Heart rate variability and the metabolic syndrome: a systematic review of the literature

Background: Because of the paucity of large randomised controlled trials (RCTs) in men with type 2 diabetes mellitus (T2DM) and/or the metabolic syndrome (MS), the majority of evidence for use of testosterone replacement therapy (TRT) on the cardiovascular (CV) system in such men is derived from observational studies and systematic reviews.Methods: We carried out an extensive retrospective review of the literature, comparing the major comparative trials that involved TRT in hypogonadal men with T2DM and/or MS and focused on CV outcomes.Results: Of 311 studies initially identified, 25 studies (12 RCTs and 13 non-RCTs) with a total number of 729,927 participants were deemed eligible for further review. Three RCTs and one non-RCT were excluded as these had not measured all-cause mortality and CV events as primary outcomes. Benefits of TRT on myocardial infarction were observed in two RCTs which were reviewed, while the rest demonstrated a neutral effect on CV events. In the non-RCTs, seven studies observed reduced all-cause mortality and/or major adverse CV events in the TRT group compared with the placebo group.Conclusions: This retrospective and systematic review of the literature suggests protective effects of TRT against all-cause mortality and major adverse cardiac events in hypogonadal men with T2DM and/or MS, although these results need to be interpreted cautiously.

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ASSOCIATION BETWEEN HEART RATE VARIABILITY AND COMPONENTS OF THE METABOLIC SYNDROME IN WOMEN WITH RHEUMATOID ARTHRITIS

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2014-10-1-18-24 ◽

2014 ◽

Vol 10 (1) ◽

pp. 18-24 ◽

Cited By ~ 1

Author(s):

D. S. Novikova ◽

T. V. Popkova ◽

A. N. Gerasimov ◽

A. V. Volkov ◽

E. L. Nasonov

Keyword(s):

Rheumatoid Arthritis ◽

Metabolic Syndrome ◽

Heart Rate ◽

Heart Rate Variability ◽

The Metabolic Syndrome

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Parent–Infant Skin-to-Skin Contact and Stress Regulation: A Systematic Review of the Literature

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094695 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4695

Author(s):

Chiara Ionio ◽

Giulia Ciuffo ◽

Marta Landoni

Keyword(s):

Systematic Review ◽

Heart Rate ◽

Heart Rate Variability ◽

Maternal Separation ◽

Biological Indicators ◽

Review Of The Literature ◽

Stress Regulation ◽

Skin Contact ◽

Neonatal Maternal Separation ◽

Skin To Skin

Several studies have focused on neonatal maternal separation (MS) to investigate behavioural and neuroendocrine reactions to lack of contact, but only a few have focused on early separation in the first days or weeks after birth. This literature review investigates the vital importance of contact and touch by exploring how skin-to-skin contact (SSC) regulates stress in the mother–infant relationship. Various databases such as PubMed, Scopus, and ScienceDirect were searched for literature published between 2015 and 2020. From 1141 articles, 22 were declared eligible. The reviewed articles showed how SSC regulates child stress by biological indicators such as the autonomic nervous system (ANS), heart rate variability (HRV), cortisol, and oxytocin. This research concludes the importance of SSC for stress regulation, especially during the COVID-19 pandemic. With no research to date indicating a possible risk of neonatal COVID-19 transmission following SSC, SSC should continue to be practiced for all women, as recommended by the WHO.

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