Reduced order methods for parametric optimal flow control in coronary bypass grafts, toward patient‐specific data assimilation

In this work we will focus on recent advances in reduced order modelling for parametrized problems in computational fluid dynamics, with a special attention to the case of inverse problems, such as optimal flow control problems and data assimilation, and multi-physics applications. Among the former, we will discuss applications arising in environmental marine sciences and engineering, namely a pollutant control in the Gulf of Trieste, Italy and a solution tracking governed by quasi-geostrophic equations describing North Atlantic Ocean dynamic. Similar methodologies will also be employed in problems related to the modeling of the cardiovascular system. Among the latter, we will present further recent developments on reduction of fluid-structure interaction problems, based on our earlier work. Reduced order approaches for parametric optimal flow control will also be applied in combination with domain decomposition in view of further applications in multi-physics. This work is in collaboration with Y. Maday (UPMC Université Paris 06, France), L. Jiménez-Juan (Sunnybrook Health Sciences Centre, Toronto, Canada), P. Triverio (University of Toronto, Canada), R. Mosetti (National Institute of Oceanography and Applied Geophysics, Trieste, Italy).

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Coronary Bypass Grafts: Assessment of Critical 3-D Anatomic Features

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84305-7 ◽

1998 ◽

Vol 31 (2) ◽

pp. 139A ◽

Cited By ~ 1

Author(s):

J Carroll

Keyword(s):

Coronary Bypass ◽

Bypass Grafts ◽

Coronary Bypass Grafts

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Delayed Progression of Atherosclerosis in Coronary Bypass Grafts Is Similar in Women Compared to Men Following Aggressive Cholesterol Lowering Despite More Frequent Risk Factors: Post CABG Trial

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84929-7 ◽

1998 ◽

Vol 31 (2) ◽

pp. 280A-281A ◽

Cited By ~ 1

Author(s):

L Campeau

Keyword(s):

Risk Factors ◽

Coronary Bypass ◽

Bypass Grafts ◽

Cholesterol Lowering ◽

Coronary Bypass Grafts ◽

Progression Of Atherosclerosis

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Biodegradable small calibre polydioxanone-based vascular prostheses: Potential as coronary bypass grafts

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-2008-1037921 ◽

2008 ◽

Vol 56 (S 1) ◽

Author(s):

B Walpoth ◽

M Cikirikcioglu ◽

D Mugnai ◽

JC Tille ◽

E Pektok ◽

...

Keyword(s):

Coronary Bypass ◽

Bypass Grafts ◽

Vascular Prostheses ◽

Coronary Bypass Grafts

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Blood Flow Pattern and Anastomotic Compliance for Interrupted versus Continuous Coronary Bypass Grafts

The Heart Surgery Forum ◽

10.1532/hsf.740 ◽

2005 ◽

Vol 6 (2) ◽

pp. 65 ◽

Cited By ~ 14

Author(s):

Marc Gerdisch ◽

Thomas Hinkamp ◽

Stephen D. Ainsworth

Keyword(s):

Blood Flow ◽

Vessel Wall ◽

Coronary Bypass ◽

Bypass Grafts ◽

Cross Sectional ◽

Coronary Bypass Grafts ◽

Geometric Consistency ◽

Suturing Technique ◽

Suturing Techniques ◽

Key Indicators

Background: Use of the interrupted coronary anastomosis has largely been abandoned in favor of the more rapid continuous suturing technique. The Coalescent U-CLIP anastomotic device allows the surgeon to create an interrupted distal anastomosis in the same amount of time that it would take to create a continuous anastomosis. This acute bovine study examined the effect of the anastomotic technique on blood flow and vessel wall function. Methods: End-to-side coronary anastomoses were created in an open chest bovine model using the left and right internal thoracic arteries and the left anterior descending coronary artery. All other variables except suturing technique were carefully controlled. In each animal, one anastomosis was completed using a continuous suturing technique and the other was performed in an interrupted fashion using the Coalescent U-CLIP anastomotic device. Volumetric flow curves through each graft were analyzed using key indicators of anastomotic quality, and anastomotic compliance was evaluated using intravascular ultrasound. Luminal castings were created of each vessel to examine the interior surface of each anastomosis for constrictions and deformities. Results: The interrupted anastomoses created with the Coalescent U-CLIP anastomotic device showed significant differences with respect to anastomotic compliance, pulsatility index, peak flow, and percentage of diastolic flow. The cross-sectional area and degree of luminal deformity were also different for the two suturing techniques. Conclusions: In this acute bovine model, interrupted coronary anastomoses demonstrated superior geometric consistency and greater physiologic compliance than did continuously sutured anastomoses. The interrupted anastomosis also caused fewer disturbances to the flow waveform, behaving similarly to a normal vessel wall. The combination of these effects may influence both acute and long-term patency of the coronary bypass grafts.

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