Overview of Genetically Engineered Mouse Models of Prostate Cancer and Their Applications in Drug Discovery

2018 ◽  
Vol 81 (1) ◽  
pp. e39 ◽  
Author(s):  
Gianluca Civenni ◽  
Giuseppina M. Carbone ◽  
Carlo V. Catapano
Keyword(s):  
Prostate Cancer ◽  
Drug Discovery ◽  
Mouse Models ◽  
Genetically Engineered ◽  
Genetically Engineered Mouse Models

Genetically Engineered Mouse Models in Drug Discovery Research

2009 ◽  
pp. 37-54 ◽  
Author(s):  
Rosalba Sacca ◽  
Sandra J. Engle ◽  
Wenning Qin ◽  
Jeffrey L. Stock ◽  
John D. McNeish
Keyword(s):  
Drug Discovery ◽  
Mouse Models ◽  
Genetically Engineered ◽  
Genetically Engineered Mouse Models ◽  
Discovery Research ◽  
Drug Discovery Research

WITHDRAWN: Genetically Engineered Mouse Models of Prostate Cancer

2008 ◽  
Author(s):  
Martijn C. Nawijn ◽  
Andreas M. Bergman ◽  
Henk G. van der Poel
Keyword(s):  
Prostate Cancer ◽  
Mouse Models ◽  
Genetically Engineered ◽  
Genetically Engineered Mouse Models

scholarly journals Mouse Models of Prostate Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-22 ◽  
Author(s):  
Kenneth C. Valkenburg ◽  
Bart O. Williams
Keyword(s):  
Prostate Cancer ◽  
Mouse Models ◽  
Human Disease ◽  
High Throughput Screening ◽  
Genetically Engineered ◽  
Screening Methods ◽  
Human Prostate Cancer ◽  
Genetic Changes ◽  
Genetic Pathways ◽  
Genetically Engineered Mouse Models

The development and optimization of high-throughput screening methods has identified a multitude of genetic changes associated with human disease. The use of immunodeficient and genetically engineered mouse models that mimic the human disease has been crucial in validating the importance of these genetic pathways in prostate cancer. These models provide a platform for finding novel therapies to treat human patients afflicted with prostate cancer as well as those who have debilitating bone metastases. In this paper, we focus on the historical development and phenotypic descriptions of mouse models used to study prostate cancer. We also comment on how closely each model recapitulates human prostate cancer.

27A Targeting the PI3K/mTOR pathway in genetically engineered mouse models of advanced prostate cancer

2010 ◽  
Vol 8 (7) ◽  
pp. 18-19
Author(s):  
A. Patnaik ◽  
K. Courtney ◽  
S. Signoretti ◽  
M. Loda ◽  
A. Grant ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mouse Models ◽  
Advanced Prostate Cancer ◽  
Genetically Engineered ◽  
Mtor Pathway ◽  
Genetically Engineered Mouse Models

GENETICALLY ENGINEERED MOUSE MODELS IN PROSTATE CANCER RESEARCH

2011 ◽  
pp. 219-282 ◽  
Author(s):  
Fen Wang ◽  
Wallace L. McKeehan ◽  
Michael M. Shen ◽  
Cory Abate-Shen
Keyword(s):  
Prostate Cancer ◽  
Cancer Research ◽  
Mouse Models ◽  
Genetically Engineered ◽  
Genetically Engineered Mouse Models ◽  
Prostate Cancer Research
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