scholarly journals Differential expression of cyclic nucleotide phosphodiesterases 4 in developing rat lung

2010 ◽  
Vol 239 (9) ◽  
pp. 2470-2478 ◽  
Author(s):  
Emmanuel Lopez ◽  
Pierre-Henri Jarreau ◽  
Elodie Zana ◽  
Marie-Laure Franco-Montoya ◽  
Thomas Schmitz ◽  
...  
Keyword(s):  
Differential Expression ◽  
Cyclic Nucleotide ◽  
Rat Lung ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Developing Rat ◽  
Nucleotide Phosphodiesterases

Dihydro- and tetrahydroisoquinolines as inhibitors of cyclic nucleotide phosphodiesterases from dog heart

1979 ◽  
Vol 28 (8) ◽  
pp. 1307-1312 ◽  
Author(s):  
Richard G. van Inwegen ◽  
Phyllis Salaman ◽  
Vassil St. Georgiev ◽  
Ira Weinryb
Keyword(s):  
Cyclic Nucleotide ◽  
Dog Heart ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Nucleotide Phosphodiesterases

A Fluorescence Polarization Assay for Cyclic Nucleotide Phosphodiesterases

2002 ◽  
Vol 7 (3) ◽  
pp. 215-222 ◽  
Author(s):  
Wei Huang ◽  
Yan Zhang ◽  
J. Richard Sportsman
Keyword(s):  
Cyclic Nucleotide ◽  
Fluorescence Polarization ◽  
Drug Targets ◽  
Second Messengers ◽  
Reaction Products ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Extracellular Signals ◽  
Fluorescence Polarization Assay ◽  
Hydrolysis Of ◽  
Nucleotide Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of the 3′-ester bond of cyclic AMP (cAMP) and cyclic GMP (cGMP), important second messengers in the transduction of a variety of extracellular signals. There is growing interest in the study of PDEs as drug targets for novel therapeutics. We describe the development of a homogeneous fluorescence polarization assay for PDEs based on the strong binding of PDE reaction products (i.e., AMP or GMP) onto modified nanoparticles through interactions with immobilized trivalent metal cations. This assay technology (IMAP) is applicable to both cAMP- and cGMP-specific PDEs. Results of the assay in 384- and 1536-well microplates are presented.

Antiplatelet effects of KW-7, a new inhibitor of cyclic nucleotide phosphodiesterases

2004 ◽  
Vol 483 (2-3) ◽  
pp. 187-194 ◽  
Author(s):  
Chin-Chung Wu ◽  
Wei-Ya Wang ◽  
Reen-Yen Kuo ◽  
Fang-Rong Chang ◽  
Yang-Chang Wu
Keyword(s):  
Cyclic Nucleotide ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Nucleotide Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDE) 3 and 4 in normal, malignant, and HTLV-I transformed human lymphocytes

1999 ◽  
Vol 58 (6) ◽  
pp. 935-950 ◽  
Author(s):  
Dag Ekholm ◽  
James C Mulloy ◽  
Guang Gao ◽  
Eva Degerman ◽  
Genoveffa Franchini ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Human Lymphocytes ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Nucleotide Phosphodiesterases
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