scholarly journals Sexual dimorphic role of the glucocorticoid receptor in chronic muscle pain produced by early-life stress

2021 ◽  
Vol 17 ◽  
pp. 174480692110113
Author(s):  
Paul G Green ◽  
Pedro Alvarez ◽  
Jon D Levine
Keyword(s):  
Glucocorticoid Receptor ◽  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Glucocorticoid Receptors ◽  
Early Life Stress ◽  
Nociceptive Threshold ◽  
Male And Female ◽  
Mechanical Nociceptive Threshold

Fibromyalgia and other chronic musculoskeletal pain syndromes are associated with stressful early life events, which can produce a persistent dysregulation in the hypothalamic-pituitary adrenal (HPA) stress axis function, associated with elevated plasm levels of corticosterone in adults. To determine the contribution of the HPA axis to persistent muscle hyperalgesia in adult rats that had experienced neonatal limited bedding (NLB), a form of early-life stress, we evaluated the role of glucocorticoid receptors on muscle nociceptors in adult NLB rats. In adult male and female NLB rats, mechanical nociceptive threshold in skeletal muscle was significantly lower than in adult control (neonatal standard bedding) rats. Furthermore, adult males and females that received exogenous corticosterone (via dams’ milk) during postnatal days 2–9, displayed a similar lowered mechanical nociceptive threshold. To test the hypothesis that persistent glucocorticoid receptor signaling in the adult contributes to muscle hyperalgesia in NLB rats, nociceptor expression of glucocorticoid receptor (GR) was attenuated by spinal intrathecal administration of an oligodeoxynucleotide (ODN) antisense to GR mRNA. In adult NLB rats, GR antisense markedly attenuated muscle hyperalgesia in males, but not in females. These findings indicate that increased corticosterone levels during a critical developmental period (postnatal days 2–9) produced by NLB stress induces chronic mechanical hyperalgesia in male and female rats that persists in adulthood, and that this chronic muscle hyperalgesia is mediated, at least in part, by persistent stimulation of glucocorticoid receptors on sensory neurons, in the adult male, but not female rat.

Adolescent oxytocin administration reduces depression-like behaviour induced by early life stress in adult male and female rats

2021 ◽  
Vol 110 ◽  
pp. 110279
Author(s):  
Jade L. Thornton ◽  
Nicholas A. Everett ◽  
Paige Webb ◽  
Anita J. Turner ◽  
Jennifer L. Cornish ◽  
...  
Keyword(s):  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

Early life stress impairs fear conditioning in adult male and female rats

2006 ◽  
Vol 1087 (1) ◽  
pp. 142-150 ◽  
Author(s):  
Therese A. Kosten ◽  
Hongjoo J. Lee ◽  
Jeansok J. Kim
Keyword(s):  
Fear Conditioning ◽  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

The Role of Early Life Stress in HPA Axis and Anxiety

2020 ◽  
pp. 141-153 ◽  
Author(s):  
Mario F. Juruena ◽  
Filip Eror ◽  
Anthony J. Cleare ◽  
Allan H. Young
Keyword(s):  
Hpa Axis ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

scholarly journals Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Catherine Jensen Peña ◽  
Milo Smith ◽  
Aarthi Ramakrishnan ◽  
Hannah M. Cates ◽  
Rosemary C. Bagot ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Cortical Plasticity ◽  
Early Life Stress ◽  
Stress Sensitivity ◽  
Sensitive Period ◽  
Male And Female ◽  
Reward Circuitry ◽  
Female Mice ◽  
Increase Risk

Abstract Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice, consistent with our earlier findings in male mice. We used RNA-sequencing in the ventral tegmental area, nucleus accumbens, and prefrontal cortex of male and female mice to show that adult stress is distinctly represented in the brain’s transcriptome depending on ELS history. We identify: 1) biological pathways disrupted after ELS and associated with increased behavioral stress sensitivity, 2) putative transcriptional regulators of the effect of ELS on adult stress response, and 3) subsets of primed genes specifically associated with latent behavioral changes. We also provide transcriptomic evidence that ELS increases sensitivity to future stress through enhancement of known programs of cortical plasticity.

scholarly journals Effects of Early Life Stress on Epigenetic Changes of the Glucocorticoid Receptor 17 Promoter during Adulthood

2020 ◽  
Vol 21 (17) ◽  
pp. 6331
Author(s):  
Mi Kyoung Seo ◽  
Seon-gu Kim ◽  
Dae-Hyun Seog ◽  
Won-Myong Bahk ◽  
Seong-Ho Kim ◽  
...  
Keyword(s):  
Young Adult ◽  
Glucocorticoid Receptor ◽  
Histone Modification ◽  
Life Span ◽  
Histone Acetylation ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Epigenetic Changes ◽  
Immobility Time

Growing evidence suggests that early life stress (ELS) has long-lasting effects on glucocorticoid receptor (GR) expression and behavior via epigenetic changes of the GR exon 17 promoter. However, it remains unclear whether ELS regulates histone modifications of the GR exon 17 promoter across the life span. We investigated the effects of maternal separation (MS) on histone acetylation and methylation of GR exon 17 promoter in the hippocampus, according to the age of adults. Depression-like behavior and epigenetic regulation of GR expression were examined at young and middle adulthood in mice subjected to MS from postnatal day 1 to 21. In the forced swimming test, young adult MS mice showed no effect on immobility time, but middle-aged MS mice significantly increased immobility time. Young adult and middle-aged MS mice showed decreased GR expression. Their two ages showed decreased histone acetylation with increased histone deacetylases (HDAC5) levels, decreased permissive methylation, and increased repressive methylation at the GR exon 17 promoter. The extent of changes in gene expression and histone modification in middle adulthood was greater than in young adulthood. These results indicate that MS in early life causes long-term negative effects on behavior via histone modification of the GR gene across the life span.

Sign in / Sign up

Export Citation Format

Share Document