superoxide dismutase mimic
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2021 ◽  
Vol 3 ◽  
pp. 100016
Author(s):  
Sarah L. Schlichte ◽  
Elizabeth J. Pekas ◽  
Taylor J. Bruett ◽  
Elizabeth A. Kosmacek ◽  
Bryan T. Hackfort ◽  
...  


Redox Biology ◽  
2020 ◽  
Vol 36 ◽  
pp. 101610
Author(s):  
Sarah L. Schlichte ◽  
Svetlana Romanova ◽  
Kenichi Katsurada ◽  
Elizabeth A. Kosmacek ◽  
Tatiana K. Bronich ◽  
...  


2020 ◽  
Vol 56 (57) ◽  
pp. 7885-7888
Author(s):  
Emilie Mathieu ◽  
Anne-Sophie Bernard ◽  
Elodie Quévrain ◽  
Martha Zoumpoulaki ◽  
Sébastien Iriart ◽  
...  

The study of Mn-based superoxide dismutase mimic conjugated with a multimodal Re-probe in a cellular model of oxidative stress revealed that its bioactivity is associated with its accumulation at the mitochondria.



2020 ◽  
Vol 49 (7) ◽  
pp. 2323-2330
Author(s):  
Emilie Mathieu ◽  
Anne-Sophie Bernard ◽  
H. Y. Vincent Ching ◽  
Andrea Somogyi ◽  
Kadda Medjoubi ◽  
...  

A superoxide dismutase mimic was functionalized with three peptides: -R9, -RRWWRRWRR or -Fx-r-Fx-K (MPP). They were studied in intestinal epithelial cells in an inorganic cellular chemistry approach: quantification, distribution and bio-activity.







2017 ◽  
Vol 280 ◽  
pp. S112
Author(s):  
João G. Costa ◽  
Nuno Saraiva ◽  
Patrícia S. Guerreiro ◽  
Matilde Castro ◽  
Ines Batinic-Haberle ◽  
...  


Redox Biology ◽  
2017 ◽  
Vol 12 ◽  
pp. 864-871 ◽  
Author(s):  
David Leu ◽  
Ivan Spasojevic ◽  
Huy Nguyen ◽  
Brian Deng ◽  
Artak Tovmasyan ◽  
...  


Molekul ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 61 ◽  
Author(s):  
Yusi Deawati ◽  
Djulia Onggo ◽  
Irma Mulyani ◽  
Iwan Hastiawan ◽  
Dikdik Kurnia

The complex compound of [Mn(salen)OAc] can serve as mSOD and its activity has been determined non-enzymatically in vitro through riboflavin photoreduction. The complex was synthesized from Mn(OAc)2.4H2O and H2salen. Based on the elemental analysis, the C=56.69%; H=4.21%; and N=7.52% content are corresponding to the chemical formula of MnC18H17N2O4. The functional groups and ionic species in the complex have been analyzed by infrared spectroscopy and ESI-MS. SOD activity was determined by mixing complex at various concentrations with riboflavin and nitroblue tetrazolium (NBT), then the mixture was lighted with 20 Watt tungsten lamp for 15 minutes in a closed box. Then the reduced NBT absorptions were measured at λ 560 nm. The difference of absorbance between standard and sample solutions (without and with riboflavin, respectively) was multiplied by 100% to obtain %inhibition of each various sample concentration against NBT. SOD activity was obtained from IC50 data defined as a 50% inhibition of the plot curve of % inhibition to the concentration of the complex. The result obtained for this compound is IC50 = 2.7 ± 0.05 µM as well as enzymatic method. Therefore, this method can be used to determine the SOD activity by giving more stability and accuracy of IC50 value.



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