Rationale and design of the phase 2b clinical trials to study the effects of the partial adenosine A1-receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced (PANTHEON) and preserved (PANACHE) ejection fraction

Adriaan A. Voors; Sanjiv J. Shah; Jeroen J. Bax; Javed Butler; Mihai Gheorghiade; Adrian F. Hernandez; Dalane W. Kitzman; John J.V. McMurray; Antonieta Bomfim Wirtz; Vivian Lanius; Michael van der Laan; Scott D. Solomon

doi:10.1002/ejhf.1295

Rationale and design of the phase 2b clinical trials to study the effects of the partial adenosine A1-receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced (PANTHEON) and preserved (PANACHE) ejection fraction

European Journal of Heart Failure ◽

10.1002/ejhf.1295 ◽

2018 ◽

Vol 20 (11) ◽

pp. 1601-1610 ◽

Cited By ~ 15

Author(s):

Adriaan A. Voors ◽

Sanjiv J. Shah ◽

Jeroen J. Bax ◽

Javed Butler ◽

Mihai Gheorghiade ◽

...

Keyword(s):

Heart Failure ◽

Clinical Trials ◽

Chronic Heart Failure ◽

Ejection Fraction ◽

Receptor Agonist ◽

Adenosine A1 Receptor ◽

Adenosine A1 ◽

A1 Receptor

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The Partial AdeNosine A1 receptor agonist in patients with Chronic Heart failure and preserved Ejection fraction (PANACHE) trial

Cardiovascular Research ◽

10.1093/cvr/cvz123 ◽

2019 ◽

Vol 115 (8) ◽

pp. e71-e73 ◽

Cited By ~ 2

Author(s):

Edoardo Bertero ◽

Christoph Maack

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Ejection Fraction ◽

Receptor Agonist ◽

Adenosine A1 Receptor ◽

Preserved Ejection Fraction ◽

Adenosine A1 ◽

A1 Receptor

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Safety and Tolerability of Neladenoson Bialanate, a Novel Oral Partial Adenosine A1 Receptor Agonist, in Patients With Chronic Heart Failure

The Journal of Clinical Pharmacology ◽

10.1002/jcph.828 ◽

2016 ◽

Vol 57 (4) ◽

pp. 440-451 ◽

Cited By ~ 24

Author(s):

Adriaan Alexander Voors ◽

Hans-Dirk Düngen ◽

Michele Senni ◽

Savina Nodari ◽

Piergiuseppe Agostoni ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Receptor Agonist ◽

Adenosine A1 Receptor ◽

Adenosine A1 ◽

A1 Receptor

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Chronic Therapy With a Partial Adenosine A1-Receptor Agonist Improves Left Ventricular Function and Remodeling in Dogs With Advanced Heart Failure

Circulation Heart Failure ◽

10.1161/circheartfailure.112.000208 ◽

2013 ◽

Vol 6 (3) ◽

pp. 563-571 ◽

Cited By ~ 47

Author(s):

Hani N. Sabbah ◽

Ramesh C. Gupta ◽

Smita Kohli ◽

Mengjun Wang ◽

Sharad Rastogi ◽

...

Keyword(s):

Heart Failure ◽

Left Ventricular Function ◽

Ventricular Function ◽

Receptor Agonist ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Adenosine A1 Receptor ◽

Chronic Therapy ◽

Adenosine A1 ◽

A1 Receptor

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Safety and efficacy of the partial adenosine A1 receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced ejection fraction: a phase IIb, randomized, double‐blind, placebo‐controlled trial

European Journal of Heart Failure ◽

10.1002/ejhf.1591 ◽

2019 ◽

Vol 21 (11) ◽

pp. 1426-1433 ◽

Cited By ~ 6

Author(s):

Adriaan A. Voors ◽

Jeroen J. Bax ◽

Adrian F. Hernandez ◽

Antonieta B. Wirtz ◽

Akos F. Pap ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Receptor Agonist ◽

Controlled Trial ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo ◽

Reduced Ejection Fraction ◽

Adenosine A1 ◽

A1 Receptor

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Effects of rolofylline, a new adenosine A1 receptor antagonist, on symptoms, renal function and outcomes in patients with acute heart failure. Results of the PROTECT pilot study

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(08)60149-6 ◽

2008 ◽

Vol 7 ◽

pp. 53-54

Author(s):

C OCONNOR ◽

G COTTER ◽

H DITTRICH ◽

B DAVISONWEATHERLEY ◽

M METRA ◽

...

Keyword(s):

Heart Failure ◽

Renal Function ◽

Pilot Study ◽

Receptor Antagonist ◽

Acute Heart Failure ◽

Adenosine A1 Receptor ◽

Adenosine A1 ◽

A1 Receptor

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Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes

Behavioural Pharmacology ◽

10.1097/fbp.0000000000000091 ◽

2014 ◽

Vol 25 (8) ◽

pp. 741-749 ◽

Cited By ~ 2

Author(s):

Guillermo A. Ramos-Zepeda ◽

Carlos Herrero-Zorita ◽

Juan F. Herrero

Keyword(s):

Spinal Cord ◽

Opioid Receptors ◽

Receptor Agonist ◽

Adenosine A1 Receptor ◽

Rat Spinal Cord ◽

Adenosine A1 ◽

Nociceptive Reflexes ◽

A1 Receptor

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Role of ATP-sensitive K+ channels in antinociception induced by R-PIA, an adenosine A1 receptor agonist

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/bf00180011 ◽

1994 ◽

Vol 350 (1) ◽

Cited By ~ 24

Author(s):

Mar�a Oca�a ◽

Jos�M. Baeyens

Keyword(s):

Receptor Agonist ◽

Adenosine A1 Receptor ◽

K Channels ◽

Adenosine A1 ◽

A1 Receptor

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The interaction of morphine and adenosine A1 receptor agonist (R-PIA) in a rat model of postoperative pain

Regional Anesthesia and Pain Medicine ◽

10.1097/00115550-200409002-00190 ◽

2004 ◽

Vol 29 (Sup 2) ◽

pp. 100

Author(s):

J-Y Park ◽

J-H Hwang

Keyword(s):

Postoperative Pain ◽

Rat Model ◽

Receptor Agonist ◽

Adenosine A1 Receptor ◽

Adenosine A1 ◽

A1 Receptor

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Microinjection of the adenosine A1 receptor agonist N6-p-sulfophenyladenosine (SPA) into the pontine reticular formation (PRF) of C57BL/6J mouse increases antinociception in a concentration-dependent manner

Journal of Pain ◽

10.1016/j.jpain.2012.01.189 ◽

2012 ◽

Vol 13 (4) ◽

pp. S45

Author(s):

S. Watson ◽

M. Frank ◽

C. Watson ◽

H. Baghdoyan ◽

R. Lydic

Keyword(s):

Reticular Formation ◽

Receptor Agonist ◽

Adenosine A1 Receptor ◽

Dependent Manner ◽

Pontine Reticular Formation ◽

Concentration Dependent Manner ◽

Adenosine A1 ◽

A1 Receptor

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The adenosine A1 receptor agonist N6-cyclopentyladenosine blocks the disruptive effect of phencyclidine on prepulse inhibition of the acoustic startle response in the rat

European Journal of Pharmacology ◽

10.1016/s0014-2999(99)00088-6 ◽

1999 ◽

Vol 369 (3) ◽

pp. 325-329 ◽

Cited By ~ 18

Author(s):

Terrence L. Sills ◽

Arezou Azampanah ◽

Paul J. Fletcher

Keyword(s):

Prepulse Inhibition ◽

Startle Response ◽

Receptor Agonist ◽

Acoustic Startle ◽

Acoustic Startle Response ◽

Adenosine A1 Receptor ◽

Disruptive Effect ◽

Adenosine A1 ◽

A1 Receptor

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