Application of a geographic information system to explore associations between air pollution and micronucleus frequencies in African American children and adults

2006 ◽  
Vol 47 (4) ◽  
pp. 236-246 ◽  
Author(s):  
Karen Huen ◽  
Laura Gunn ◽  
Paurene Duramad ◽  
Michael Jeng ◽  
Russell Scalf ◽  
...  
Keyword(s):  
Air Pollution ◽  
Information System ◽  
African American ◽  
Geographic Information System ◽  
Geographic Information ◽  
African American Children ◽  
American Children

scholarly journals Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction

Genetics ◽  
2020 ◽  
Vol 215 (3) ◽  
pp. 869-886
Author(s):  
Angel C. Y. Mak ◽  
Satria Sajuthi ◽  
Jaehyun Joo ◽  
Shujie Xiao ◽  
Patrick M. Sleiman ◽  
...  
Keyword(s):  
Air Pollution ◽  
African American ◽  
Lung Function ◽  
Genetic Association ◽  
Interaction Analysis ◽  
Whole Genome Sequencing Data ◽  
African American Children ◽  
Kit Ligand ◽  
Children With Asthma ◽  
American Children

Baseline lung function, quantified as forced expiratory volume in the first second of exhalation (FEV1), is a standard diagnostic criterion used by clinicians to identify and classify lung diseases. Using whole-genome sequencing data from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine project, we identified a novel genetic association with FEV1 on chromosome 12 in 867 African American children with asthma (P = 1.26 × 10−8, β = 0.302). Conditional analysis within 1 Mb of the tag signal (rs73429450) yielded one major and two other weaker independent signals within this peak. We explored statistical and functional evidence for all variants in linkage disequilibrium with the three independent signals and yielded nine variants as the most likely candidates responsible for the association with FEV1. Hi-C data and expression QTL analysis demonstrated that these variants physically interacted with KITLG (KIT ligand, also known as SCF), and their minor alleles were associated with increased expression of the KITLG gene in nasal epithelial cells. Gene-by-air-pollution interaction analysis found that the candidate variant rs58475486 interacted with past-year ambient sulfur dioxide exposure (P = 0.003, β = 0.32). This study identified a novel protective genetic association with FEV1, possibly mediated through KITLG, in African American children with asthma. This is the first study that has identified a genetic association between lung function and KITLG, which has established a role in orchestrating allergic inflammation in asthma.

Air Pollution and Asthma Exacerbations Among African-American Children in Los Angeles

1995 ◽  
Vol 7 (5) ◽  
pp. 711-722 ◽  
Author(s):  
Bart D. Ostro ◽  
Michael J. Lipsett ◽  
Jennifer K. Mann ◽  
Hazel Braxton-Owens ◽  
Mary C. White
Keyword(s):  
Air Pollution ◽  
African American ◽  
Los Angeles ◽  
African American Children ◽  
Asthma Exacerbations ◽  
American Children

Air Pollution and Exacerbation of Asthma in African-American Children in Los Angeles

Epidemiology ◽  
2001 ◽  
Vol 12 (2) ◽  
pp. 200-208 ◽  
Author(s):  
Bart Ostro ◽  
Michael Lipsett ◽  
Jennifer Mann ◽  
Hazel Braxton-Owens ◽  
and Mary White
Keyword(s):  
Air Pollution ◽  
African American ◽  
Los Angeles ◽  
African American Children ◽  
American Children

scholarly journals Analysis of Urban Air Pollution and The Effectiveness of Air Pollution Control Policy in Malaysia: Case Study in Klang Valley, Malaysia

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Siti Haslina Mohd Shafie ◽  
Suzani Mohamad ◽  
Nor Lita Fadilah Rameli ◽  
Sahala Benny Pasaribu
Keyword(s):  
Air Pollution ◽  
Information System ◽  
Air Quality ◽  
Geographic Information System ◽  
Environmental Sustainability ◽  
Local Community ◽  
Well Being ◽  
Geographic Information ◽  
Klang Valley ◽  
The Government

AbstractAir pollution in Malaysia is largely attributed to motor vehicles and land transportation, industrial activities and open burning. It has a hazardous effect on the public’s health and the environment. This study focuses on the spatial analysis of carbon monoxide (CO) and ozone (O3) concentrations trend in Klang Valley stations, specifically in Klang, Petaling Jaya, Kajang, Shah Alam and Cheras from 2000 to 2009. The study used the Inverse Distance Weighted (IDW) interpolation technique under the Geographic Information System (GIS). This study found that the distribution pattern of CO spatial concentrations in the Klang Valley is the highest concentration and reached 2.5 ppm, especially in Klang and Petaling Jaya stations in 2002 and 2003. However, the annual concentration of O3 recorded in Klang, Petaling Jaya, Kajang, Shah Alam, and Cheras stations from 2004 to 2009 is between 0.01 to 0.025 ppm. While air quality legislations have been introduced in Malaysia, policies and regulations being established by the government, their enforcement is still weak. Subsequently, air pollution is still a significant issue in Malaysia. Strong cooperation between the government, stakeholders and the local community is important to promote environmental sustainability and improve the community’s well-being. Keywords: Air pollution; Geographic Information System (GIS); Air Quality Policy; Malaysia

Geographic information system representing air pollution in an area

1992 ◽  
Vol 16 (4) ◽  
pp. 385-388
Author(s):  
Vladimir M. Borisov ◽  
Vladimir S. Tikunov ◽  
Sergej A. Gromov
Keyword(s):  
Air Pollution ◽  
Information System ◽  
Geographic Information System ◽  
Geographic Information

scholarly journals Distribution analysis of nitrogen dioxide (NO2) and ozone (O3) in Medan city with Geographic Information System (GIS)

2019 ◽  
Vol 276 ◽  
pp. 06013
Author(s):  
Isra Suryati ◽  
Hafizhul Khair ◽  
Deni Gusrianti
Keyword(s):  
Air Pollution ◽  
Information System ◽  
Geographic Information System ◽  
Nitrogen Dioxide ◽  
Urban Areas ◽  
Negative Impact ◽  
Geographic Information ◽  
Distribution Analysis ◽  
Air Pollution Control

The development of industry and the increase of transportation mode are directly proportional to the decrease in air quality. Some important pollutants have a negative impact on human health and the environment such as nitrogen dioxide (NO2) and ozone (O3). Distribution of NO2 and O3 concentrations from various sources of emissions in urban areas will provide basic information in the determination of policies, programs and regulations related to air pollution control. This study aims to map and analyze the concentration distribution of NO2 and O3 pollutants in Medan City. This research was conducted by a manual sampling of NO2 and O3 at 12 (twelve) points in Medan City. The sampling of NO2 and O3 concentrations is using impinger and then analyzed in a laboratory. The results showed that NO2 pollutant concentration in Medan City ranged from 21.33-306.19 |ig/m3. Meanwhile, for O3 concentrations ranged from 19.7-205.8 |ig/m3. Mapping of NO2 and O3 concentration using Geographic Information System obtained area that has the highest concentration of both NO2 and O3 is in Sub District of Medan Belawan. Furthermore, efforts to control air pollution can be done by applying clean technology to industry and encouraging the use of mass transportation.

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