Wood, due to its biological origin, has the capacity to interact with water. Sorption/desorption of moisture is accompanied with swelling/shrinkage and softening/hardening of its stiffness. The correct prediction of the behavior of wood components undergoing environmental loading or industrial process requires that the hygric, thermal and mechanical (HTM) behavior of wood are considered in a coupled manner. In addition, we propose a comprehensive framework using a fully coupled poromechanical approach, where its multiscale implementation provides the capacity to take into account, directly, the exact geometry of wood cellular structure, using computational homogenization. A hierarchical model is used to take into account the subcellular composite-like organization of the material. Such advanced modeling requires high resolution experimental data for the appropriate determination of inputs and for its validation.