
Author(s):  
Petra Vinklerová ◽  
Petra Ovesná ◽  
Markéta Bednaříková ◽  
Luboš Minář ◽  
Michal Felsinger ◽  
...  

Background: Endometrial cancer is the most common gynecological malignancy in developed countries with no screening available. There is still a tendency to provide invasive bioptic verification in asymptomatic women with abnormal ultrasound findings to diagnose carcinoma in a preclinical phase; even though, it is not supported by European guidelines. Our goal was to determine DFS (disease-free survival), OS (overall survival), and DSS (disease-specific survival) differences between symptom-free and symptomatic (bleeding, or spotting) endometrial cancer patients with similar stage and tumor/clinical characteristics. Methods: All of our patients with endometrial cancer following surgical treatment between 2006 and 2019 were assessed, evaluating risk factors for recurrence and death while focusing on bleeding using univariable and multivariable analysis. Results: 625 patients meeting the inclusion criteria were divided into asymptomatic (n = 144, 23%) and symptomatic (n = 481, 77%) groups. The median follow-up was 3.6 years. Using univariable analysis, symptomatic patients had a three times higher risk of recurrence (HR 3.1 (95% Cl 1.24–7.77), p = 0.016). OS (HR 1.35 (0.84–2.19), p = 0.219) and DSS (HR 1.66 (0.64–4.28), p = 0.3) were slightly worse without reaching statistical significance. In our multivariable analysis, symptomatology was deemed completely insignificant in all monitored parameters (DFS: HR 2.03 (0.79–5.24), p = 0.144; OS: HR 0.72 (0.43–1.21), p = 0.216). Conclusions: The symptomatic endometrial cancer patients risk factor of earlier recurrence and death is insignificantly higher when compared with the asymptomatic cohort. However, multivariable analysis verifies that prognosis worsens with other clinically relevant parameters, not by symptomatology itself. In terms of survival outcome in EC patients, we recognized symptomatology as a non-significant marker for the patient’s prognosis.


Author(s):  
Anja Almén ◽  
Jónína Guðjónsdóttir ◽  
Nils Heimland ◽  
Britta Højgaard ◽  
Hanne Waltenburg ◽  
...  

Objective: The purpose of this study was to explore the feasibility to determine regional diagnostic reference levels (RDRLs) for paediatric conventional and CT examinations using the European guidelines and to compare RDRLs derived from weight and age groups, respectively. Methods: Data were collected from 31 hospitals in 4 countries, for 7 examination types for a total of 2978 patients. RDRLs were derived for each weight and age group, respectively, when the total number of patients exceeded 15. Results: It was possible to derive RDRLs for most, but not all, weight-based and age-based groups for the seven examinations. The result using weight-based and age-based groups differed substantially. The RDRLs were lower than or equal to the European and recently published national DRLs. Conclusion: It is feasible to derive RDRLs. However, a thorough review of the clinical indications and methodologies has to be performed previous to data collection. This study does not support the notion that DRLs derived using age and weight groups are exchangeable. Advances in knowledge: Paediatric DRLs should be derived using weight-based groups with access to the actual weight of the patients. DRLs developed using weight differ markedly from those developed with the use of age. There is still a need to harmonize the method to derive solid DRLs for paediatric radiological examinations.


Author(s):  
Katariina Laine ◽  
Branka M. Yli ◽  
Vanessa Cole ◽  
Christiane Schwarz ◽  
Anneke Kwee ◽  
...  

2021 ◽  
pp. 1-16
Author(s):  
Ângela Maria Vilaça Pereira de Araújo Pizarro ◽  
Maria Rosário O. Martins ◽  
Jorge Almeida Simões

In the last decade (2010–2020), more than half of European countries have improved their health policies within the primary care for type 2 <i>diabetes mellitus</i>. Community pharmacies have been and could continue to be essential actors in this evolution of fighting the disease by providing a set of pharmacotherapeutic follow-up services for the person with diabetes. These services, designated by the Pharmaceutical Group of the European Union as “<i>diabetes management</i>” and “<i>glucose measurement</i>”, have aimed to optimize adherence to therapy and improve health outcomes. However, to follow the European guidelines of Good Pharmacy Practice, providing these services implies having a normative framework or a legal basis. Thus, this study sought to analyze the normative and regulatory framework on which community pharmacies in 28 European countries were based on providing this health care over the last decade.


2021 ◽  
Vol 14 (12) ◽  
pp. 1253
Author(s):  
Zuzanna Łucja Babalska ◽  
Marzena Korbecka-Paczkowska ◽  
Tomasz M. Karpiński

Issues arising in wound healing are very common, and chronic wound infections affect approximately 1.5% of the population. The main substances used in wound washing, cleansing and treatment are antiseptics. Today, there are many compounds with a known antiseptic activity. Older antiseptics (e.g., boric acid, ethacridine lactate, potassium permanganate, hydrogen peroxide, iodoform, iodine and dyes) are not recommended for wound treatment due to a number of disadvantages. According to the newest guidelines of the Polish Society for Wound Treatment and the German Consensus on Wound Antisepsis, only the following antiseptics should be taken into account for wound treatment: octenidine (OCT), polihexanide (PHMB), povidone-iodine (PVP-I), sodium hypochlorite (NaOCl) and nanosilver. This article provides an overview of the five antiseptics mentioned above, their chemical properties, wound applications, side effects and safety.


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