Relationship between executive dysfunction and neuropsychiatric symptoms and impaired instrumental activities of daily living among patients with very mild Alzheimer's disease

2020 ◽  
Vol 35 (8) ◽  
pp. 877-887
Author(s):  
Hiroto Ikezaki ◽  
Mamoru Hashimoto ◽  
Tomohisa Ishikawa ◽  
Ryuji Fukuhara ◽  
Hibiki Tanaka ◽  
...  
2011 ◽  
Vol 5 (3) ◽  
pp. 153-166 ◽  
Author(s):  
Márcia L.F. Chaves ◽  
Claudia C. Godinho ◽  
Claudia S. Porto ◽  
Leticia Mansur ◽  
Maria Teresa Carthery-Goulart ◽  
...  

Abstract A review of the evidence on cognitive, functional and behavioral assessment for the diagnosis of dementia due to Alzheimer's disease (AD) is presented with revision and broadening of the recommendations on the use of tests and batteries in Brazil for the diagnosis of dementia due to AD. A systematic review of the literature (MEDLINE, LILACS and SCIELO database) was carried out by a panel of experts. Studies on the validation and/or adaptation of tests, scales and batteries for the Brazilian population were analyzed and classified according to level of evidence. There were sufficient data to recommend the IQCODE, DAFS-R, DAD, ADL-Q and Bayer scale for the evaluation of instrumental activities of daily living, and the Katz scale for the assessment of basic activities of daily living. For the evaluation of neuropsychiatric symptoms, the Neuropsychiatric Inventory (NPI) and the CAMDEX were found to be useful, as was the Cornell scale for depression in dementia. The Mini-Mental State Examination has clinical utility as a screening test, as do the multifunctional batteries (CAMCOG-R, ADAS-COG, CERAD and MDRS) for brief evaluations of several cognitive domains. There was sufficient evidence to recommend the CDR scale for clinical and severity assessment of dementia. Tests for Brazilian Portuguese are recommended by cognitive domain based on available data.


2013 ◽  
Vol 14 (2) ◽  
pp. 259-266 ◽  
Author(s):  
Carla Manuela Crispim Nascimento ◽  
Carlos Ayan ◽  
Jose Maria Cancela ◽  
Lilian Teresa Bucken Gobbi ◽  
Sebastião Gobbi ◽  
...  

2011 ◽  
Vol 7 (3) ◽  
pp. 300-308 ◽  
Author(s):  
Gad A. Marshall ◽  
Dorene M. Rentz ◽  
Meghan T. Frey ◽  
Joseph J. Locascio ◽  
Keith A. Johnson ◽  
...  

2021 ◽  
Author(s):  
Vívian Maria Gomes de Oliveira ◽  
Cíntia Gonçalves Nogueira ◽  
Gabriela Ferreira Paticcié ◽  
Leonardo Oliveira Silva ◽  
Igor Jacomedes de Oliveira ◽  
...  

Background: Alzheimer’s disease (AD) represents one of the main causes of cognitive and functional decline in the world. Concomitant with pharmacological treatment, the practice of aerobic exercises (AE) can help in the symptomatic control of the disease. Objectives: To evaluate the effects of AE on activities of daily living and cognition in patients with AD. Methods: A systematic review was undertaken. EMBASE, Pubmed and BVS databases were searched using the terms “Alzheimer disease”, “Alzheimer syndrome” and “Alzheimer dementia”; “aerobic” and “exercise”. The inclusion criteria were: randomized controlled trials from 2016 to 2021, English language studies and human studies. Among 854 studies found, six were included in the review. Results: The potential benefits of AE training in AD patients are: improvement of functioning, quality of life and cognitive performance; better control of neuropsychiatric symptoms and possible reduction of systemic inflammation. Conclusions: AEs are associated with cognitive and functional performance gain in AD, probably related to synaptic plasticity optimization and improvement of the feeling of well-being. Although AEs may improve cognitive and neuropsychiatric symptoms, the response to treatment is individual. Future longitudinal studies with larger cohorts and functional neuroimaging studies are required for a better understanding of the real benefit of AE in AD.


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