Laminar organization of the pyramidal cell layer of the subiculum in the rat

2001 ◽  
Vol 435 (1) ◽  
pp. 89-110 ◽  
Author(s):  
Norio Ishizuka
Keyword(s):  
Pyramidal Cell ◽  
Cell Layer ◽  
Laminar Organization ◽  
Pyramidal Cell Layer

Accumulation of apolipoprotein E and β-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death

Neuroreport ◽  
1996 ◽  
Vol 7 (18) ◽  
pp. 3063-3068 ◽  
Author(s):  
Hirohisa Ishimaru ◽  
Koichi Ishikawa ◽  
Seiichi Haga ◽  
Mikio Shoji ◽  
Yoshihide One ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Pyramidal Cell ◽  
Neuronal Death ◽  
Cell Layer ◽  
Delayed Neuronal Death ◽  
Pyramidal Cell Layer ◽  
Hippocampal Ca1 ◽  
Β Amyloid

The Effects of Thiopental and Propofol on Cell Swelling Induced by Oxygen/Glucose Deprivation in the CA1 Pyramidal Cell Layer of Rat Hippocampal Slices

2002 ◽  
Vol 94 (3) ◽  
pp. 655-660 ◽  
Author(s):  
Sihua Qi ◽  
Ren-Zhi Zhan ◽  
Chaoran Wu ◽  
Hideyoshi Fujihara ◽  
Kiichiro Taga ◽  
...  
Keyword(s):  
Pyramidal Cell ◽  
Cell Layer ◽  
Hippocampal Slices ◽  
Glucose Deprivation ◽  
Cell Swelling ◽  
Oxygen Glucose Deprivation ◽  
Pyramidal Cell Layer

Estimators of the precision of stereological estimates: An example based on the CA1 pyramidal cell layer of rats

Neuroscience ◽  
2005 ◽  
Vol 136 (3) ◽  
pp. 757-767 ◽  
Author(s):  
L. Slomianka ◽  
M.J. West
Keyword(s):  
Pyramidal Cell ◽  
Cell Layer ◽  
Pyramidal Cell Layer

scholarly journals Estrogen is Neuroprotective via an Apolipoprotein E—Dependent Mechanism in a Mouse Model of Global Ischemia

2002 ◽  
Vol 22 (10) ◽  
pp. 1189-1195 ◽  
Author(s):  
Karen Horsburgh ◽  
I. Mhairi Macrae ◽  
Hilary Carswell
Keyword(s):  
Cerebral Ischemia ◽  
Apolipoprotein E ◽  
Caudate Nucleus ◽  
Pyramidal Cell ◽  
Cell Layer ◽  
Neuronal Damage ◽  
Global Ischemia ◽  
Pyramidal Cell Layer ◽  
17Β Estradiol ◽  
Deficient Mice

Estrogen can ameliorate brain damage in experimental models of focal cerebral ischemia. In vitro, estrogen increases levels of apolipoprotein E (apoE), which also has neuroprotective effects in brain injury. The authors tested the hypotheses that physiologically relevant levels of 17β-estradiol are neuroprotective in global cerebral ischemia and that neuroprotection is mediated via apoE. In the first study, subcutaneous implants of 17β-estradiol were tested in female C57Bl/6J mice (ovariectomized and nonovariectomized) and plasma levels measured by radioimmunoassay to validate that physiologically relevant levels could be achieved. In the second study, female C57Bl/6J and apoE-deficient mice were ovariectomized and implanted with 17β-estradiol or placebo pellet. Two weeks later, transient global ischemia was induced by bilateral carotid artery occlusion and the mice killed after 72 hours. Ischemic and normal neurons were counted in the caudate nucleus and CA1 pyramidal cell layer and the percentage of neuronal damage was compared between the treated groups. In C57Bl/6J mice, there was less neuronal damage in the 17β-estradiol-treated group compared with placebo group in the caudate nucleus (15 ± 20% versus 39 ± 27%, P = 0.02) and in the CA1 pyramidal cell layer (1.8 ± 2% versus 10 ± 14%, P = 0.08). In contrast, neuronal damage was not significantly different between the 17β-estradiol and placebo groups in apoE-deficient mice in the caudate nucleus (47 ± 35% versus 53 ± 29%, P = 0.7) or in the CA1 pyramidal cell layer (24 ± 19% versus 24 ± 19%, P = 1.0). The data indicate a neuroprotective role for estrogen in global ischemia, the mechanism of which is apoE-dependent.

scholarly journals Neuroprotection after Transient Global Cerebral Ischemia in Wlds Mutant Mice

2004 ◽  
Vol 24 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Thomas H. Gillingwater ◽  
Jane E. Haley ◽  
Richard R. Ribchester ◽  
Karen Horsburgh
Keyword(s):  
Cerebral Ischemia ◽  
Caudate Nucleus ◽  
Pyramidal Cell ◽  
Cell Layer ◽  
Neuronal Degeneration ◽  
Neuronal Damage ◽  
Global Cerebral Ischemia ◽  
Nerve Lesion ◽  
Wild Type ◽  
Pyramidal Cell Layer

The Wlds mouse mutant demonstrates a remarkable phenotype of delayed axonal and synaptic degeneration after nerve lesion. In this study, the authors tested the hypothesis that expression of Wld protein is neuroprotective in an in vivo mouse model of global cerebral ischemia. This model is associated with selective neuronal degeneration in specific brain regions such as the caudate nucleus and CA2 hippocampal pyramidal cell layer. The extent of neuronal damage was quantified in Wlds compared to wild-type mice after an identical episode of global cerebral ischemia. The results demonstrated a significant and marked reduction in the extent of neuronal damage in Wlds as compared to wild-type C57Bl/6 mice. In the caudate nucleus, Wld expression significantly reduced the percentage of ischemic neuronal damage after global ischemia (Wlds, 27.7 ± 16.8%; wild-type mice, 58.7 ± 32.3%; P = 0.036). Similarly, in the CA2 pyramidal cell layer, there was a significant reduction of neuronal damage in the Wlds mice as compared to wild-type mice after ischemia (Wlds, 17.7 ± 23.0%; wild-type mice, 41.9 ± 28.0%; P < 0.023). Thus, these results clearly demonstrate that the Wld gene confers substantial neuroprotection after cerebral ischemia, and suggest a new role to that previously described for Wlds.

The pyramidal cell layer of sector CA 1 shows the lowest hippocampal succinate dehydrogenase activity in normal and postischemic gerbils

1996 ◽  
Vol 206 (2-3) ◽  
pp. 117-120 ◽  
Author(s):  
Toshihiko Kuroiwa ◽  
Masahiro Terakado ◽  
Tokio Yarnaguchi ◽  
Shu Endo ◽  
Masato Ueki ◽  
...  
Keyword(s):  
Succinate Dehydrogenase ◽  
Dehydrogenase Activity ◽  
Pyramidal Cell ◽  
Cell Layer ◽  
Succinate Dehydrogenase Activity ◽  
Pyramidal Cell Layer

scholarly journals Calbindin immunostaining in the CA1 hippocampal pyramidal cell layer of the human and mouse: A comparative study

2020 ◽  
Vol 104 ◽  
pp. 101745 ◽  
Author(s):  
Paula Merino-Serrais ◽  
Silvia Tapia-González ◽  
Javier DeFelipe
Keyword(s):  
Comparative Study ◽  
Pyramidal Cell ◽  
Cell Layer ◽  
Hippocampal Pyramidal Cell ◽  
Pyramidal Cell Layer ◽  
Human And Mouse
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