Carotid intima-media thickness in late-onset major depressive disorder

BackgroundThere is evidence to suggest that cognitive deficits might persist beyond the acute stages of illness in major depressive disorder (MDD). However, the findings are somewhat inconsistent across the individual studies conducted to date. Our aim was to conduct a systematic review and meta-analysis of existing studies that have examined cognition in euthymic MDD patients.MethodFollowing a systematic search across several publication databases, meta-analyses were conducted for 27 empirical studies that compared euthymic adult MDD patients (895 participants) and healthy controls (997 participants) across a range of cognitive domains. The influence of demographic variables and confounding factors, including age of onset and recurrent episodes, was examined.ResultsCompared with healthy controls, euthymic MDD patients were characterized by significantly poorer cognitive functions. However, the magnitude of observed deficits, with the exception of inhibitory control, were generally modest when late-onset cases were excuded. Late-onset cases demonstrated significantly more pronounced deficits in verbal memory, speed of information processing and some executive functions.ConclusionsCognitive deficits, especially poor response inhibition, are likely to be persistent features, at least of some forms, of adult-onset MDD. More studies are necessary to examine cognitive dysfunction in remitted psychotic, melancholic and bipolar spectrum MDD. Cognitive deficits overall appear to be more common among patients with late-onset depression, supporting the theories suggesting that possible vascular and neurodegenerative factors play a role in a substantial number of these patients.

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Prevalence of major depressive disorder in self-referred patients in a late onset hypogonadism clinic

International Journal of Impotence Research ◽

10.1038/sj.ijir.3901551 ◽

2007 ◽

Vol 19 (4) ◽

pp. 407-410 ◽

Cited By ~ 14

Author(s):

Y Sato ◽

H Tanda ◽

S Kato ◽

S Onishi ◽

H Nakajima ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Late Onset ◽

Major Depressive ◽

Late Onset Hypogonadism

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Blood Transcriptomic Markers in Patients with Late-Onset Major Depressive Disorder

PLoS ONE ◽

10.1371/journal.pone.0150262 ◽

2016 ◽

Vol 11 (2) ◽

pp. e0150262 ◽

Cited By ~ 17

Author(s):

Shigeo Miyata ◽

Masashi Kurachi ◽

Yoshiko Okano ◽

Noriko Sakurai ◽

Ayumi Kobayashi ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Late Onset ◽

Major Depressive

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Brain Morphology Changes in a Remitted Patient With Late-Onset, Drug-Naïve, Non-Psychotic Major Depressive Disorder After Amisulpride Monotherapy

Journal of Neuropsychiatry ◽

10.1176/appi.neuropsych.12050130 ◽

2013 ◽

Vol 25 (2) ◽

pp. E59-E60 ◽

Cited By ~ 1

Author(s):

Yi-Cheng Hou ◽

Chien-Han Lai

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Late Onset ◽

Brain Morphology ◽

Major Depressive ◽

Drug Naïve ◽

Morphology Changes

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Structural Abnormality on Brain Magnetic Resonance Imaging in Late-onset Major Depressive Disorder

The Kaohsiung Journal of Medical Sciences ◽

10.1016/s1607-551x(09)70142-1 ◽

2005 ◽

Vol 21 (9) ◽

pp. 405-411 ◽

Cited By ~ 13

Author(s):

Hsiu-Fen Lin ◽

Yu-Ting Kuo ◽

I-Chan Chiang ◽

Hui-Mei Chen ◽

Cheng-Sheng Chen

Keyword(s):

Magnetic Resonance Imaging ◽

Major Depressive Disorder ◽

Magnetic Resonance ◽

Depressive Disorder ◽

Late Onset ◽

Brain Magnetic Resonance Imaging ◽

Structural Abnormality ◽

Resonance Imaging ◽

Major Depressive

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Factors Associated with the Risk of Developing Coronary Artery Disease in Medicated Patients with Major Depressive Disorder

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15102073 ◽

2018 ◽

Vol 15 (10) ◽

pp. 2073 ◽

Cited By ~ 16

Author(s):

Roger Ho ◽

Anna Chua ◽

Bach Tran ◽

Carol Choo ◽

Syeda Husain ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Interaction Effect ◽

Triglyceride Level ◽

Rating Scale ◽

Intima Media Thickness ◽

Mild Depression ◽

Major Depressive ◽

Factors Associated ◽

Framingham Risk

Background: The aim of this study was to identify factors associated with high Framingham Risk Score (FRS) in medicated patients with major depressive disorder (MDD). Methods: We examined 61 medicated patients with MDD (mean age 37.77 ± 7.67, 90.2% women) and 43 non-depressed controls (mean age 38.26 ± 9.20, 90.7% women). We administered the Hamilton Depression Rating Scale (HAM-D) and measured systolic blood pressure (SBP), diastolic BP (DBP), mean arterial BP (MAP), pulse wave velocity (PWV), intima-media thickness (IMT), interleukin-6 (IL-6) and triglycerides. Results: We found that medicated patients with MDD had significantly higher levels of HAM-D score (p < 0.01), SBP (p = 0.015), MAP (p = 0.037), IL−6 level (p = 0.007), as compared with controls. Medicated patients who remained moderately to severely depressed showed significantly higher SBP (p = 0.049), DBP (p = 0.009), MAP (p = 0.024), IL−6 level (p = 0.019), left PWV (p = 0.004) and average PWV (p = 0.026) than those with mild depression. Multivariate regression showed that the interaction effect between HAM-D score and triglyceride level (p = 0.018) was significantly associated with FRS in medicated patients with MDD. Conclusions: This study highlights that the interaction effect of the severity of depression and the triglyceride level, was a modifiable factor positively associated with high FRS.

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