Rosai‐Dorfman disease of the pancreas: Cytologic analysis of three cases presenting as pancreatic masses

Abstract Background and study aims The optimal technique for sampling pancreatic lesions with a 22 G Procore needle (pc) is unknown. The aims of this study were to evaluate the 22 Gpc using standard suction technique (SST) and capillary suction technique (CST) and compare diagnostic adequacy of 22 Gpc with the standard 25 G needle. Patients and methods Sixty consecutive patients referred for EUS-FNA of a solid pancreatic mass were prospectively evaluated. All patients underwent 2 passes with a standard 25 G needle for cytologic analysis. The first group of 30 patients underwent a single pass with the 22 Gpc needle using SST for cytology and histology. The second group underwent a single pass with the 22 Gpc needle using CST. The sequence of passes was randomized. The diagnostic adequacy of each pass was graded by 2 cytopathologists blinded to technique and needle type for comparison. Results For a cytologic diagnosis with 22 Gpc, an adequate sample was obtained in 82.8 % SST vs. 80.0 % CST (P = 0.79). For a histologic diagnosis with 22 Gpc, an adequate sample was obtained in 70.4 % SST vs. 69.0 % CST (P = 0.91). A single pass with 22 Gpc provided comparable results to a single pass with the 25 G needle for a cytologic diagnosis; both were superior to a single 22 Gpc pass for a histologic diagnosis. Two passes with the 25 G needle provided a diagnostic specimen in 95.0 % vs 81.4 % with one pass using 22 Gpc (P = 0.01). Conclusions No significant difference in diagnostic adequacy was observed between techniques for the 22 Gpc. Two passes with a 25 G needle performed better than 1 pass with 22 Gpc. (NCT01598194)Meeting presentations: Digestive Disease Week 2015

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EUS-guided FNA of solid pancreatic masses: high yield of 2 passes with combined histologic-cytologic analysis

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2008.10.008 ◽

2009 ◽

Vol 70 (1) ◽

pp. 60-69 ◽

Cited By ~ 74

Author(s):

Kathleen Möller ◽

Ioannis S. Papanikolaou ◽

Thomas Toermer ◽

Eumorphia M. Delicha ◽

Mario Sarbia ◽

...

Keyword(s):

High Yield ◽

Pancreatic Masses ◽

Cytologic Analysis

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ROLE OF SEMIQUANTITATIVE ELASTOGRAPHY BY STRAIN RATIO IN PREDICTING MALIGNANCY OF PANCREATIC MASSES

10.1055/s-0038-1637374 ◽

2018 ◽

Author(s):

D Vasile Balaban ◽

C Marina ◽

A Zoican ◽

G Robu ◽

I Enache ◽

...

Keyword(s):

Strain Ratio ◽

Pancreatic Masses ◽

Semiquantitative Elastography

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Rosai-Dorfman Disease Presenting as a Lateral Skull Base Tumor with Intracranial Spread: A Case Report

10.1055/s-0039-1679792 ◽

2019 ◽

Author(s):

Gauri Mankekar ◽

George Jeha ◽

Ma Arriaga ◽

Kelly Scrantz ◽

J. Olson

Keyword(s):

Case Report ◽

Skull Base ◽

Skull Base Tumor ◽

Lateral Skull Base ◽

Rosai Dorfman Disease

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Clinical Manifestations and Radiological Characteristics on Rosai-Dorfman Disease: A Retrospective Observational Study

Medical & Clinical Research ◽

10.33140/mcr.05.05.005 ◽

2020 ◽

Vol 5 (5) ◽

Keyword(s):

Blood Vessels ◽

Abdominal Cavity ◽

Clinical Manifestations ◽

Ct Images ◽

High Signal ◽

Radiological Features ◽

Imaging Characteristics ◽

Rosai Dorfman Disease ◽

Heterogeneous Enhancement ◽

The Masses

Background and Objective: Rosai-Dorfman disease (RDD) are usually misdiagnosed because of rarity and nonspecific clinical and radiological features. The aim of our study is to explore the clinical and imaging characteristics of RDD to improve diagnostic accuracy. Methods: Clinical and imaging data in 10 patients with RDD were retrospectively analyzed. 7 patients were underwent CT scanning and 3 patients were underwent MR examination. Results: 8 (8/10) patients presented with painless enlarged lymph nodes (LNs) or mass. 3 cases were involved with LNs, 5 cases were involved with extra-nodal tissues, and the remaining 2 cases were involved with LNs and extra-nodal tissue simultaneously. In enhanced CT images, enlarged LNs displayed mild or moderate enhancement, and 2 cases showed heterogeneous ring-enhancement. MR features of 3 patients with extra-nodal RDD, 2 cases showed a mass located in the subcutaneous and anterior abdominal wall respectively, and 1 case showed an intracranial mass. Besides, all lesions showed high signal foci on DWI images, and were characterized by marked heterogeneous enhancement with blurred edge. The dural/fascia tail sign and dilated blood vessels could be seen around all the lesions on enhanced MRI. Radiological features of 2 cases with LN and extranodal tissue involved, one case presented with the swelling and thickening of pharyngeal lymphoid ring and nasopharynx, meanwhile with enlarged LNs in bilateral submandibular area, neck and abdominal cavity, and also companied with osteolytic lesion in right proximal humerus. All these LNs displayed mild and moderate enhancement on CT images. Another case showed enlarged LNs in bilateral neck accompanied with soft tissue mass in the sinuses. Conclusions: RDD occurred commonly in young and middle-aged men and presented with painless enlarged LNs or mass.RDD had a huge diversity of imaging findings, which varied with different location. The radiological features, such as small patches of high signal foci in the masses on DWI images, heterogeneous enhancement and blood vessels around the masses, are helpful in diagnosis of extranodal RDD.

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