BrJAC mourns the death of Prof. Dr. Miguel Valcárcel Cases and recognizes his great contribution to Analytical Chemistry and Science around the World

Who has not seen or heard about books such as Analytical Chemistry: A Modern Approach to Analytical Science, Principles of Analytical Chemistry: A Textbook, or Foundations of Analytical Chemistry: A Teaching-Learning Approach, or about flow injection analysis-FIA, and sequential injection analysis-SIA? These are, in fact, some contributions from Prof. Miguel Valcárcel Cases, at the University of Córdoba-Spain, who leave us on 9th January 2022 at the age of 75. Prof. Valcárcel was Dean of the Faculty of Sciences at the University of Córdoba, Vice-Rector for academic guidance and teaching and Vice-Rector for quality, as well as the first Director of the Andalusian Institute of Fine Chemistry and Nanochemistry since 1994. Born in Barcelona (Spain), Prof. Valcárcel was a graduate of the University of Seville where also obtained his Ph.D., and was an assistant teacher until 1975. He was an associate professor of Analytical Chemistry at the Faculty of Science of Palma de Mallorca in 1975, an institution where he was also Dean and full professor at the University of Cordoba in the year 1976. He was also President of the Analytical Division of the European Federation of Chemical Societies and was a member for 4 years of the High-Level Expert Group of the European Union's Growth Program. Valcárcel received the Spanish national Enrique Moles prize for Chemical Science and Technology (2005), the Maimónides prize for scientific-technical research from the Junta de Andalucia (1992), and the Solvay Research Prize in Chemical Sciences from the CEOE Foundation (1997). He has the Robert Boyle Medal from the Royal Society of Chemistry (UK, 2004), the Enrich Planquette Prize from the Austrian Chemical Society (1996), the Gold Medal from the University of Warsaw (2000), and the Medal from the Portuguese Chemical Society (2000). He also received the distinction of Cordoba citizen of the year 2006 in the education/research section, and the Averroes de Oro-Cuidad de Córdoba medal in 2006 for his scientific trajectory. He was also awarded the title of Doctor Honoris Causa by the University of Valencia (2010) and the European DAC-EuChMS (Division of Analytical Chemistry of the European Association for Chemical and Molecular Sciences) award in recognition of his scientific and teaching career (2015). He was the author of ca. 700 papers, published 9 scientific books, and co-authored 15 chapters of multi-author books. Owner of a unique vitality and a very accurate vision of Analytical Chemistry, Prof. Valcárcel contributed to the formation of dozens of students, of which he was extremely proud, and some of them are today Full professors spread all over the world. The Brazilian Journal of Analytical Chemistry mourns his death, and through this simple tribute, recognizes his great contribution to Analytical Chemistry and science around the world.

Oligocat: Oligoesters as Pseudo-Homogenous Catalysts for Biodiesel Synthesis

Biodiesel production from first-generation feedstock has shown a strong correlation with the increase in deforestation and the necessity of larger areas for land farming. Recent estimation from the European Federation for Transport and Environment evidenced that since the 2000s decade, an area equal to the Netherlands was deforested to supply global biodiesel demand, mainly originating from first-generation feedstock. Nevertheless, biodiesel is renewable, and it can be a greener source of energy than petroleum. A promising approach to make biodiesel independent from large areas of farming is to shift as much as possible the biodiesel production chain to second and third generations of feedstock. The second generation presents three main advantages, where it does not compete with the food industry, its commercial value is negligible, or none, and its usage as feedstock for biodiesel production reduces the overall waste disposal. In this manuscript, we present an oligomeric catalyst designed to be multi-functional for second-generation feedstock transesterification reactions, mainly focusing our efforts to optimize the conversion of tallow fat and sauteing oil to FAME and FAEE, applying our innovative catalyst. Named as Oligocat, our catalyst acts as a Brønsted-Lowry acid catalyst, providing protons to the reaction medium, and at the same time, with the course of the reaction, it sequesters glycerol molecules from the medium and changes its physical phase during the transesterification reaction. With this set of properties, Oligocat presents a pseudo-homogenous behavior, reducing the purification and separation steps of the biodiesel process production. Reaction conditions were optimized applying a 42 factorial planning. The output parameter evaluated was the conversion rate of triacylglycerol to mono alkyl esters, measured through gel permeation chromatography (GPC). After the optimization studies, a conversion yield of 96.7 (±1.9) wt% was achieved, which allows classifying the obtained mono alkyl esters as biodiesel by ASTM D6751 or EN 14214:2003. After applying the catalyst in three reaction cycles, Oligocat still presented a conversion rate above 96.5 wt% and as well an excellent recovery rate.

Sour Environmental Severity for HIC Susceptibility

The severity of sour environments has been determined in accordance with the European Federation of Corrosion 16 and NACE MR0175/ISO 15156-2:2015 standards for carbon and low-alloy steels, based on the experimental results of sulfide stress cracking (SSC). However, the severity map obtained from SSC test results cannot be applicable to the hydrogen-induced cracking (HIC) susceptibility. In this study, the hydrogen permeability and crack area ratio (CAR) of HIC under various pH and H2S partial pressures (pH2S) were measured to establish the link between the sour environmental severity and HIC susceptibility using grades X65 to X80 linepipe steels. In addition, the hydrogen concentration at the location of the HIC was calculated by the finite element analysis. The results showed that the sour environmental severity map obtained from hydrogen permeation tests changes with time, because the hydrogen permeability reached maximum values in the early stage and steady-state values in the later stage. Then, the HIC susceptibility did not correspond to the maximum permeability, but to the steady-state hydrogen permeability. In addition, the hydrogen content at the location of the HIC did not correspond to the maximum hydrogen permeability but corresponded to the steady-state hydrogen permeability, because HIC occurred in the center segregation part and the hydrogen atoms required a certain time to diffuse from the metal surface to the mid-thickness. These results suggest that the HIC susceptibility is dominated by the severity map obtained from the steady-state hydrogen permeability.

A possible review by the European ministry of education in 2050—by a reluctant manager of Europe’s path towards educational dependency

Murat Adam is head of policy and curriculum for the European ministry of education. Political pressure is rising. Media channels across the European federation are labeling the continent as the most recent member of the education periphery. In Mr Adam’s world, curricular authority transpires from the big 3, the North American Union (NAU), China, and Russia. Credibility and endorsement are educational currencies—institutional capital as Bourdieu once defined it, reigns. Mr Adam’s battle is already lost, member states of the European federation have lost their educational means of production, but he cannot afford to admit that. European teachers’ credentials increasingly force graduates into care taking jobs at digital day cares. These are a response to US teachers’ and practitioners’ revolts of the late 20s, linked to perceived multisensory impoverishment of digitally schooled children. Just like in South Asia, Africa, and South America, digital day cares merely provide the digital and social framework and setup K-12 students to listen to internationally accredited professionals teach from China, Russia, and the NAU. Day and night shifts are common. He knows that the European federation lost the contest, by the time it decided not to invest into its own internet infrastructure. The educational first world’s curricular authority would not have been possible without the three nations’ proprietary server architecture, which commodified bandwidth and connectivity. The internet of the past is nothing more than a front for the three de-facto mutually exclusive digital ecosystems, provided by China, the NAU, and Russia.

Accessibility and quality of drug company disclosures of payments to healthcare professionals and organisations in 37 countries: a European policy review

ObjectivesTo examine the accessibility and quality of drug company payment data in Europe.DesignComparative policy review of payment data in countries with different regulatory approaches to disclosure.Setting37 European countries.ParticipantsEuropean Federation of Pharmaceutical Industries and Associations, its trade group and their drug company members; eurosfordocs.eu, an independent database integrating payments disclosed by companies and trade groups; regulatory bodies overseeing payment disclosure.Main outcome measuresRegulatory approaches to disclosure (self-regulation, public regulation, combination of the two); data accessibility (format, structure, searchability, customisable summary statistics, downloadability) and quality (spectrum of disclosed characteristics, payment aggregation, inclusion of taxes, recipient or donor identifiers).ResultsOf 30 countries with self-regulation, five had centralised databases, with Disclosure UK displaying the highest accessibility and quality. In 23 of the remaining countries with self-regulation and available data, disclosures were published in the portable document format (PDF) on individual company websites, preventing the public from understanding payment patterns. Eurosfordocs.eu had greater accessibility than any industry-run database, but the match between the value of payments integrated in eurosfordocs.eu and summarised separately by industry in seven countries ranged between 56% and 100% depending on country. Eurosfordocs.eu shared quality shortcomings with the underlying industry data, including ambiguities in identifying payments and their recipients. Public regulation was found in 15 countries, used either alone (3), in combination (4) or in parallel with (8) self-regulation. Of these countries, 13 established centralised databases with widely ranging accessibility and quality, and sharing some shortcomings with the industry-run databases. The French database, Transparence Santé, had the highest accessibility and quality, exceeding that of Disclosure UK.ConclusionsThe accessibility and quality of payment data disclosed in European countries are typically low, hindering investigation of financial conflicts of interest. Some improvements are straightforward but reaching the standards characterising the widely researched US Open Payments database requires major regulatory change.

Determining Plasma Protein Variation Parameters as a Prerequisite for Biomarker Studies—A TMT-Based LC-MSMS Proteome Investigation

Specific plasma proteins serve as valuable markers for various diseases and are in many cases routinely measured in clinical laboratories by fully automated systems. For safe diagnostics and monitoring using these markers, it is important to ensure an analytical quality in line with clinical needs. For this purpose, information on the analytical and the biological variation of the measured plasma protein, also in the context of the discovery and validation of novel, disease protein biomarkers, is important, particularly in relation to for sample size calculations in clinical studies. Nevertheless, information on the biological variation of the majority of medium-to-high abundant plasma proteins is largely absent. In this study, we hypothesized that it is possible to generate data on inter-individual biological variation in combination with analytical variation of several hundred abundant plasma proteins, by applying LC-MS/MS in combination with relative quantification using isobaric tagging (10-plex TMT-labeling) to plasma samples. Using this analytical proteomic approach, we analyzed 42 plasma samples prepared in doublets, and estimated the technical, inter-individual biological, and total variation of 265 of the most abundant proteins present in human plasma thereby creating the prerequisites for power analysis and sample size determination in future clinical proteomics studies. Our results demonstrated that only five samples per group may provide sufficient statistical power for most of the analyzed proteins if relative changes in abundances >1.5-fold are expected. Seventeen of the measured proteins are present in the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Biological Variation Database, and demonstrated remarkably similar biological CV’s to the corresponding CV’s listed in the EFLM database suggesting that the generated proteomic determined variation knowledge is useful for large-scale determination of plasma protein variations.

European consensus on patient contact shielding

Patient contact shielding has been in use for many years in radiology departments in order to reduce the effects and risks of ionising radiation on certain organs. New technologies in projection imaging and CT scanning such as digital receptors and automatic exposure control systems have reduced doses and improved image consistency. These changes and a greater understanding of both the benefits and the risks from the use of shielding have led to a review of shielding use in radiology. A number of professional bodies have already issued guidance in this regard. This paper represents the current consensus view of the main bodies involved in radiation safety and imaging in Europe: European Federation of Organisations for Medical Physics, European Federation of Radiographer Societies, European Society of Radiology, European Society of Paediatric Radiology, EuroSafe Imaging, European Radiation Dosimetry Group (EURADOS), and European Academy of DentoMaxilloFacial Radiology (EADMFR). It is based on the expert recommendations of the Gonad and Patient Shielding (GAPS) Group formed with the purpose of developing consensus in this area. The recommendations are intended to be clear and easy to use. They are intended as guidance, and they are developed using a multidisciplinary team approach. It is recognised that regulations, custom and practice vary widely on the use of patient shielding in Europe and it is hoped that these recommendations will inform a change management program that will benefit patients and staff.