Extensive habitat loss and habitat conversion has occurred across all mediterranean-type climate (MTC) regions, driven by increasing human populations who have converted large tracts of land to production, transport, and residential use (land-use, land-cover change) while simultaneously introducing novel forms of disturbance to natural landscapes. Remaining habitat, often fragmented and in isolated or remote (mountainous) areas, is threatened and degraded by altered fire regimes, introduction of invasive species, nutrient enrichment, and climate change. The types and impacts of these threats vary across MTC regions, but overall these drivers of change show little signs of abatement and many have the potential to interact with MTC region natural systems in complex ways.