scholarly journals The C. elegans CBF  homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal

Development ◽  
2007 ◽  
Vol 134 (21) ◽  
pp. 3905-3915 ◽  
Author(s):  
H. Kagoshima ◽  
R. Nimmo ◽  
N. Saad ◽  
J. Tanaka ◽  
Y. Miwa ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
C Elegans

Two mutations in pab-1 encoding poly(A)-binding protein show similar defects in germline stem cell proliferation but different longevity in C. elegans

2010 ◽  
Vol 30 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Sunny Ko ◽  
Jae-Hyung Park ◽  
Ah-Reum Lee ◽  
Eugene Kim ◽  
Jiyoung-Kim ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Binding Protein ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
C Elegans

scholarly journals Effects of Oxidative Stress on Mouse Embryonic Stem Cell Proliferation, Apoptosis, Senescence, and Self-Renewal

2010 ◽  
Vol 19 (9) ◽  
pp. 1321-1331 ◽  
Author(s):  
Yan-Lin Guo ◽  
Samujjwal Chakraborty ◽  
Suja S. Rajan ◽  
Rouxing Wang ◽  
Faqing Huang
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Self Renewal ◽  
Stem Cell Proliferation

Analysis of GPI-anchored proteins involved in germline stem cell proliferation in the Caenorhabditis elegans germline stem cell niche

2020 ◽  
Vol 168 (6) ◽  
pp. 589-602
Author(s):  
Marika Rikitake ◽  
Ayako Matsuda ◽  
Daisuke Murata ◽  
Katsufumi Dejima ◽  
Kazuko H Nomura ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Lipid Rafts ◽  
Stem Cell Niche ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
Cell Niche ◽  
Germline Stem Cell Niche

Abstract Stem cells divide and undergo self-renewal depending on the signals received from the stem cell niche. This phenomenon is indispensable to maintain tissues and organs in individuals. However, not all the molecular factors and mechanisms of self-renewal are known. In our previous study, we reported that glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) synthesized in the distal tip cells (DTCs; the stem cell niche) are essential for germline stem cell proliferation in Caenorhabditis elegans. Here, we characterized the GPI-APs required for proliferation. We selected and verified the candidate GPI-APs synthesized in DTCs by RNA interference screening and found that F57F4.3 (GFI-1), F57F4.4 and F54E2.1 are necessary for germline proliferation. These proteins are likely involved in the same pathway for proliferation and activated by the transcription factor PQM-1. We further provided evidence suggesting that these GPI-APs act through fatty acid remodelling of the GPI anchor, which is essential for association with lipid rafts. These findings demonstrated that GPI-APs, particularly F57F4.3/4 and F54E2.1, synthesized in the germline stem cell niche are located in lipid rafts and involved in promoting germline stem cell proliferation in C. elegans. The findings may thus shed light on the mechanisms by which GPI-APs regulate stem cell self-renewal.

scholarly journals The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation

2012 ◽  
Vol 3 (4) ◽  
pp. 291-304 ◽  
Author(s):  
Huan Liu ◽  
Dandan Jiang ◽  
Fangtao Chi ◽  
Bin Zhao
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hippo Pathway ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
The Hippo Pathway
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