Preclinical data suggest role of dopamine in preventing select skin cancers

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.

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Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review

Life ◽

10.3390/life11040326 ◽

2021 ◽

Vol 11 (4) ◽

pp. 326

Author(s):

Magdalena Ciążyńska ◽

Irmina Olejniczak-Staruch ◽

Dorota Sobolewska-Sztychny ◽

Joanna Narbutt ◽

Małgorzata Skibińska ◽

...

Keyword(s):

Ultraviolet Radiation ◽

Chronic Inflammation ◽

Potential Role ◽

Tumor Formation ◽

Skin Carcinogenesis ◽

Molecular Networks ◽

Cancer Therapies ◽

Inflammatory Microenvironment ◽

Skin Cancers

The process of skin carcinogenesis is still not fully understood. Both experimental and epidemiological evidence indicate that chronic inflammation is one of the hallmarks of microenvironmental-agent-mediated skin cancers and contributes to its development. Maintaining an inflammatory microenvironment is a condition leading to tumor formation. Multiple studies focus on the molecular pathways activating tumorigenesis by inflammation and indicate several biomarkers and factors that can improve diagnostic and prognostic processes in oncology and dermatology. Reactive oxygen species produced by ultraviolet radiation, oxidizers, or metabolic processes can damage cells and initiate pro-inflammatory cascades. Considering the potential role of inflammation in cancer development and metastasis, the identification of early mechanisms involved in carcinogenesis is crucial for clinical practice and scientific research. Moreover, it could lead to the progress of advanced skin cancer therapies. We focus on a comprehensive analysis of available evidence and on understanding how chronic inflammation and ultraviolet radiation can result in skin carcinogenesis. We present the inflammatory environment as complex molecular networks triggering tumorigenesis and constituting therapeutic targets.

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A Case of Squamous Cell Carcinoma of Skin Subsequent to Subcutaneous Foreign Body

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v12i1.10604 ◽

2016 ◽

Vol 12 (1) ◽

pp. 53-55

Author(s):

P Anwar ◽

S Mubashir ◽

I Hassa ◽

T Arif

Keyword(s):

Squamous Cell Carcinoma ◽

Foreign Body ◽

Cell Carcinoma ◽

Squamous Cell ◽

Foreign Bodies ◽

Transposition Flap ◽

Skin Cancers ◽

Flap Closure ◽

Melanoma Skin

Squamous cell carcinoma (SCC) of the skin is one of the most common non melanoma skin cancers (NMSC), along with basal cell carcinoma (BCC). Besides ultraviolet radiation, the role of exposure to industrial agents, ionizing radiation and areas of chronic inflammation is associated with the development of SCC. SCC may also be associated with foreign bodies. We report a rare case of cutaneous SCC in an elderly Kashmiri female, developing subsequent to subcutaneous non metallic foreign body, which was successfully excised with negative margins, and transposition flap closure. DOI: http://dx.doi.org/10.3126/njdvl.v12i1.10604 Nepal Journal of Dermatology, Venereology & Leprology Vol.12(1) 2014 pp.53-55

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