Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes

1992 ◽  
Vol 22 (4) ◽  
pp. 903-907 ◽  
Author(s):  
Joanne Morrison ◽  
John Elvin ◽  
France Latron ◽  
Frances Gotch ◽  
Robert Moots ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Influenza A ◽  
Matrix Protein ◽  
Nonamer Peptide

Recognition by HLA-A2-restricted cytotoxic T lymphocytes of endogenously generated and exogenously provided synthetic peptide analogues of the influenza a virus matrix protein

1993 ◽  
Vol 37 (4) ◽  
pp. 252-258 ◽  
Author(s):  
Samir Y. Sauma ◽  
Maureen C. Gammon ◽  
Maria A. Bednarek ◽  
Barry Cunningham ◽  
William E. Biddison ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Influenza A Virus ◽  
Cytotoxic T Lymphocytes ◽  
Synthetic Peptide ◽  
Influenza A ◽  
Matrix Protein ◽  
Peptide Analogues

scholarly journals Recognition of influenza A matrix protein by HLA-A2-restricted cytotoxic T lymphocytes. Use of analogues to orientate the matrix peptide in the HLA-A2 binding site.

1988 ◽  
Vol 168 (6) ◽  
pp. 2045-2057 ◽  
Author(s):  
F Gotch ◽  
A McMichael ◽  
J Rothbard
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
T Lymphocytes ◽  
Influenza A Virus ◽  
Cytotoxic T Lymphocytes ◽  
Influenza A ◽  
Matrix Protein ◽  
Single Amino Acid ◽  
The Matrix ◽  
Natural Peptide

CTL specific for the influenza A virus matrix peptide 57-68 and restricted by HLA-A2 were studied. Their ability to recognize a set of analogue peptides, each of which differed from the natural peptide by a single amino acid, was analyzed. This revealed a core of five amino acids, 61-65, where one or more changes completely abrogated recognition. The glycine at position 61 was the only residue where no substitution was tolerated. Analogue peptides that did not induce CTL-mediated lysis were tested as competitors with the natural peptide; those with substitutions at positions 60, 64, and 65 inhibited, identifying residues that interact with the TCR. Another approach was to test a set of four CTL clones on all of the analogues. Marked differences in recognition by individual CTL clones were observed for several substituted peptides. The data indicate that most of the analogues bind to HLA-A2 with possible differences in fine positioning of the peptide. An alpha helical orientation for the peptide is discussed.

scholarly journals Positive role of macaque cytotoxic T lymphocytes during SIV infection: decrease of cellular viremia and increase of asymptomatic clinical period

1997 ◽  
Vol 19 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Isabelle Bourgault Villada ◽  
Lorenzo Mortara ◽  
Anne Marie Aubertin ◽  
Hélène Gras-Masse ◽  
Jean Paul Lévy ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Positive Role ◽  
Siv Infection

scholarly journals HLA restriction of human cytotoxic T lymphocytes specific for influenza virus. Poor recognition of virus associated with HLA A2.

1978 ◽  
Vol 148 (6) ◽  
pp. 1458-1467 ◽  
Author(s):  
A McMichael
Keyword(s):  
Influenza Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Influenza A ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
The Other ◽  
Target Cells ◽  
Surface Molecules ◽  
Human Peripheral Blood Lymphocytes

Cytotoxic T lymphocytes (CTL), specific for influenza A/X31 virus, were generated from human peripheral blood lymphocytes. These CTL lysed target cells that were infected with the same virus and that shared HLA A or B locus antigens. Minimal lysis was observed when HLA-D antigens were shared. Not all HLA A and B antigens were equally effective. Efficient lysis of target cells was seen when HLA A1, A3, B7, B8, B27 and BW21 were shared with the CTL, but when HLA A2 was the only shared antigen lysis was usually minimal. This deficiency in CTL function associated with HLA A2 was not absolute. It is suggested that the function of this antigen might be influenced by other surface molecules on the cell and in particular the other HLA products.

scholarly journals Role of CD8 Cytotoxic T Lymphocytes in Hepatocellular Carcinoma: An Immunohistochemical Study

2019 ◽  
Vol 87 (12) ◽  
pp. 4061-4069
Author(s):  
ASMAA G. ABDOU, M.D.; HALA S. EL-REBEY, M.D. ◽  
NANIS S. HOLAH, M.D.; MERVAT S. SULTAN, M.D. ◽  
SHYMAA H. IBRAHIM, M.Sc.
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Immunohistochemical Study

N-linked oligosaccharides can protect target cells from the lysis mediated by NK cells but not by cytotoxic T lymphocytes: role of NKG2-A

1999 ◽  
Vol 54 (2) ◽  
pp. 113-121 ◽  
Author(s):  
M.-A. Sol ◽  
N. Vacaresse ◽  
J. Lule ◽  
C. Davrinche ◽  
B. Gabriel ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Nk Cells ◽  
Cytotoxic T Lymphocytes ◽  
Target Cells
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