Lopsided Blood‐Thinning Drug Increases the Risk of Internal Flow Choking Leading to Shock Wave Generation Causing Asymptomatic Cardiovascular Disease

Abstract P804: Lopsided Blood-Thinning Drug Increases the Risk of Internal Flow Choking and Shock Wave Generation Causing Asymptomatic Stroke

Stroke ◽

10.1161/str.52.suppl_1.p804 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Sanal Kumar V R ◽

Keyword(s):

Shock Wave ◽

In Silico ◽

Healthy Subjects ◽

Pressure Ratio ◽

Internal Flow ◽

Wave Generation ◽

Analytical Models ◽

Flow Choking ◽

Shock Wave Generation

Introduction: Consequence of lopsided blood-thinning-drug, lowering blood-viscosity (BV), is bleeding and very frequently asymptomatic-hemorrhage (AH) and the acute-heart-failure (AHF) happen. V.R.S.Kumar et al. (2020) reported that such asymptomatic episodes are due to the internal flow choking in the cardiovascular system (CVS) at a critical blood pressure ratio (BPR), which is regulated by biofluid/blood heat capacity ratio (BHCR). Methods: The closed-form-analytical-methodology is used for correlating BV, BPR, BHCR, vessel geometry and ejection fraction (EF). In vitro method is used for the BHCR estimation of healthy subjects. In silico method is used for demonstrating the Sanal flow choking. Results: The analytical models reveal that the relatively high and low BV are risk factors of internal flow choking. In vitro study shows that N 2 , O 2 , CO 2 & Ar gases are predominant in fresh-blood samples of the healthy subjects at a temperature range of 37-40 0 C (98.6-104 0 F), which increases the risk of flow-choking. In silico results demonstrated the Sanal flow choking followed by the shock wave generation and pressure-overshoot in a simulated artery with the divergent/bifurcation region. Conclusions: An overdose of blood-thinning drug reduces BV and increases Reynolds number causing high-turbulence leading to the Sanal flow choking. Asymptomatic stroke could be diminished by concurrently lessening the BV and flow turbulence by rising thermal tolerance level in terms of BHCR or by decreasing the BPR. In conclusion, BPR must always be lower than 1.8257 as dictated by the lowest BHCR of the evolved gas (CO 2 ) for prohibiting asymptomatic stroke.

Download Full-text

Lopsided Blood-thinning Drug Increases the Risk of Internal Flow Choking and Shock Wave Generation Causing Asymptomatic Stroke

10.31219/osf.io/pwkn8 ◽

2021 ◽

Author(s):

SANALKUMAR V R

Keyword(s):

Shock Wave ◽

In Silico ◽

Healthy Subjects ◽

Pressure Ratio ◽

Internal Flow ◽

Wave Generation ◽

Analytical Models ◽

Flow Choking ◽

Shock Wave Generation

Lopsided Blood-thinning Drug Increases the Risk of Internal Flow Choking and Shock Wave Generation Causing Asymptomatic Stroke Author Block: V R SANAL KUMAR, ISRO; S.K.Choudhary, AIIMS; P.K.Radhakrishnan, GU; Suresh Menon, GT; Vrishank Raghav, AU; K.K.N Namboodiri, Sapna E.Sreedharan, SCTIMST; Bharath R.S, Nichith C, C.Oommen, IISc; V.Sankar, IITK; A.Sukumaran, KCT; Arun K, DHMMC; A.Pal, Tharikaa R.K, AU, Abhirami R, AIMS. IntroductionConsequence of lopsided blood-thinning-drug, lowering blood-viscosity (BV), is bleeding and very frequently asymptomatic-hemorrhage (AH) and the acute-heart-failure (AHF) happen. V.R.S.Kumar et al. (2020) reported that such asymptomatic episodes are due to the internal flow choking in the cardiovascular system (CVS) at a critical blood-pressure-ratio (BPR), which is regulated by biofluid/blood heat capacity ratio (BHCR). MethodsThe closed-form-analytical-methodology is used for correlating BV, BPR, BHCR, vessel geometry and ejection fraction (EF). In vitro method is used for the BHCR estimation of healthy subjects. In silico method is used for demonstrating the Sanal flow choking. ResultsThe analytical models reveal that the relatively high and low BV are risk factors of internal flow choking. In vitro study shows that N2, O2, CO2 & Ar gases are predominant in fresh-blood samples of the healthy subjects at a temperature range of 37-400 C (98.6-1040 F), which increases the risk of flow-choking. In silico results demonstrated the Sanal flow choking followed by the shock wave generation and pressure-overshoot in a simulated artery with the divergent/bifurcation region. ConclusionsAn overdose of blood-thinning drug reduces BV and increases Reynolds number causing high-turbulence leading to the Sanal flow choking. Asymptomatic stroke could be diminished by concurrently lessening the BV and flow turbulence by rising thermal tolerance level in terms of BHCR or by decreasing the BPR. In conclusion, BPR must always be lower than 1.8257 as dictated by the lowest BHCR of the evolved gas for prohibiting asymptomatic stroke.

Download Full-text

Lopsided Blood-thinning Drug Increases the Risk of Internal Flow Choking and Shock Wave Generation Causing Asymptomatic Stroke

10.31219/osf.io/gky9s ◽

2021 ◽

Author(s):

SANALKUMAR V R

Keyword(s):

Shock Wave ◽

Thermal Tolerance ◽

Pressure Ratio ◽

Internal Flow ◽

Evolved Gas ◽

Flow Choking ◽

Tolerance Level ◽

Shock Wave Generation ◽

High Turbulence ◽

Flow Turbulence

An overdose of blood-thinning drug reduces blood viscosity (BV) and increases Reynolds number causing high-turbulence leading to the Sanal flow choking (PMCID: PMC7267099). Asymptomatic stroke could be diminished by concurrently lessening the BV and flow turbulence by rising thermal tolerance level in terms of biofluid/blood heat capacity ratio (BHCR) or by decreasing the blood pressure ratio (BPR). In conclusion, BPR must always be lower than 1.8257 as dictated by the lowest BHCR of the evolved gas (CO2) for prohibiting asymptomatic stroke.

Download Full-text

Internal Flow Choking in Cardiovascular System: A Radical Theory in the Risk Assessment of Asymptomatic Cardiovascular Diseases

10.5772/intechopen.96987 ◽

2021 ◽

Author(s):

Valsalayam Raghavapanicker Sanal Kumar ◽

Shiv Kumar Choudhary ◽

Pradeep Kumar Radhakrishnan ◽

Rajaghatta Sundararam Bharath ◽

Nichith Chandrasekaran ◽

...

Keyword(s):

Shock Wave ◽

Cardiovascular Risk ◽

Cardiovascular Diseases ◽

Cardiovascular System ◽

Blood Viscosity ◽

Wave Generation ◽

Flow Choking ◽

Shock Wave Generation

The theoretical discovery of Sanal flow choking in the cardiovascular system (CVS) demands for interdisciplinary studies and universal actions to propose modern medications and to discover new drugs to annul the risk of flow-choking leading to shock-wave generation causing asymptomatic-cardiovascular-diseases. In this chapter we show that when blood-pressure-ratio (BPR) reaches the lower-critical-hemorrhage-index (LCHI) the flow-choking could occur in the CVS with and without stent. The flow-choking is uniquely regulated by the biofluid/blood-heat-capacity-ratio (BHCR). The BHCR is well correlated with BPR, blood-viscosity and ejection-fraction. The closed-form analytical models reveal that the relatively high and the low blood-viscosity are cardiovascular-risk factors. In vitro data shows that nitrogen, oxygen, and carbon dioxide gases are predominant in fresh blood samples of the human being/Guinea-pig at a temperature range of 37–40 °C (98.6–104 °F). In silico results demonstrate the occurrence of Sanal flow choking leading to shock wave generation and pressure-overshoot in CVS without any apparent occlusion. We could conclude authoritatively, without any ex vivo or in vivo studies, that the Sanal flow choking in CVS leads to asymptomatic-cardiovascular-diseases. The cardiovascular-risk could be diminished by concurrently lessening the viscosity of biofluid/blood and flow-turbulence by increasing the thermal-tolerance level in terms of BHCR and/or by decreasing the BPR.

Download Full-text