The Role of Cytotoxic T Lymphocytes in Human T-cell Lymphotropic Virus Type 1 Infection

2000 ◽  
Vol 207 (1) ◽  
pp. 65-79 ◽  
Author(s):  
BECCA ASQUITH ◽  
CHARLES R.M. BANGHAM
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Virus Type ◽  
Human T Cell

scholarly journals Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma

2020 ◽  
Vol 13 (2) ◽  
pp. 802-806
Author(s):  
Tatsuro Jo ◽  
Yohei Kaneko ◽  
Takayuki Oishi ◽  
Kaori Matsuzaka ◽  
Haruna Shioya ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Virus Type ◽  
Hepatitis Virus ◽  
Cell Leukemia ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia ◽  
Type C

Herein, we present the case of a patient who suffered from adult T-cell leukemia/lymphoma (ATLL) and hepatocellular carcinoma (HCC) after obtaining a sustained virological response following treatment with a direct-acting antiviral (DAA) at different points in time. The patient went into complete remission (CR) for ATLL. Unfortunately, subsequent relapse of ATLL was observed. This situation was overcome using chemotherapy with pegylated interferon alpha-2b. Human T lymphotropic virus type 1 Tax-specific cytotoxic T lymphocytes (CTLs) were recognized after obtaining second CR, and those CTLs have been maintained for many years. After 4 years from the second CR, chronic hepatitis type C was treated with a DAA, and sustained virological response was attained. However, the occurrence of HCC was detected. Surprisingly, the tumor disappeared spontaneously. Hepatitis virus type C-specific CTLs were also detected in the patient. T-cell receptor (TCR) V beta gene repertoire analyses revealed oligoclonal expansion of effector and memory CTLs. The number of CTLs expressing the TCR V beta 13.1 has increased over the years since HCC occurrence. The activation and maintenance of anticancer cellular immunity may have allowed the patient to obtain long-term survival and overcome two lethal neoplasms.

scholarly journals The Role of ITCH Protein in Human T-cell Leukemia Virus Type 1 Release

2011 ◽  
Vol 286 (36) ◽  
pp. 31092-31104 ◽  
Author(s):  
Batsukh Dorjbal ◽  
David Derse ◽  
Patricia Lloyd ◽  
Ferri Soheilian ◽  
Kunio Nagashima ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Immortalization of CD4+ and CD8+ T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone

1999 ◽  
Vol 73 (6) ◽  
pp. 4856-4865 ◽  
Author(s):  
Michael D. Robek ◽  
Lee Ratner
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Virus Type ◽  
Leukemia Virus ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Molecular Clone ◽  
Human T Cell ◽  
T Cell Leukemia Virus

ABSTRACT The human T-cell leukemia virus type 1 (HTLV-1) transcriptionaltrans-activator Tax has been demonstrated to have transforming activity in multiple cell culture and transgenic-mouse models. In addition to activating transcription from the viral long terminal repeat (LTR) through the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors, Tax activates the expression of multiple cellular promoters through the NF-κB pathway of transcriptional activation. The Tax mutants M22 and M47 have previously been demonstrated to selectively abrogate the ability of Tax to activate transcription through the NF-κB or CREB/ATF pathway, respectively. These mutations were introduced in the tax gene of the ACH functional molecular clone of HTLV-1, and virus produced from the mutant ACH clones was examined for the ability to replicate and immortalize primary human lymphocytes. While virus derived from the clone containing the M47 mutation retained the ability to immortalize T lymphocytes, the M22 mutant lost the ability to immortalize infected cells. These results indicate that activation of the CREB/ATF pathway by Tax is dispensable for the immortalization of T cells by HTLV-1, whereas activation of the NF-κB pathway may be critical.

scholarly journals A Chimeric Human T-Cell Lymphotropic Virus Type 1 with the Envelope Glycoprotein of Moloney Murine Leukemia Virus Is Infectious for Murine Cells

2002 ◽  
Vol 76 (15) ◽  
pp. 7883-7889 ◽  
Author(s):  
Frédéric Delebecque ◽  
Karin Pramberger ◽  
Marie-Christine Prévost ◽  
Michel Brahic ◽  
Frédéric Tangy
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Virus Type ◽  
Envelope Glycoprotein ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Moloney Murine Leukemia Virus ◽  
Human T Cell ◽  
Murine Leukemia

ABSTRACT We constructed a chimeric human T-cell lymphotropic virus type 1 (HTLV-1) provirus in which the original envelope precursor sequence was replaced by that of ecotropic Moloney murine leukemia virus (Mo-MuLV). Chimeric particles produced by transient transfection of this chimeric provirus were infectious for murine cells, such as NIH 3T3 fibroblasts, lymphoid EL4 cells, and primary CD4+ T lymphocytes, whereas HTLV-1 particles were not. The infectivity of chimeric particles increased 10 times when the R peptide located at the carboxy terminus of the MuLV envelope glycoprotein was deleted. Primary murine CD4+ T lymphocytes, infected by the ΔR chimeric virus, released particles that could spread the infection to other naive murine lymphoid cells. This chimeric virus, with the Mo-MuLV envelope glycoprotein and the replication characteristics of HTLV-1, should be useful in studying the pathogenesis of HTLV-1 in a mouse model.

scholarly journals Immune Response against the Exp-1 Protein of Plasmodium falciparum Results in Antibodies That Cross-React with Human T-Cell Lymphotropic Virus Type 1 Proteins

1998 ◽  
Vol 5 (5) ◽  
pp. 721-724 ◽  
Author(s):  
Kevin R. Porter ◽  
Joao Aguiar ◽  
Allen Richards ◽  
B. Sandjaya ◽  
H. Ignatias ◽  
...  
Keyword(s):  
Immune Response ◽  
Plasmodium Falciparum ◽  
T Cell ◽  
Western Blot ◽  
Virus Type ◽  
False Positive ◽  
Type I ◽  
Human T Cell

ABSTRACT To examine the role of the Plasmodium falciparum Exp-1 blood-stage protein in producing antibodies that cross-react with human T-cell lymphotropic virus type I (HTLV-I) proteins, we studied sera from Indonesian volunteers who seroconverted to malaria after transmigrating to an area where malaria is hyperendemic. Samples from Philippine volunteers, that were used in a prior study that examined malaria antibodies that cross-react with HTLV-I proteins, were also used. Eighty-three percent of the Indonesian transmigrants developed antibodies against the malaria Exp-1 protein by 6 months postmigration. Of these malaria seroconverters, 27% developed false-positive HTLV-I enzyme immunoassay (EIA) immunoreactivity, as indicated by indeterminate HTLV-I Western blot banding patterns. Five of the six Philippine samples tested were HTLV-I EIA false positive and Western blot indeterminate. When a recombinant Exp-1 protein was used in blocking experiments, the HTLV-I Western blot immunoreactivity of sera from both groups was either completely eliminated or greatly reduced. No effect on the Western blot immunoreactivity of truly HTLV-I-positive sera was seen. To determine if immunization with the recombinant Exp-1 protein could elicit the production of HTLV-I antibodies, six mice were inoculated with the recombinant protein. Following administration of three 50-μg doses of the protein, four of the six mice developed antibodies that cross-reacted with HTLV-I proteins on Western blot. These results indicate that the immune response against the malaria Exp-1 protein may result in HTLV-I-cross-reacting antibodies that can lead to false-positive EIA and indeterminant Western blotting results.

Circulating Endothelial Progenitor Cells Is Increasing in Human T Cell Lymphotropic Virus Type 1 (HTLV1) Asymptomatic Carriers

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5474-5474
Author(s):  
Ana Luisa Langanke Pedroso Meireles ◽  
Dalton Chamone ◽  
Carla Rosa Teixeira Godoy ◽  
Juliana Pereira
Keyword(s):  
Endothelial Cells ◽  
T Cell ◽  
Growth Factor ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Virus Type ◽  
Control Group ◽  
Human T Cell

Abstract The role of angiogenesis in metastasis of solid tumors is well established, but not in hematologic malignancies. Marwan et al demonstrated that Human T Cell Lymphotropic Virus Type 1 (HTLV1) transformed T cells secrete vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and induce angiogenesis in vitro. Adult T-cell leukemia-lymphoma (ATL) leukemic cells produce VEGF and bFGF proteins. Therefore, the role of angiogenesis in ATL development is under investigation. We interested whether endothelial progenitor cells (EPCs) and mature endothelial cells (ECs) contribute to tumor angiogenesis in ATL Thought, this cross-sectional study aimed at quantifying circulating endothelial cells in the blood of HTLV1 asymptomatic carriers in comparison to healthy individuals by flow cytometry. A sample of 30 HTLV1 carrier age and sex matched has been compared to the control group. We demonstrated that the EPCs values were greater in the asymptomatic HTLV1 carrier (median 0.8288 cells/mm3) rather than to the control group (median 0.4905 cells/mm3) (p = 0.035). We identified other pathway of the angiogenesis in HTLV1 carriers. However, others studies are necessary to confirm the role of EPCs in the ATL pathogenesis.

Sign in / Sign up

Export Citation Format

Share Document