Novel low-molecular-weight superoxide dismutase mimic deferoxamine-manganese improves survival following hemorrhagic and endotoxic shock

1992 ◽  
Vol 25 (2) ◽  
pp. 139-148 ◽  
Author(s):  
Lawrence De Garavilla ◽  
Timothy Chermak ◽  
Heather L. Valentine ◽  
Robert C. Hanson
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Endotoxic Shock ◽  
Low Molecular Weight ◽  
Superoxide Dismutase Mimic

Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens

1992 ◽  
Vol 19 (1) ◽  
pp. 21-26 ◽  
Author(s):  
William G. Degraff ◽  
Murali C. Krishna ◽  
Angelo Russo ◽  
James B. Mitchell
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Low Molecular Weight ◽  
Superoxide Dismutase Mimic

scholarly journals A novel metal-free low molecular weight superoxide dismutase mimic.

1988 ◽  
Vol 263 (34) ◽  
pp. 17921-17924
Author(s):  
A Samuni ◽  
C M Krishna ◽  
P Riesz ◽  
E Finkelstein ◽  
A Russo
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Low Molecular Weight ◽  
Metal Free ◽  
Superoxide Dismutase Mimic

Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis

1995 ◽  
Vol 18 (2) ◽  
pp. 153-160
Author(s):  
Zbigniew Śledziński ◽  
Michal Woźniak ◽  
J⊹drzej Antosiewicz ◽  
Emanuele Lezoche ◽  
Massimo Familiari ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Free Radical ◽  
Protective Effect ◽  
Experimental Pancreatitis ◽  
Low Molecular Weight ◽  
Superoxide Dismutase Mimic

Cereals frost resistance correlates with an integral indicators of content of low-molecular-weight protective compounds and activity of antioxidant enzymes

2020 ◽  
Vol 2020 (3) ◽  
pp. 71-86
Author(s):  
O. I. Horielova ◽  
◽  
N. I. Ryabchun ◽  
M. A. Shkliarevskyi ◽  
A. M. Reznik ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Antioxidant System ◽  
Frost Resistance ◽  
Low Molecular Weight ◽  
Guaiacol Peroxidase ◽  
Wheat Seedlings ◽  
Enzymatic Antioxidant ◽  
Adult Plants

Along with specific adaptive reactions, universal defense reactions, in particular activation of antioxidant system, are of great importance for plant survival under cold conditions. We have studied a relationship among the content of low-molecular-weight protective compounds with antioxidant properties (proline, soluble carbohydrates, flavonoids), the activity of antioxidant enzymes (superoxide dismutase, catalase, and guaiacol peroxidase) in seedlings of winter wheat, rye and triticale, and frost resistance of etiolated seedlings and adult plants at tillering stage. It was found that there was a fairly close correlation between the frost resistance of seedlings and adult cereal plants (r = 0,78). It was shown that a pronounced relationship between individual indicators of antioxidant system functioning in unhardened seedlings and their frost resistance was not found. After 6-day hardening of seedlings at 2-4°C, there was a high correlation between the total indicator of the enzymatic antioxidant system (the sum of normalized indicators of superoxide dismutase, peroxidase, and catalase activity) and their frost resistance (r = 0,86), but the correlation coefficient of this index with frost resistance of plants in tillering phase was significantly lower (r = 0,47). At the same time, a high correlation was found between the content of low-molecular-weight protectors in hardened seedlings and frost resistance of tillering adult plants (r = 0.89). The closest correlation was observed between the integral normalized indicator, comprising the sum of normalized values of antioxidant enzymes activity and the content of low-molecular-weight protectors in hardened seedlings, and frost resistance of seedlings (r = 0,94) and plants in tillering phase (r = 0,89). A presence of specific features in the functioning of antioxidant system during cold adaptation of cereal seedlings was established. Rye is characterized by a high content of low-molecular-weight protective compounds; at the same time, increased activity of antioxidant enzymes - superoxide dismutase and catalase - was noted in wheat seedlings. In triticale, depending on the genotype, the values of both enzymatic antioxidant activity and the content of low-molecular-weight protectors varied.

scholarly journals Comparative Evaluation of Prooxidant/Antioxidant Balance in Seed Progeny of Plantago major L. from Radioactively and Chemically Contaminated Areas

2001 ◽  
Vol 14 (3) ◽  
pp. 306-317
Author(s):  
Nadezhda S. Shimalina ◽  
◽  
Natal'ya A. Orekhova ◽  
Vera N. Pozolotina
Keyword(s):  
Heavy Metals ◽  
Reactive Oxygen Species ◽  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Comparative Evaluation ◽  
Low Molecular Weight ◽  
Oxygen Species ◽  
Plantago Major ◽  
Seed Progeny ◽  
Reference Samples

There are many studies addressing plant responses to radioactive and chemical contamination of soils, but few works have been devoted to comparison of biological effects in the areas affected by these human-induced factors. Ionizing radiation and heavy metals have different mechanisms of interaction with biota. Both factors, however, are capable of increasing the generation of reactive oxygen species, which cause enzyme malfunction and cell structure damage. The efficiency of antioxidant systems plays an important role in plant resistance to these impacts. The present study offers a comparative evaluation of prooxidant/antioxidant balance in seed progeny of Plantago major L. growing in the East Ural Radioactive Trace (EURT), in the zone affected by operation of the Karabash Copper Smelter (KCS), and in the reference sites. Lipid peroxidation was assessed by determining malondialdehyde. Evaluation of the antioxidant system was based on the activities of superoxide dismutase, catalase, and total peroxidase, and on the content of low-molecular-weight antioxidants. The study showed that the prooxidant and antioxidant statuses of seed progeny of P. major from the contaminated sites were different from the reference samples and from each other. The pooled EURT sample exhibited a prooxidant shift relative to the reference samples, i. e. not only malondialdehyde but also activities of superoxide dismutase and catalase and the content of low-molecular-weight antioxidants were higher than in the reference samples. Malondialdehyde content in seedlings from the KCS zone did not differ from the reference values; superoxide dismutase and catalase activities were decreased whereas peroxidase activity was higher compared to the activities of these enzymes in the reference samples. Thus, the differences in the plant adaptive responses to ionizing radiation and heavy metals are caused by the dissimilarities in the induction of reactive oxygen species

Characterization and stability investigation of Cu,Zn-superoxide dismutase covalently modified by low molecular weight heparin

2006 ◽  
Vol 71 (S1) ◽  
pp. S96-S100 ◽  
Author(s):  
H. W. Zhang ◽  
F. S. Wang ◽  
W. Shao ◽  
X. L. Zheng ◽  
J. Z. Qi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Stability Investigation

scholarly journals Mutant Copper-Zinc Superoxide Dismutase Binds to and Destabilizes Human Low Molecular Weight Neurofilament mRNA

2004 ◽  
Vol 280 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Wei-Wen Ge ◽  
Weiyan Wen ◽  
Wendy Strong ◽  
Cheryl Leystra-Lantz ◽  
Michael J. Strong
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Low Molecular Weight ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Copper Zinc

Characteristics of low molecular weight substances regulating plasma superoxide dismutase activity

1994 ◽  
Vol 17 (4) ◽  
pp. 351-353 ◽  
Author(s):  
Elene E. Dubinina ◽  
Irina V. Shugaley ◽  
Alexander T. Melenevsky ◽  
Igor V. Tselinskii
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Superoxide Dismutase Activity ◽  
Low Molecular Weight
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