SEROTONIN TRANSPORTER LENGTH POLYMORPHISM, CHILDHOOD MALTREATMENT, AND CHRONIC DEPRESSION: A SPECIFIC GENE-ENVIRONMENT INTERACTION

2012 ◽  
Vol 30 (1) ◽  
pp. 5-13 ◽  
Author(s):  
George W. Brown ◽  
Maria Ban ◽  
Thomas K. J. Craig ◽  
Tirril O. Harris ◽  
Joe Herbert ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Length Polymorphism ◽  
Childhood Maltreatment ◽  
Chronic Depression ◽  
Specific Gene ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment

scholarly journals Issues concerning feedback about genetic testing and risk of depression

2009 ◽  
Vol 194 (5) ◽  
pp. 404-410 ◽  
Author(s):  
Kay Wilhelm ◽  
Bettina Meiser ◽  
Philip B. Mitchell ◽  
Adam W. Finch ◽  
Jennifer E. Siegel ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Causal Effect ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Individual Genotype ◽  
Gene Environment ◽  
Serotonin Transporter Genotype ◽  
S Allele ◽  
The Impact

BackgroundRecent studies show that adverse life events have a significantly greater impact on depression onset for those with the s/s allele of the genotype for the 5-HT gene-linked promoter region. Research in genes related to risk of depression leads to the question of how this information is received by individuals.AimsTo investigate factors related to the response to receiving one's own serotonin transporter genotype results.MethodPredictors of the impact of receiving individual genotype data were assessed in 128 participants in a study of gene–environment interaction in depression onset.ResultsTwo-thirds decided to learn their individual genotype results (receivers) and prior to disclosure this decision was associated with a perception of greater benefit from receipt of the information (P=0.001). Receivers completing the 2-week (n=76) and 3-month follow-up (n=78) generally reported feeling pleased with the information and having had a more positive experience than distress. However, distress was related to genotype, with those with the s/s allele being most affected.ConclusionsThere was high interest in, and satisfaction with, learning about one's serotonin transporter genotype. Participants appeared to understand that the gene conferred susceptibility to depression rather than a direct causal effect.

Gene–environment interaction on cognition: A twin study of childhood maltreatment and COMT variability

2013 ◽  
Vol 47 (7) ◽  
pp. 989-994 ◽  
Author(s):  
Ximena Goldberg ◽  
Mar Fatjó-Vilas ◽  
Silvia Alemany ◽  
Igor Nenadic ◽  
Cristobal Gastó ◽  
...  
Keyword(s):  
Childhood Maltreatment ◽  
Twin Study ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment

The Effect of Prenatal Valproate Exposure in Serotonin Transporter Knockout Rats On Anxiety and Cognition: A Gene*Environment Interaction Model of Autism Spectrum Disorder

2021 ◽  
Author(s):  
◽  
Caren L. August
Keyword(s):  
Autism Spectrum Disorder ◽  
Cognitive Ability ◽  
Serotonin Transporter ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Starting Point

<p>Autism Spectrum Disorder is a complex neurodevelopmental disorder which is often associated with increased anxiety and deficits in cognitive ability. The present research investigated a potential gene*environment interaction between two factors previously implicated in ASD in a rat model; prenatal exposure to valproate (VPA) and genetic reduction of the serotonin transporter (SERT). Wildtype and heterozygous SERT knockout rats prenatally exposed to VPA or saline on gestational day12.5 (G12.5) were assessed on measures of anxiety: elevated plus-maze and novelty suppressed-feeding and cognitive ability: prepulse inhibition and latent inhibition. A significant main effect was found for VPA exposure in all paradigms, showing increased anxiety-typical behaviour and abnormal cognitive ability. However, no significant effect of genotype or interaction was observed. Results from the present study do not confirm gene*environment interaction between prenatal VPA and heterozygous SERT knockout but this may be due to several factors that are discussed within the thesis. In any case, this study represents a starting point for further studies investigating other combinations of genetic and environmental factors as models of ASD pathogenesis.</p>

scholarly journals Gender-Specific Gene–Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA2

2013 ◽  
Vol 43 (5) ◽  
pp. 402-414 ◽  
Author(s):  
Brea L. Perry ◽  
Bernice A. Pescosolido ◽  
Kathleen Bucholz ◽  
Howard Edenberg ◽  
John Kramer ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Life Events ◽  
Daily Life ◽  
Specific Gene ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
The Impact ◽  
Gender Specific

scholarly journals Nature, nurture and mental disorder: old concepts in the new millennium

2001 ◽  
Vol 178 (S40) ◽  
pp. s91-s101 ◽  
Author(s):  
Brian Cooper
Keyword(s):  
Mental Disorders ◽  
Common Mental Disorders ◽  
Specific Gene ◽  
Environment Interaction ◽  
Adoption Studies ◽  
Gene Environment Interaction ◽  
Diagnostic Categories ◽  
Gene Environment ◽  
Psychiatric Conditions

BackgroundEvidence from twin and adoption studies has highlighted the importance of gene-environment interaction in the aetiology of mental disorders, and advances in molecular genetics have raised hopes of more rapid progress in this field of investigation.AimsTo review epidemiological knowledge concerning genetic and environmental risk factors for a cross-section of psychiatric conditions, and evidence of interaction between the two types.MethodSearches of the literature in genetic and psychiatric epidemiology, including contributions to this supplement.ResultsOverall, firm knowledge on both genetic and environmental causal factors is still fragmentary, although progress has varied among diagnostic categories. Environmental aspects have been dealt with only perfunctorily in most genetic epidemiological research.ConclusionsBetter definition and classification of environmental hazards, and closer inter-disciplinary cooperation, will be necessary in future. Specific gene-environment interaction effects seem likely to prove most important in neuropsychiatric syndromes, and a less specific genetic influence on susceptibility to environmental stress among the common mental disorders.

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