Utility of an immunocytochemical analysis for pan‐Trk in the cytodiagnosis of secretory carcinoma of the salivary gland

2021 ◽  
Author(s):  
Hiroko Ito ◽  
Mitsuaki Ishida ◽  
Yusuke Ebisu ◽  
Kimiaki Okano ◽  
Kaori Sandoh ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Secretory Carcinoma ◽  
Immunocytochemical Analysis

Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers

2015 ◽  
Vol 46 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Makoto Urano ◽  
Toshitaka Nagao ◽  
Satoru Miyabe ◽  
Kenichiro Ishibashi ◽  
Kayoko Higuchi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Surrogate Markers ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma

scholarly journals Mammary analogue secretory carcinoma: a rare salivary gland tumor

2020 ◽  
Vol 6 (5) ◽  
pp. 998
Author(s):  
Shashikant Anil Pol ◽  
Surinder K. Singhal ◽  
Nitin Gupta ◽  
Himanshu Bayad
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Good Prognosis ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Grade Malignancy ◽  
Enhanced Computed Tomography ◽  
Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

Expression of upstream and downstream targets of mTOR pathway in seven cases of secretory carcinoma of salivary gland origin

2020 ◽  
Author(s):  
Marcos Custódio ◽  
Bruno Tavares Sedassari ◽  
Albina Altemani ◽  
Maria Fernanda Setúbal Destro Rodrigues ◽  
Fábio Daumas Nunes ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Mtor Pathway ◽  
Secretory Carcinoma ◽  
Downstream Targets

scholarly journals Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland

2013 ◽  
Vol 47 (1) ◽  
pp. 36 ◽  
Author(s):  
Min Jung Jung ◽  
Joon Seon Song ◽  
Sang Yoon Kim ◽  
Soon Yuhl Nam ◽  
Jong-Lyel Roh ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma

scholarly journals Characterization of novel genetic alterations in salivary gland secretory carcinoma

2019 ◽  
Vol 33 (4) ◽  
pp. 541-550 ◽  
Author(s):  
Kiyong Na ◽  
Juan C. Hernandez-Prera ◽  
Jae-Yol Lim ◽  
Ha Young Woo ◽  
Sun Och Yoon
Keyword(s):  
Salivary Gland ◽  
Fusion Gene ◽  
Salivary Gland Tumor ◽  
Treatment Strategies ◽  
Chromosomal Translocation ◽  
Genetic Alterations ◽  
Secretory Carcinoma ◽  
Clinicopathologic Characteristics ◽  
Pathogenic Variants ◽  
Tumorigenesis And Progression

AbstractSecretory carcinoma is a salivary gland tumor with a characteristic chromosomal translocation that results in an ETV6-NTRK3 fusion gene. Secretory carcinoma shows relatively frequent rates of lymph-node metastasis and tumor recurrence and has a characteristic histology. Except for the ETV6 translocation, genomic alterations in secretory carcinoma have not been reported. In the present study, we characterized the novel recurrent genetic mutations of secretory carcinoma. On the basis of histology, immunohistochemistry, and ETV6 gene break-apart fluorescence in situ hybridization assays, 22 tumors were classified as secretory carcinomas (19 ETV6 translocation-positive and 3 ETV6 translocation-negative secretory carcinomas) and their clinicopathologic characteristics were reviewed. Targeted deep sequencing analyses were performed on 20 secretory carcinomas (17 ETV6 translocation-positive and 3 ETV6 translocation-negative secretory carcinomas) to investigate their genetic alterations. The A16V (C→T) mutation in PRSS1, which encodes a cationic trypsinogen and has a mutation associated with hereditary pancreatitis and pancreatic adenocarcinoma, was observed in 40% (8/20) (7/17 of ETV6 translocation-positive and 1/3 of ETV6 translocation-negative secretory carcinomas). Pathogenic variants of MLH1, MUTYH, and STK11 were also identified. Variants of uncertain significance included mutations in KMT5A. These novel characteristic genetic alterations may advance current understandings of secretory carcinoma tumorigenesis and progression, leading to improved diagnoses and treatment strategies.

scholarly journals Concurrent Identification of Novel EGFR–SEPT14 Fusion and ETV6–RET Fusion in Secretory Carcinoma of the Salivary Gland

2019 ◽  
Vol 14 (3) ◽  
pp. 817-821 ◽  
Author(s):  
Margaret Black ◽  
Cheng Z. Liu ◽  
Maristela Onozato ◽  
Anthony John Iafrate ◽  
Farbod Darvishian ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Secretory Carcinoma

Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland

2020 ◽  
Author(s):  
Yuichiro Hamamoto ◽  
Hiroshi Harada ◽  
Masaharu Kohara ◽  
Keiichiro Honma ◽  
Shin-ichi Nakatsuka ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Secretory Carcinoma ◽  
Acinic Cell

scholarly journals Mammary analogue secretory carcinoma: Update on a new diagnosis of salivary gland malignancy

2013 ◽  
Vol 124 (1) ◽  
pp. 188-195 ◽  
Author(s):  
Roshan Sethi ◽  
Elliott Kozin ◽  
Aaron Remenschneider ◽  
Josh Meier ◽  
Paul VanderLaan ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Salivary Gland Malignancy ◽  
New Diagnosis
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