scholarly journals Gene–environment interaction in anorexia nervosa: relevance of non-shared environment and the serotonin transporter gene

2010 ◽  
Vol 16 (6) ◽  
pp. 590-592 ◽  
Author(s):  
A F K Karwautz ◽  
G Wagner ◽  
K Waldherr ◽  
I W Nader ◽  
F Fernandez-Aranda ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Shared Environment ◽  
Environment Interaction ◽  
Transporter Gene ◽  
Gene Environment Interaction ◽  
Gene Environment

High Work Demands and Depression: The Moderating Role of the Serotonin Transporter Gene (5-HTT) and Work Control

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
M. Melchior ◽  
T.E. Moffitt ◽  
R. Poulton ◽  
K. Sugden ◽  
A. Caspi
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Environment Interaction ◽  
Work Demands ◽  
Transporter Gene ◽  
Work Control ◽  
Gene Environment Interaction ◽  
Symptoms Of Depression ◽  
Gene Environment ◽  
High Work

Background:High work demands (i.e. a heavy workload, tight time pressures, conflicting work tasks) put individuals at high risk of depression. Our aim was to test whether the relationship between high work demands and depression is moderated by genetic vulnerability to depression and by work control.Methods:Participants are members of the Dunedin Study, a 1972-73 longitudinal birth cohort assessed most recently in 2004-2005, at age 32 (96% response rate). This analysis included all participants who were employed at age 32. Depression was measured using the Diagnostic Interview Schedule. Work demands and work control were assessed in an interview. Genetic vulnerability to stress was ascertained by the serotonin transporter gene (5-HTT).Results:Among individuals exposed to high work demands, symptoms of depression were significantly higher among those who carried two short alleles of the 5-HTT gene (‘s/s’ group) than among ‘l’ carriers (interaction between 5-HTT gene and work demands: β=4.22, se=1.86, p=0.02). However, this gene-environment interaction was only present among those individuals who had low control over their work (interaction between 5-HTT gene and high work demands: β: 7.21, se: 2.73, p=0.009), not among those who had high work control (interaction between 5-HTT gene and high work demands: β: 1.32, se: 2.53, p=0.60).Conclusion:Pending replication, the serotonin transporter gene appears to moderate the effects of high work demands on symptoms of depression. This gene-environment interaction is attenuated by high work control.

Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Anxiety Reactivity in Daily Life: A Daily Process Approach to Gene-Environment Interaction

2007 ◽  
Vol 69 (8) ◽  
pp. 762-768 ◽  
Author(s):  
Kathleen C. Gunthert ◽  
Tamlin S. Conner ◽  
Stephen Armeli ◽  
Howard Tennen ◽  
Jonathan Covault ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Serotonin Transporter ◽  
Daily Life ◽  
Process Approach ◽  
Serotonin Transporter Gene ◽  
Environment Interaction ◽  
Transporter Gene ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Daily Process Approach

scholarly journals Life events, first depression onset and the serotonin transporter gene

2006 ◽  
Vol 188 (3) ◽  
pp. 210-215 ◽  
Author(s):  
Kay Wilhelm ◽  
Philip B. Mitchell ◽  
Heather Niven ◽  
Adam Finch ◽  
Lucinda Wedgwood ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depression ◽  
Life Events ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Environment Interaction ◽  
Transporter Gene ◽  
Adverse Life Events ◽  
Gene Environment Interaction ◽  
Gene Environment

BackgroundA relationship between the serotonin transporter gene, adverse events and onset of major depression has been reported.AimsTo replicate a gene × environment interaction in a cohort with longitudinal data for life events, experience of depression, parental bonding and neuroticism.MethodAtthe 25-year follow-up, genomic DNA was obtained from 127 cohort members (mean age 48 years) to determine the genotype of the serotonin transporter gene-linked promoter region (5-HTTLPR). Associations were investigated between the 5-HTTLPR genotype, positive and adverse life events and the gene × environment interaction, and also between the 5-HTTLPR genotype and risk factors for depression.ResultsNo relationship was found between 5-HTTLPR genotype and either risk factors for depression or positive life events. Adverse life events had a significantly greater impact on the onset of depression for individuals with the s/s genotype.ConclusionsThe 5-HTTLPR genotype is a significant predictor of onset of major depression following multiple adverse events. This is one of the more robust findings concerning specific biological risk factors for depression.

scholarly journals The interaction between serotonin transporter allelic variation and maternal care modulates sociability on Instagram

2020 ◽  
Author(s):  
Andrea Bonassi ◽  
Ilaria Cataldo ◽  
Giulio Gabrieli ◽  
Moses Tandiono ◽  
Jia Nee Foo ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Social Desirability ◽  
Parental Bonding ◽  
Serotonin Transporter Gene ◽  
Individual Development ◽  
Environment Interaction ◽  
Transporter Gene ◽  
Gene Environment ◽  
The Impact ◽  
Desirability Index

Human social interactions ensure recognition and approval from others, both in offline and online environments. This study applies a model from behavioural genetics on Instagram sociability to explore the impact of individual development on the behaviour on social networks.We hypothesize that sociable attitudes on Instagram resulted from an interaction between serotonin transporter gene alleles and the individual’s social relationship with caregivers. We assess environmental and genetic components of 57 Instagram users. The self-report questionnaire Parental Bonding Instrument is adopted to determine the quality of parental bonding. The number of posts, followed users (“followings”), and followers are collected from Instagram as measures of online social activity. Additionally, the ratio between the number of followers and followings (“Social Desirability Index”) was calculated to estimate the asymmetry of each user’s social network. Finally, buccal mucosa cell samples were acquired, and the polymorphism rs25531 (T/T homozygotes vs C-carriers) within the serotonin transporter gene was examined.In the preliminary analysis, we identified a gender effect on the number of followings. In line with our predictions, we specifically found a gene- environment interaction on the standardized Instagram “Social Desirability Index”: users with the genotype more sensitive to environmental influences (T/T homozygotes) showed a higher Instagram “Social Desirability Index” than non-sensitive ones (C-carriers) when they experienced positive maternal care.This result may contribute to the understanding of online social behaviour from a gene*environment perspective.

Linking the serotonin transporter gene, family environments, hippocampal volume and depression onset: A prospective imaging gene × environment analysis.

2015 ◽  
Vol 124 (4) ◽  
pp. 834-849 ◽  
Author(s):  
Keriann Little ◽  
Craig A. Olsson ◽  
George J. Youssef ◽  
Sarah Whittle ◽  
Julian G. Simmons ◽  
...  
Keyword(s):  
Gene Family ◽  
Serotonin Transporter ◽  
Hippocampal Volume ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Environment Analysis ◽  
Gene Environment

scholarly journals Issues concerning feedback about genetic testing and risk of depression

2009 ◽  
Vol 194 (5) ◽  
pp. 404-410 ◽  
Author(s):  
Kay Wilhelm ◽  
Bettina Meiser ◽  
Philip B. Mitchell ◽  
Adam W. Finch ◽  
Jennifer E. Siegel ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Causal Effect ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Individual Genotype ◽  
Gene Environment ◽  
Serotonin Transporter Genotype ◽  
S Allele ◽  
The Impact

BackgroundRecent studies show that adverse life events have a significantly greater impact on depression onset for those with the s/s allele of the genotype for the 5-HT gene-linked promoter region. Research in genes related to risk of depression leads to the question of how this information is received by individuals.AimsTo investigate factors related to the response to receiving one's own serotonin transporter genotype results.MethodPredictors of the impact of receiving individual genotype data were assessed in 128 participants in a study of gene–environment interaction in depression onset.ResultsTwo-thirds decided to learn their individual genotype results (receivers) and prior to disclosure this decision was associated with a perception of greater benefit from receipt of the information (P=0.001). Receivers completing the 2-week (n=76) and 3-month follow-up (n=78) generally reported feeling pleased with the information and having had a more positive experience than distress. However, distress was related to genotype, with those with the s/s allele being most affected.ConclusionsThere was high interest in, and satisfaction with, learning about one's serotonin transporter genotype. Participants appeared to understand that the gene conferred susceptibility to depression rather than a direct causal effect.

Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa

Life Sciences ◽  
1997 ◽  
Vol 61 (21) ◽  
pp. PL295-PL303 ◽  
Author(s):  
A. Hinney ◽  
N. Barth ◽  
A. Ziegler ◽  
S. Von Prittwitz ◽  
A. Hamann ◽  
...  
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Region
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