A comparative immunohistochemistry study of diagnostic tools in salivary gland tumors: usefulness of mammaglobin, gross cystic disease fluid protein 15, and p63 cytoplasmic staining for the diagnosis of mammary analog secretory carcinoma?

BACKGROUND: Secretory carcinoma (SC) of the salivary gland, also known as mammary analog secretory carcinoma, is a rare tumor in the parotid gland. This kind of tumor is characterized by generally indolent clinical behavior and expression of a break in the ETV6 gene. CASE REPORT: We present a unique case of secretory carcinoma and show its favorable prognoses. CONCLUSION: Secretory carcinoma of the salivary gland is a low-grade carcinoma with a favorable prognosis. It has low regional lymph node and distant metastasis potential. Due to the possibility of misdiagnosis, immunohistochemical studies and FISH are suggested. The most effective treatment is complete surgical excision with negative surgical margins.

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Mammary analog secretory carcinoma of salivary gland: Cytologic diagnosis and differential diagnosis of an unreported entity

Diagnostic Cytopathology ◽

10.1002/dc.21766 ◽

2012 ◽

Vol 41 (3) ◽

pp. 239-241 ◽

Cited By ~ 29

Author(s):

Latha Pisharodi

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Secretory Carcinoma ◽

Cytologic Diagnosis ◽

Mammary Analog Secretory Carcinoma

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Mammary analog secretory carcinoma of salivary gland in a 5 year old: Case report

International Journal of Pediatric Otorhinolaryngology Extra ◽

10.1016/j.pedex.2014.09.003 ◽

2014 ◽

Vol 9 (4) ◽

pp. 163-165 ◽

Cited By ~ 7

Author(s):

Matthew Keisling ◽

Michael Bianchi ◽

Judy Mae Pascasio

Keyword(s):

Salivary Gland ◽

Case Report ◽

Secretory Carcinoma ◽

Mammary Analog Secretory Carcinoma

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The cytopathologic features of mammary analog secretory carcinoma and its mimics

CytoJournal ◽

10.4103/1742-6413.139726 ◽

2014 ◽

Vol 11 ◽

pp. 24 ◽

Cited By ~ 20

Author(s):

T. Danielle Samulski ◽

Virginia A. LiVolsi ◽

Zubair Baloch

Keyword(s):

Salivary Gland ◽

Mucoepidermoid Carcinoma ◽

Needle Aspiration ◽

Definite Diagnosis ◽

Secretory Carcinoma ◽

Warthin Tumor ◽

Fine Needle ◽

Monomorphic Population ◽

Mammary Analog Secretory Carcinoma ◽

Foamy Cytoplasm

Mammary Analogue Secretory Carcinoma (MASC) is a newly recognized neoplasm of the salivary gland, first described in 2010. This tumor harbors a unique translocation, t(12;15)(p13;q25) that results in the fusion of ETV6 with NTRK3 which produces a transformative chimeric tyrosine kinase. To date, few cases of MASC sampled by fine needle aspiration have been reported. Cytologically, MASC can be confused with other oncocytic salivary gland tumors, including Warthin-tumor, acinic cell carcinoma (AciCC) and mucoepidermoid carcinoma. It is characterized by a monomorphic population of lesional cells with round nuclei, prominent nucleoli and abundant, eosinophilic foamy cytoplasm; forming papillary groups with transgressing vessels. Though, based on cytomorphology alone, the definite diagnosis can be challenging, in conjunction with available clinical clues (i.e. male patient, extra-parotid site) MASC should be included in the differential diagnosis of FNA specimens diagnosed as oncocytic salivary gland neoplasms or suspicious for AciCC. Here we present a case of MASC with FNA sampling at our institution.

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Human Kallikrein 13 Expression in Salivary Gland Tumors

The International Journal of Biological Markers ◽

10.1177/172460080602100206 ◽

2006 ◽

Vol 21 (2) ◽

pp. 106-110 ◽

Cited By ~ 18

Author(s):

M.R. Darling ◽

L. Jackson-Boeters ◽

T.D. Daley ◽

E.P. Diamandis

Keyword(s):

Salivary Gland ◽

Salivary Gland Tumors ◽

Low Grade ◽

Cytoplasmic Staining ◽

Normal Tissues ◽

Ductal Cells ◽

Not Otherwise Specified ◽

Salivary Gland Tissue ◽

Gland Tissue ◽

Normal Salivary Gland

The human kallikrein 13 protein (hK13) is expressed in many normal tissues. Petraki et al have previously described presence of hK13 in salivary gland tissue, localized to duct epithelia and some acinar cells. The aim of this study was to determine whether hK13 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), polymorphous low grade adenocarcinomas (PLGA), acinic cell carcinomas (ACI), mucoepidermoid carcinomas (MEC) and adenocarcinomas not otherwise specified (ANOS) of both minor and major salivary glands were examined. The results of this study indicate that most salivary gland tumors show high levels of expression of hK13. Overall, staining in PA was significantly less than that seen in normal salivary gland tissue. PLGA, ACC and ANOS each stained significantly more than normal salivary gland tissue while MEC and ACI did not. Ductal cells and cells lining duct-like structures showed a higher intensity of staining than non-ductal cells in most tumors. Tumors which exhibited only non-ductal cells also exhibited cytoplasmic staining. In conclusion, we demonstrate the high expression of hK13 in several common salivary gland tumors.

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