In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production

1996 ◽  
Vol 26 (9) ◽  
pp. 2062-2066 ◽  
Author(s):  
James M. Brewer ◽  
Margaret Conacher ◽  
Abhay Satoskar ◽  
Horst Bluethmann ◽  
James Alexander
Keyword(s):  
Cytokine Production ◽  
Interleukin 4 ◽  
T Helper ◽  
T Helper 1 ◽  
Freund’S Complete Adjuvant ◽  
T Helper 2 ◽  
Freund's Complete Adjuvant ◽  
Deficient Mice

scholarly journals High Levels of Susceptibility and T Helper 2 Response in MyD88-Deficient Mice Infected with Leishmania major Are Interleukin-4 Dependent

2003 ◽  
Vol 71 (12) ◽  
pp. 7215-7218 ◽  
Author(s):  
Andrea Debus ◽  
Joachim Gläsner ◽  
Martin Röllinghoff ◽  
André Gessner
Keyword(s):  
Knockout Mice ◽  
Leishmania Major ◽  
Parasite Burden ◽  
Interleukin 4 ◽  
Myeloid Differentiation ◽  
Interleukin 12 ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Deficient Mice

ABSTRACT Myeloid differentiation protein 88 (MyD88) is a general adaptor for the signaling cascade through receptors of the Toll/IL-1R family. When infected with Leishmania major parasites, MyD88-deficient mice displayed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice. In contrast, MyD88 knockout mice did not develop ulcerating lesions despite a lack of interleukin-12 (IL-12) production and a predominant T helper 2 cell response. Blockade of IL-4 produced early (day 1) after infection restored a protective T helper 1 response in MyD88 knockout mice.

Measles virus-specific T helper 1/T helper 2-cytokine production in subacute sclerosing panencephalitis

2000 ◽  
Vol 6 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Toshiro Hara ◽  
Sumimasa Yamashita ◽  
Hideo Aiba ◽  
Kenji Nihei ◽  
Nobuo Koide ◽  
...  
Keyword(s):  
Measles Virus ◽  
Cytokine Production ◽  
Subacute Sclerosing Panencephalitis ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2

Divergent Effects of Interleukin-4 and Interferon-γ on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses

Blood ◽  
1998 ◽  
Vol 92 (8) ◽  
pp. 2668-2671 ◽  
Author(s):  
Raffaella Bonecchi ◽  
Silvano Sozzani ◽  
Johnny T. Stine ◽  
Walter Luini ◽  
Giovanna D’Amico ◽  
...  
Keyword(s):  
Constitutive Expression ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Th2 Cells ◽  
Mrna Levels ◽  
T Helper ◽  
T Helper 1 ◽  
Chemokine Production ◽  
T Helper 2 ◽  
Ifn Γ

Macrophage-derived chemokine (MDC) is a CC chemokine that recognizes the CCR4 receptor and is selective for T helper 2 (Th2) versus T helper 1 (Th1) cells. The present study was designed to investigate the effect of the prototypic Th2/Th1 cytokines, interleukin-4 (IL-4) and interferon-γ (IFN-γ), on the production of MDC by human monocytes. IL-4 and IL-13 caused a time-dependent (plateau at 24 hours) and concentration-dependent (EC50 2 and 10 ng/mL, respectively) increase of MDC mRNA levels in monocytes. Increased expression of MDC mRNA was associated with protein release in the supernatant. MDC expression and production induced by IL-4 and IL-13 were inhibited by IFN-γ. IFN-γ also suppressed the constitutive expression of MDC in mature macrophages and dendritic cells. These results delineate an amplification loop of polarized Th2 responses based on differential regulation of MDC production by IL-4 and IL-13 versus IFN-γ and on the selectivity of this chemokine for polarized Th2 cells. © 1998 by The American Society of Hematology.

Nigella sativa (black seed) oil does not affect the T-helper 1 and T-helper 2 type cytokine production from splenic mononuclear cells in allergen sensitized mice

2005 ◽  
Vol 100 (3) ◽  
pp. 295-298 ◽  
Author(s):  
Suna Büyüköztürk ◽  
Aslı Gelincik ◽  
Ferhan Özşeker ◽  
Sema Genç ◽  
Fatma Oğuz Şavran ◽  
...  
Keyword(s):  
Seed Oil ◽  
Mononuclear Cells ◽  
Cytokine Production ◽  
Nigella Sativa ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Black Seed ◽  
Black Seed Oil

Divergent Effects of Interleukin-4 and Interferon-γ on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses

Blood ◽  
1998 ◽  
Vol 92 (8) ◽  
pp. 2668-2671 ◽  
Author(s):  
Raffaella Bonecchi ◽  
Silvano Sozzani ◽  
Johnny T. Stine ◽  
Walter Luini ◽  
Giovanna D’Amico ◽  
...  
Keyword(s):  
Constitutive Expression ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Th2 Cells ◽  
Mrna Levels ◽  
T Helper ◽  
T Helper 1 ◽  
Chemokine Production ◽  
T Helper 2 ◽  
Ifn Γ

Abstract Macrophage-derived chemokine (MDC) is a CC chemokine that recognizes the CCR4 receptor and is selective for T helper 2 (Th2) versus T helper 1 (Th1) cells. The present study was designed to investigate the effect of the prototypic Th2/Th1 cytokines, interleukin-4 (IL-4) and interferon-γ (IFN-γ), on the production of MDC by human monocytes. IL-4 and IL-13 caused a time-dependent (plateau at 24 hours) and concentration-dependent (EC50 2 and 10 ng/mL, respectively) increase of MDC mRNA levels in monocytes. Increased expression of MDC mRNA was associated with protein release in the supernatant. MDC expression and production induced by IL-4 and IL-13 were inhibited by IFN-γ. IFN-γ also suppressed the constitutive expression of MDC in mature macrophages and dendritic cells. These results delineate an amplification loop of polarized Th2 responses based on differential regulation of MDC production by IL-4 and IL-13 versus IFN-γ and on the selectivity of this chemokine for polarized Th2 cells. © 1998 by The American Society of Hematology.

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