scholarly journals Impact of mothers’ experience and early‐life stress on aggression and cognition in adult male mice

2019 ◽  
Vol 62 (1) ◽  
pp. 36-49 ◽  
Author(s):  
Vasiliy V. Reshetnikov ◽  
Yulia A. Ryabushkina ◽  
Natalia P. Bondar
Keyword(s):  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice

scholarly journals Impact of mothers’ past experience and early-life stress on aggression and cognition in adult male mice

2018 ◽  
Author(s):  
V. Reshetnikov ◽  
Yu. Ryabushkina ◽  
N. Bondar
Keyword(s):  
Locomotor Activity ◽  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Life Experience ◽  
Early Life Stress ◽  
Male Mice ◽  
Female Mice ◽  
Stressful Experience

AbstractEarly life is an important period for brain development and behavioral programming. Both reduced maternal care and stress in early life are risk factors for various psychiatric disorders. Here, we hypothesized that females’ stressful experience in their early life can lead to a disruption of mother-offspring interactions toward their own progeny. The objective of this study is to assess the effects of mothers’ past stressful experience, early-life stress alone or both on behavior in adult male mice. In this study, female mice were allowed to raise their pups either without exposure to stress (normal rearing condition, NC) or with exposure to maternal separation (3h/day, maternal separation, MS) on postnatal days 2–14. Adult F1 female mice who had experienced MS (stressed mothers, SM) or had been reared normally (undisturbed mothers, UM) were used for generating F2 offspring to be or not to be further exposed to early-life stress. We assessed anxiety-like behavior, exploratory activity, locomotor activity, aggression and cognition in four groups of adult F2 males (UM+NC, UM+MS, SM+NC, SM+MS). We found that SM+MS males become more aggressive if agonistic contact is long enough, suggesting a change in their social coping strategy. Moreover, these aggressive males tended to improve longterm spatial memory. Aggressive SM+NC males, in contrast, showed learning impairments. We did not find any significant differences in anxiety-like behavior or exploratory and locomotor activity. Overall, our findings suggest that mothers’ early-life experience may have important implications for the adult behavior of their offspring.

scholarly journals Early‐life Stress Induces Dysregulated Heme Homeostasis and Pro‐inflammatory Phenotype in Adult Male Mice

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Dao Ho ◽  
Yasminye Pettway ◽  
Mariah Burch ◽  
Jennifer Pollock
Keyword(s):  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice ◽  
Inflammatory Phenotype

scholarly journals Effects of early-life stress on peripheral and central mitochondria in male mice across ages

2021 ◽  
pp. 105346
Author(s):  
S.R. Ruigrok ◽  
K. Yim ◽  
T.L. Emmerzaal ◽  
B. Geenen ◽  
N. Stöberl ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice

scholarly journals Sexual dimorphic role of the glucocorticoid receptor in chronic muscle pain produced by early-life stress

2021 ◽  
Vol 17 ◽  
pp. 174480692110113
Author(s):  
Paul G Green ◽  
Pedro Alvarez ◽  
Jon D Levine
Keyword(s):  
Glucocorticoid Receptor ◽  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Glucocorticoid Receptors ◽  
Early Life Stress ◽  
Nociceptive Threshold ◽  
Male And Female ◽  
Mechanical Nociceptive Threshold

Fibromyalgia and other chronic musculoskeletal pain syndromes are associated with stressful early life events, which can produce a persistent dysregulation in the hypothalamic-pituitary adrenal (HPA) stress axis function, associated with elevated plasm levels of corticosterone in adults. To determine the contribution of the HPA axis to persistent muscle hyperalgesia in adult rats that had experienced neonatal limited bedding (NLB), a form of early-life stress, we evaluated the role of glucocorticoid receptors on muscle nociceptors in adult NLB rats. In adult male and female NLB rats, mechanical nociceptive threshold in skeletal muscle was significantly lower than in adult control (neonatal standard bedding) rats. Furthermore, adult males and females that received exogenous corticosterone (via dams’ milk) during postnatal days 2–9, displayed a similar lowered mechanical nociceptive threshold. To test the hypothesis that persistent glucocorticoid receptor signaling in the adult contributes to muscle hyperalgesia in NLB rats, nociceptor expression of glucocorticoid receptor (GR) was attenuated by spinal intrathecal administration of an oligodeoxynucleotide (ODN) antisense to GR mRNA. In adult NLB rats, GR antisense markedly attenuated muscle hyperalgesia in males, but not in females. These findings indicate that increased corticosterone levels during a critical developmental period (postnatal days 2–9) produced by NLB stress induces chronic mechanical hyperalgesia in male and female rats that persists in adulthood, and that this chronic muscle hyperalgesia is mediated, at least in part, by persistent stimulation of glucocorticoid receptors on sensory neurons, in the adult male, but not female rat.

Enhancement of nerve-injury-induced thermal and mechanical hypersensitivity in adult male and female mice following early life stress

Life Sciences ◽  
2015 ◽  
Vol 121 ◽  
pp. 28-34 ◽  
Author(s):  
Takashi Nishinaka ◽  
Kazuo Nakamoto ◽  
Shogo Tokuyama
Keyword(s):  
Nerve Injury ◽  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male And Female ◽  
Mechanical Hypersensitivity ◽  
Female Mice

scholarly journals Early life stress impairs contextual threat expression in female, but not male, mice.

2018 ◽  
Vol 132 (4) ◽  
pp. 247-257 ◽  
Author(s):  
Gabriela Manzano-Nieves ◽  
Mizan Gaillard ◽  
Meghan Gallo ◽  
Kevin G. Bath
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice

scholarly journals Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice

Pain ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Isabella M. Fuentes ◽  
Brittni M. Jones ◽  
Aaron D. Brake ◽  
Angela N. Pierce ◽  
Olivia C. Eller ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Chronic Pelvic Pain ◽  
Wheel Running ◽  
Chronic Pelvic Pain Syndrome ◽  
Early Life Stress ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Male Mice ◽  
Voluntary Wheel

scholarly journals Early life stress results in an exaggerated pressor response to acute air jet stress in adult male, but not female rats

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
David M Pollock ◽  
Gerard D'Angelo ◽  
Jeffrey A Bobo ◽  
Jennifer S Pollock
Keyword(s):  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Pressor Response ◽  
Early Life Stress ◽  
Female Rats ◽  
Air Jet

Early life stress impairs social recognition due to a blunted response of vasopressin release within the septum of adult male rats

2011 ◽  
Vol 36 (6) ◽  
pp. 843-853 ◽  
Author(s):  
Michael Lukas ◽  
Remco Bredewold ◽  
Rainer Landgraf ◽  
Inga D. Neumann ◽  
Alexa H. Veenema
Keyword(s):  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Social Recognition ◽  
Male Rats ◽  
Vasopressin Release
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