scholarly journals Substorm dynamics in MHD: Statistical validation tests and paths for improvement

2021 ◽  
Author(s):  
John Haiducek ◽  
Daniel Welling ◽  
Steven Morley ◽  
Agnit Mukhopadhyay ◽  
Xiangning Chu ◽  
...  
Keyword(s):  
Statistical Validation ◽  
Validation Tests

The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

2018 ◽  
Vol 69 (7) ◽  
pp. 1830-1837
Author(s):  
Cristian Nicolescu ◽  
Alaxendru Pop ◽  
Alin Mihu ◽  
Luminita Pilat ◽  
Ovidiu Bedreag ◽  
...  
Keyword(s):  
Surgical Procedure ◽  
Tnf Alpha ◽  
Phase Reaction ◽  
Statistical Validation ◽  
Necrosis Factor Alpha ◽  
Surgical Interventions ◽  
Plasmatic Level ◽  
Factor Alpha ◽  
Validation Tests

This article presents an observational randomized prospective study done on 65 patients, who underwent major surgical interventions in the field of orthopedic surgery-total hip replacement or general surgery � total colectomy. The level of albuminemia in these cases were determined before the surgical intervention, after 6 hours of the intervention and after 24 h of the intervention. The measurements of the plasmatic concentration of the pro-inflammatory cytokines Tumor Necrosis factor -alpha (TNF-alpha) and interleukin 6 (IL6) were simultaneously done with the determination of the plasmatic levels of albumin. Values of hemoglobin and hematocrit were determined 24 h after the surgical procedure in order to exclude hemodilution, which could lead to a possible drop in the levels of plasmatic albumin. After the collection of the data, the statistical work was done and it consisted of descriptive statistics, correlation and comparison tests as well as statistical validation tests. Obtained results indicate that IL-6 plays a major role comparatively with that of TNF-alfa, regarding the decrease of the plasmatic level of albumin, and due to this, the primordial cause for hypoalbuminemia is an acute hepatic phase reaction. Supplemental permeability of the capillary wall under the action of TNF alpha has a secondary role, but could lead to a faster decrease in plasmatic albumin in the first hours after the surgical procedure.

scholarly journals Substorm dynamics in MHD: Statistical validation tests and paths for improvement

2021 ◽  
Author(s):  
John Haiducek ◽  
Daniel Welling ◽  
Steven Morley ◽  
Agnit Mukhopadhyay ◽  
Xiangning Chu ◽  
...  
Keyword(s):  
Statistical Validation ◽  
Validation Tests

A Bayesian View on the Hilbert Transform and the Kramers-Kronig Transform of Electrochemical Impedance Data: Probabilistic Estimates and Quality Scores

2020 ◽  
Author(s):  
Jiapeng Liu ◽  
Ting Hei Wan ◽  
Francesco Ciucci
Keyword(s):  
Power Generation ◽  
Electrochemical Impedance Spectroscopy ◽  
Hilbert Transform ◽  
Electrochemical Impedance ◽  
The Self ◽  
Impedance Data ◽  
The Hilbert Transform ◽  
Validation Tests ◽  
Self Consistency ◽  
Mathematical Relations

<p>Electrochemical impedance spectroscopy (EIS) is one of the most widely used experimental tools in electrochemistry and has applications ranging from energy storage and power generation to medicine. Considering the broad applicability of the EIS technique, it is critical to validate the EIS data against the Hilbert transform (HT) or, equivalently, the Kramers–Kronig relations. These mathematical relations allow one to assess the self-consistency of obtained spectra. However, the use of validation tests is still uncommon. In the present article, we aim at bridging this gap by reformulating the HT under a Bayesian framework. In particular, we developed the Bayesian Hilbert transform (BHT) method that interprets the HT probabilistic. Leveraging the BHT, we proposed several scores that provide quick metrics for the evaluation of the EIS data quality.<br></p>

The Development of a Turbidimetric Method for the Quantitative Determination of Antibiotics of the Aminoglycoside Group in Medications

2020 ◽  
Vol 65 (7-8) ◽  
pp. 37-41
Author(s):  
E. N. Semenova ◽  
S. I. Kuleshova ◽  
E. I. Sakanyan
Keyword(s):  
Quantitative Determination ◽  
Quality Assessment ◽  
Aminoglycoside Antibiotics ◽  
Metrological Characteristics ◽  
Streptomycin Sulfate ◽  
Turbidimetric Method ◽  
Validation Criteria ◽  
Validation Parameters ◽  
Validation Tests

A method for the quantitative determination of streptomycin sulfate in medicines by the turbidimetric method has been developedand validated. Based on the results of the experiments, it was found that the metrological characteristics of such validation parameters of the method as linearity, precision, and correctness do not exceed the validation criteria. Linearity was noted in the range of streptomycin concentrations from 3.75 to 8.43 μg/ml. The results of validation tests of the method for the quantitative determination of streptomycin indicate the prospects and feasibility of introducing the turbidimetric method into the domestic system for standardization and quality assessment of aminoglycoside antibiotics.

The effect of imperfect data on default prediction validation tests

2012 ◽  
Vol 6 (1) ◽  
pp. 77-96 ◽  
Author(s):  
Heather Russell ◽  
Douglas Dwyer ◽  
Qing Kang Tang
Keyword(s):  
Imperfect Data ◽  
Default Prediction ◽  
Validation Tests

pLoc_bal-mPlant: Predict Subcellular Localization of Plant Proteins by General PseAAC and Balancing Training Dataset

2019 ◽  
Vol 24 (34) ◽  
pp. 4013-4022 ◽  
Author(s):  
Xiang Cheng ◽  
Xuan Xiao ◽  
Kuo-Chen Chou
Keyword(s):  
Subcellular Localization ◽  
Basic Research ◽  
Training Dataset ◽  
Sequence Information ◽  
Plant Proteins ◽  
Protein Subcellular Localization ◽  
Computational Tools ◽  
Validation Tests ◽  
User Friendly ◽  
Better Than

Knowledge of protein subcellular localization is vitally important for both basic research and drug development. With the avalanche of protein sequences emerging in the post-genomic age, it is highly desired to develop computational tools for timely and effectively identifying their subcellular localization based on the sequence information alone. Recently, a predictor called “pLoc-mPlant” was developed for identifying the subcellular localization of plant proteins. Its performance is overwhelmingly better than that of the other predictors for the same purpose, particularly in dealing with multi-label systems in which some proteins, called “multiplex proteins”, may simultaneously occur in two or more subcellular locations. Although it is indeed a very powerful predictor, more efforts are definitely needed to further improve it. This is because pLoc-mPlant was trained by an extremely skewed dataset in which some subsets (i.e., the protein numbers for some subcellular locations) were more than 10 times larger than the others. Accordingly, it cannot avoid the biased consequence caused by such an uneven training dataset. To overcome such biased consequence, we have developed a new and bias-free predictor called pLoc_bal-mPlant by balancing the training dataset. Cross-validation tests on exactly the same experimentconfirmed dataset have indicated that the proposed new predictor is remarkably superior to pLoc-mPlant, the existing state-of-the-art predictor in identifying the subcellular localization of plant proteins. To maximize the convenience for the majority of experimental scientists, a user-friendly web-server for the new predictor has been established at http://www.jci-bioinfo.cn/pLoc_bal-mPlant/, by which users can easily get their desired results without the need to go through the detailed mathematics.

pLoc_bal-mEuk: Predict Subcellular Localization of Eukaryotic Proteins by General PseAAC and Quasi-balancing Training Dataset

2019 ◽  
Vol 15 (5) ◽  
pp. 472-485 ◽  
Author(s):  
Kuo-Chen Chou ◽  
Xiang Cheng ◽  
Xuan Xiao
Keyword(s):  
Drug Development ◽  
Subcellular Localization ◽  
Basic Research ◽  
The Other ◽  
Training Dataset ◽  
Sequence Information ◽  
Eukaryotic Proteins ◽  
Validation Tests ◽  
User Friendly ◽  
Better Than

<P>Background/Objective: Information of protein subcellular localization is crucially important for both basic research and drug development. With the explosive growth of protein sequences discovered in the post-genomic age, it is highly demanded to develop powerful bioinformatics tools for timely and effectively identifying their subcellular localization purely based on the sequence information alone. Recently, a predictor called “pLoc-mEuk” was developed for identifying the subcellular localization of eukaryotic proteins. Its performance is overwhelmingly better than that of the other predictors for the same purpose, particularly in dealing with multi-label systems where many proteins, called “multiplex proteins”, may simultaneously occur in two or more subcellular locations. Although it is indeed a very powerful predictor, more efforts are definitely needed to further improve it. This is because pLoc-mEuk was trained by an extremely skewed dataset where some subset was about 200 times the size of the other subsets. Accordingly, it cannot avoid the biased consequence caused by such an uneven training dataset. </P><P> Methods: To alleviate such bias, we have developed a new predictor called pLoc_bal-mEuk by quasi-balancing the training dataset. Cross-validation tests on exactly the same experimentconfirmed dataset have indicated that the proposed new predictor is remarkably superior to pLocmEuk, the existing state-of-the-art predictor in identifying the subcellular localization of eukaryotic proteins. It has not escaped our notice that the quasi-balancing treatment can also be used to deal with many other biological systems. </P><P> Results: To maximize the convenience for most experimental scientists, a user-friendly web-server for the new predictor has been established at http://www.jci-bioinfo.cn/pLoc_bal-mEuk/. </P><P> Conclusion: It is anticipated that the pLoc_bal-Euk predictor holds very high potential to become a useful high throughput tool in identifying the subcellular localization of eukaryotic proteins, particularly for finding multi-target drugs that is currently a very hot trend trend in drug development.</P>

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