scholarly journals Prognostic impact of hospital‐acquired disability in elderly patients with heart failure

2021 ◽  
Author(s):  
Masakazu Saitoh ◽  
Yuta Takahashi ◽  
Daisuke Okamura ◽  
Mitsutoshi Akiho ◽  
Hidetoshi Suzuki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patients ◽  
Prognostic Impact ◽  
Acquired Disability ◽  
Patients With Heart Failure ◽  
Hospital Acquired

PROGNOSTIC IMPACT OF GERIATRIC NUTRITIONAL RISK INDEX IN ELDERLY PATIENTS WITH HEART FAILURE

2019 ◽  
Vol 73 (9) ◽  
pp. 1807
Author(s):  
Takahiro Okano ◽  
Hirohiko Motoki ◽  
Masatoshi Minamisawa ◽  
Kazuhiro Kimura ◽  
Soichiro Ebisawa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patients ◽  
Risk Index ◽  
Nutritional Risk ◽  
Prognostic Impact ◽  
Geriatric Nutritional Risk Index ◽  
Nutritional Risk Index ◽  
Patients With Heart Failure

scholarly journals Prevalence and prognostic impact of the coexistence of multiple frailty domains in elderly patients with heart failure: the FRAGILE‐HF cohort study

2020 ◽  
Vol 22 (11) ◽  
pp. 2112-2119 ◽  
Author(s):  
Yuya Matsue ◽  
Kentaro Kamiya ◽  
Hiroshi Saito ◽  
Kazuya Saito ◽  
Yuki Ogasahara ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cohort Study ◽  
Elderly Patients ◽  
Prognostic Impact ◽  
Patients With Heart Failure

scholarly journals Prevalence and prognostic impact of frailty and its components in non-dependent elderly patients with heart failure

2016 ◽  
Vol 18 (7) ◽  
pp. 869-875 ◽  
Author(s):  
María T. Vidán ◽  
Vendula Blaya-Novakova ◽  
Elísabet Sánchez ◽  
Javier Ortiz ◽  
José A. Serra-Rexach ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patients ◽  
Prognostic Impact ◽  
Patients With Heart Failure ◽  
Dependent Elderly

310 Multidisciplinary management of elderly patients with heart failure in a day hospital

2007 ◽  
Vol 6 (1) ◽  
pp. 68-68
Author(s):  
N MUNOZRIVAS ◽  
M MENDEZ ◽  
P MONTEJODEGARCINI ◽  
A YERA ◽  
M CANO ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patients ◽  
Multidisciplinary Management ◽  
Day Hospital ◽  
Patients With Heart Failure

Application of WHOQOL-BREF for the evaluation of the quality of life in elderly patients with heart failure

2016 ◽  
Vol 9 (4) ◽  
pp. 878-883 ◽  
Author(s):  
Mahshid Borumandpour Gholamabbas Valizadeh ◽  
Alizallah Dehghan ◽  
Alireza Poumarjani ◽  
Maryam Ahmadifar
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Elderly Patients ◽  
Patients With Heart Failure

Prevalence and prognostic impact of somatic mutations in patients with heart failure and reduced ejection fraction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D.J Vazquez Andres ◽  
A Hernandez Vicente ◽  
M Diez Diez ◽  
M Gomez Molina ◽  
A Quintas ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Somatic Mutations ◽  
Myocardial Dysfunction ◽  
Study Endpoint ◽  
Prognostic Impact ◽  
Reduced Ejection Fraction ◽  
Increased Risk ◽  
Patients With Heart Failure

Abstract Introduction Somatic mutations in hematopoietic cells are associated with age and have been associated with higher mortality in apparently healthy adults, especially due to atherosclerotic disease. In animal models, somatic mutations are associated with atherosclerosis progression and myocardial dysfunction, especially when gene TET2 is affected. Preliminary clinical data, referred to ischemic heart failure (HF), have associate the presence of these acquired mutations with impaired prognosis. Purpose To study the prevalence of somatic mutations in patients with heart failure with reduced ejection fraction (HFrEF) and their impact on long-term prognosis. Methods We studied a cohort of elderly patients (more than 60 years old) hospitalized with HFrEF (LVEF<45%). The presence of somatic mutations was assessed using next generation sequencing (Illumina HiSeq 2500), with a mutated allelic fraction of at least 2% and a panel of 55 genes related with clonal hematopoiesis. Patients were followed-up for a median of three years. The study endpoint was a composite of death or readmission for worsening HF. Kaplan-Meier analysis (log-rank test) and Cox proportional hazards regression models were performed adjusting for age, sex and LVEF. Results A total of 62 patients (46 males (74.2%), age 74±7.5 years) with HFrEF (LVEF 29.7±7.8%) were enrolled in the study. The ischemic etiology was present in 54% of patients. Somatic mutations in Dnmt3a or Tet2 were present in 11 patients (17.7%). No differences existed in baseline characteristics except for a higher prevalence of atrial fibrillation in patients with somatic mutations (70% vs. 40%, p=0.007). During the follow-up period, 40 patients (64.5%) died and 38 (61.3%) had HF re-admission. The KM survival analysis for the combined event is shown in Figure 1. Compared with patients without somatic mutations and after adjusting for covariates, there was an increased risk of adverse outcomes when the somatic mutations were present (HR 3.6, 95% CI [1.6, 7.8], p=0.0014). This results remains considering death as a competing risk (Gray's test p=0.0097) and adjusting for covariates (HR = 2.21 95% CI [0.98, 5], p=0.0556). Conclusions Somatic mutation are present in patients with HFrEF and determine a higher risk of adverse events in the follow-up. Further studies are needed to assess the clinical implications of these findings. Figure 1 Funding Acknowledgement Type of funding source: None

Improvement of Ventricular-Arterial Coupling in Elderly Patients with Heart Failure After Beta Blocker Therapy: Results from the CIBIS-ELD Trial

2015 ◽  
Vol 29 (3) ◽  
pp. 287-294 ◽  
Author(s):  
Milica Dekleva ◽  
Jelena Suzic Lazic ◽  
Ivan Soldatovic ◽  
Simone Inkrot ◽  
Aleksandra Arandjelovic ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patients ◽  
Beta Blocker ◽  
Blocker Therapy ◽  
Beta Blocker Therapy ◽  
Patients With Heart Failure
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