Influence of age and short-term starvation on the ATPase activity in the developing rat brain

The effect of a short-term oral administration of potassium cyanide (KCN) (200 ppm in diet) with or without sodium nitrite (NaNO2) pretreatment on rat brain microsomal Ca2± ATPase was investigated. The specific activity value of the enzyme significantly decreased (p<0.05) by 50% compared with control and by 63% for KCN-treated rats compared with KCN-treated rats pretreated with NaNO2. There was no significant difference at the h=0.05 level between the values obtained for the control and KCN-treated rats pretreated with NaNO2. These results show both that feeding lowers brain microsomal Ca2+-ATPase activity and that NaNO2 has a protective role (antidote function) in that respect.

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Temporal changes in the expression of brain-derived neurotrophic factor mRNA in the ventromedial nucleus of the hypothalamus of the developing rat brain

Molecular Brain Research ◽

10.1016/s0006-8993(03)02773-2 ◽

2003 ◽

Author(s):

N Sugiyama

Keyword(s):

Rat Brain ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Temporal Changes ◽

Ventromedial Nucleus ◽

Developing Rat

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Faculty Opinions recommendation of Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737530138.793572790 ◽

2020 ◽

Author(s):

Gustav Akk

Keyword(s):

Rat Brain ◽

Neuroactive Steroids ◽

Developing Rat

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Synthesis and turnover of cerebroside sulfate of myelin in adult and developing rat brain

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)36813-9 ◽

1974 ◽

Vol 15 (2) ◽

pp. 114-123 ◽

Cited By ~ 1

Author(s):

Firoze B. Jungalwala

Keyword(s):

Rat Brain ◽

Cerebroside Sulfate ◽

Developing Rat

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Regulation of tubulin by triiodothyronine in hypothyroid rat brain

Bioscience Reports ◽

10.1007/bf01116995 ◽

1985 ◽

Vol 5 (8) ◽

pp. 643-648 ◽

Cited By ~ 2

Author(s):

Anjana Mazumder ◽

Kamal Das ◽

Pranab K. Sarkar

Keyword(s):

Protein Synthesis ◽

Rat Brain ◽

Brain Maturation ◽

Normal Brain ◽

Neonatal Brain ◽

Organ Cultures ◽

Postnatal Brain ◽

Enhanced Sensitivity ◽

Brain Exposure ◽

Developing Rat

The effect of T3 (triiodothyronine) on the induction of tubulin in hypothyroid developing rat brain has been examined using organ cultures of brains from late fetal, neonatal and postnatalrats. The neonatal brain displayed maximum sensitivity to T3. Hypothyroidism resulted in a 26% decline in the level of tubulin in the neonatal brain as opposed to a 5–15% decline in the fetal or postnatal brain. Exposure of the hypothyroi d neonatal brain to T3 for 2 h in culture led to a 61% rise in the level of tubulin in contrast to a 41% increase seen in the case of normal brain. Total protein synthesis was not significantly affected. The preferential decline of tubulin in the neonatal hypothyroid brain, its enhanced sensitivity to T3 compared to normal brain, and the coincidence of the period of sensitivity to that of brain maturation indicate that the regulation of the level of tubulin by T3 in the developing brain is a natural ontogenic phenomenon.

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