scholarly journals TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor

2012 ◽  
Vol 241 (3) ◽  
pp. 505-521 ◽  
Author(s):  
Chris Wang ◽  
Laura Wilson-Berry ◽  
Tim Schedl ◽  
Dave Hansen
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Sex Determination ◽  
Germ Line ◽  
Splicing Factor ◽  
Stem Cell Proliferation ◽  
C Elegans

Two mutations in pab-1 encoding poly(A)-binding protein show similar defects in germline stem cell proliferation but different longevity in C. elegans

2010 ◽  
Vol 30 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Sunny Ko ◽  
Jae-Hyung Park ◽  
Ah-Reum Lee ◽  
Eugene Kim ◽  
Jiyoung-Kim ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Binding Protein ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
C Elegans

scholarly journals The exocyst complex regulates C. elegans germline stem cell proliferation by controlling membrane Notch levels

Development ◽  
2021 ◽  
Vol 148 (15) ◽  
Author(s):  
Kumari Pushpa ◽  
Sunayana Dagar ◽  
Harsh Kumar ◽  
Diksha Pathak ◽  
Sivaram V. S. Mylavarapu
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Plasma Membrane ◽  
Notch Signaling ◽  
Mammalian Cells ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
C Elegans ◽  
Exocyst Complex ◽  
Membrane Density

ABSTRACT The conserved exocyst complex regulates plasma membrane-directed vesicle fusion in eukaryotes. However, its role in stem cell proliferation has not been reported. Germline stem cell (GSC) proliferation in the nematode Caenorhabditis elegans is regulated by conserved Notch signaling. Here, we reveal that the exocyst complex regulates C. elegans GSC proliferation by modulating Notch signaling cell autonomously. Notch membrane density is asymmetrically maintained on GSCs. Knockdown of exocyst complex subunits or of the exocyst-interacting GTPases Rab5 and Rab11 leads to Notch redistribution from the GSC-niche interface to the cytoplasm, suggesting defects in plasma membrane Notch deposition. The anterior polarity (aPar) protein Par6 is required for GSC proliferation, and for maintaining niche-facing membrane levels of Notch and the exocyst complex. The exocyst complex biochemically interacts with the aPar regulator Par5 (14-3-3ζ) and Notch in C. elegans and human cells. Exocyst components are required for Notch plasma membrane localization and signaling in mammalian cells. Our study uncovers a possibly conserved requirement of the exocyst complex in regulating GSC proliferation and in maintaining optimal membrane Notch levels.

scholarly journals Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation

2016 ◽  
Vol 38 (1) ◽  
pp. 33-46 ◽  
Author(s):  
Snehal N. Chaudhari ◽  
Madhumati Mukherjee ◽  
Alexandra S. Vagasi ◽  
Gaofeng Bi ◽  
Mohammad M. Rahman ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
C Elegans

scholarly journals Non-autonomous regulation of germline stem cell proliferation by somatic MPK-1/MAPK activity in C. elegans

Cell Reports ◽  
2021 ◽  
Vol 35 (8) ◽  
pp. 109162
Author(s):  
Sarah Robinson-Thiewes ◽  
Benjamin Dufour ◽  
Pier-Olivier Martel ◽  
Xavier Lechasseur ◽  
Amani Ange Danielle Brou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
C Elegans ◽  
Mapk Activity ◽  
Autonomous Regulation

scholarly journals Non-autonomous regulation of germline stem cell proliferation by somatic MPK-1/MAPK activity in C. elegans

2020 ◽  
Author(s):  
Sarah Robinson-Thiewes ◽  
Benjamin Dufour ◽  
Pier-Olivier Martel ◽  
Xavier Lechasseur ◽  
Amani Ange Danielle Brou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Mitogen Activated Protein Kinase ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
C Elegans ◽  
Erk Mapk ◽  
Mapk Activity ◽  
Germline Differentiation ◽  
Germline Proliferation

AbstractExtracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) is a major positive regulator of cell proliferation that is often upregulated in cancer. Yet few studies have addressed ERK/MAPK regulation of proliferation within a complete organism. The C. elegans ERK/MAPK ortholog MPK-1 is best known for its control of somatic organogenesis and germline differentiation, but it also stimulates germline stem cell proliferation. Here we identify tissue-specific MPK-1 isoforms and characterize their distinct roles in germline function. The germline-specific MPK-1B isoform promotes germline differentiation, but has no apparent role in germline stem cell proliferation. By contrast, the soma-specific MPK-1A isoform promotes germline proliferation non-autonomously. Indeed, MPK-1A functions in the intestine or somatic gonad to promote germline proliferation, independently of its other known roles. We propose that a non-autonomous role of ERK/MAPK in stem cell proliferation may be conserved across species and other tissue types, with major clinical implications for cancer and other diseases.

scholarly journals The C. elegans CBF  homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal

Development ◽  
2007 ◽  
Vol 134 (21) ◽  
pp. 3905-3915 ◽  
Author(s):  
H. Kagoshima ◽  
R. Nimmo ◽  
N. Saad ◽  
J. Tanaka ◽  
Y. Miwa ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
C Elegans
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