scholarly journals Different structural correlates for verbal memory impairment in temporal lobe epilepsy with and without mesial temporal lobe sclerosis

2011 ◽  
Vol 33 (2) ◽  
pp. 489-499 ◽  
Author(s):  
Susanne G. Mueller ◽  
Kenneth D. Laxer ◽  
Cathy Scanlon ◽  
Paul Garcia ◽  
William J. McMullen ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Verbal Memory ◽  
Memory Impairment ◽  
Mesial Temporal Lobe

scholarly journals Multiple hippocampal transections for mesial temporal lobe epilepsy

2021 ◽  
Vol 12 ◽  
pp. 372
Author(s):  
David Pitskhelauri ◽  
Elina Kudieva ◽  
Maria Kamenetskaya ◽  
Antonina Kozlova ◽  
Pavel Vlasov ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Verbal Memory ◽  
Visual Memory ◽  
Focal Cortical Dysplasia ◽  
Mesial Temporal Lobe Epilepsy ◽  
Drug Resistant ◽  
Preoperative Level ◽  
Temporal Pole ◽  
Mesial Temporal Lobe

Background: The purpose of this study was to evaluate the effectiveness of multiple hippocampal transections (MHT) in the treatment of drug-resistant mesial temporal lobe epilepsy. Methods: Six patients underwent MHT at Burdenko Neurosurgery Center in 2018. The age of the patients varied from 18 to 43 years. All patients suffered from refractory epilepsy caused by focal lesions of the mesial temporal complex or temporal pole in dominant side. Postoperative pathology revealed neuronal-glial tumors in two patients, focal cortical dysplasia (FCD) of the temporal pole – in two patients, cavernous angioma – in one patient, and encephalocele of the preuncal area – in one patient. Results: All patients underwent surgery satisfactorily. There were no postoperative complications except for homonymous superior quadrantanopia. This kind of visual field loss was noted in four cases out of six. During the follow-up period five patients out of six had Engel Class I outcome (83.3%). In one case, seizures developed after 1 month in a patient with FCD in the uncus (Engel IVA). After surgery, three out of six patients developed significant nominative aphasia. Two patients relative to the preoperative level demonstrated improvement in delayed verbal memory after MHT. Two patients showed a decrease level in delayed verbal memory. In preoperative period, visual memory was below the normal in one patient. Delayed visual memory in two cases impaired compared to the preoperative level. Conclusion: MHT can be considered as an effective method of drug-resistant mesial temporal lobe epilepsy caused by tumors of the medial temporal complex. At the same time, MHT makes it possible to preserve memory in patients with structurally preserved hippocampus. However, MHT do not guarantee the preservation of memory after surgery.

Transsylvian hippocampal transection for mesial temporal lobe epilepsy: surgical indications, procedure, and postoperative seizure and memory outcomes

2013 ◽  
Vol 119 (5) ◽  
pp. 1098-1104 ◽  
Author(s):  
Takehiro Uda ◽  
Michiharu Morino ◽  
Hirotaka Ito ◽  
Noriaki Minami ◽  
Atsushi Hosono ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Verbal Memory ◽  
Memory Function ◽  
Mesial Temporal Lobe Epilepsy ◽  
Hippocampal Atrophy ◽  
Delayed Recall ◽  
Nonverbal Memory ◽  
Mesial Temporal Lobe ◽  
The Right

Object Amygdalohippocampectomy is a well-established, standard surgery for medically intractable mesial temporal lobe epilepsy (MTLE). However, in the case of MTLE without hippocampal atrophy or sclerosis, amygdalohippocampectomy is associated with decreased postoperative memory function. Hippocampal transection (HT) has been developed to overcome this problem. In HT the hippocampus is not removed; rather, the longitudinal hippocampal circuits of epileptic activities are disrupted by transection of the pyramidal layer of the hippocampus. The present study describes a less invasive modification of HT (transsylvian HT) and presents the seizure and memory outcomes for this procedure. Methods Thirty-seven patients with MTLE (18 men and 19 women; age range 9–63 years; 19 with surgery on the right side and 18 with surgery on the left side; seizure onset from 3 to 34 years) who were treated with transsylvian HT were retrospectively analyzed. All patients had left-side language dominance, and follow-up periods ranged from 12 to 94 months (median 49 months). Seizure outcomes were evaluated for all patients by using the Engel classification. Memory function was evaluated for 22 patients based on 3 indices (verbal memory, nonverbal memory, and delayed recall), with those scores obtained using the Wechsler Memory Scale–Revised. Patients underwent evaluation of the memory function before and after surgery (6 months–1 year). Results Engel Class I (completely seizure free) was achieved in 25 patients (67.6%). Class II and Class III designation was achieved in 10 (27%) and 2 patients (5.4%), respectively. There were differences in memory outcome between the sides of operation. On the right side, verbal memory significantly increased postoperatively (p = 0.003) but nonverbal memory and delayed recall showed no significant change after the operation (p = 0.718 and p = 0.210, respectively). On the left side, all 3 indices (verbal memory, nonverbal memory, and delayed recall) showed no significant change (p = 0.331, p = 0.458, and p = 0.366, respectively). Conclusions Favorable seizure outcome and preservation of verbal memory were achieved with transsylvian HT for the treatment of MTLE without hippocampal atrophy or sclerosis.

Biomagnetic profiles of verbal memory success in patients with mesial temporal lobe epilepsy

2009 ◽  
Vol 16 (3) ◽  
pp. 527-533 ◽  
Author(s):  
F. Maestú ◽  
P. Campo ◽  
I. García-Morales ◽  
A. del Barrio ◽  
N. Paul ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Verbal Memory ◽  
Mesial Temporal Lobe Epilepsy ◽  
Mesial Temporal Lobe

Impact of hippocampal subfield histopathology in episodic memory impairment in mesial temporal lobe epilepsy and hippocampal sclerosis

2017 ◽  
Vol 75 ◽  
pp. 183-189 ◽  
Author(s):  
Sandra Mara Comper ◽  
Anaclara Prada Jardim ◽  
Jeana Torres Corso ◽  
Larissa Botelho Gaça ◽  
Maria Helena Silva Noffs ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Memory Impairment ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Mesial Temporal Lobe

scholarly journals Clinical utility of structural connectomics in predicting memory in temporal lobe epilepsy

Neurology ◽  
2020 ◽  
Vol 94 (23) ◽  
pp. e2424-e2435 ◽  
Author(s):  
Akshara R. Balachandra ◽  
Erik Kaestner ◽  
Naeim Bahrami ◽  
Anny Reyes ◽  
Sanam Lalani ◽  
...  
Keyword(s):  
White Matter ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Verbal Memory ◽  
Memory Impairment ◽  
Memory Performance ◽  
Principal Component ◽  
Hippocampal Volume ◽  
Clinical Model ◽  
Clinical Variables

ObjectiveTo determine the predictive power of white matter neuronal networks (i.e., structural connectomes [SCs]) in discriminating memory-impaired patients with temporal lobe epilepsy (TLE) from those with normal memory.MethodsT1- and diffusion MRI (dMRI), clinical variables, and neuropsychological measures of verbal memory were available for 81 patients with TLE. Prediction of memory impairment was performed with a tree-based classifier (XGBoost) for 4 models: (1) a clinical model including demographic and clinical features, (2) a hippocampal volume (HCV) model, (3) a tract model including 5 temporal lobe white matter association tracts derived from a dMRI atlas, and (4) an SC model based on dMRI. SCs were derived by extracting cortical-cortical connections from a temporal lobe subnetwork with probabilistic tractography. Principal component (PC) analysis was then applied to reduce the dimensionality of the SC, yielding 10 PCs. Multimodal models were also tested combining SCs and tracts with HCV. Each model was trained on 48 patients from 1 epilepsy center and tested on 33 patients from a different center.ResultsMultimodal models that included the SC + HCV model yielded the highest classification accuracy (81%; 0.90 sensitivity; 0.67 specificity), outperforming the clinical model (61%; p < 0.001) and HCV model (66%; p < 0.001). In addition, the unimodal SC model (76% accuracy) and tract model (73% accuracy) outperformed the clinical model (p < 0.001) and HCV model (p < 0.001) for classifying patients with TLE with and without memory impairment. Furthermore, the SC identified that short-range temporal-temporal connections were important contributors to memory performance.ConclusionSCs and tract-based models are stronger predictors of memory impairment in TLE than HCVs and clinical variables. However, SCs may provide additional information about local cortical-cortical connectivity contributing to memory that is not captured in large association tracts.

scholarly journals Memory impairment is not necessarily related to seizure frequency in mesial temporal lobe epilepsy with hippocampal sclerosis

Epilepsia ◽  
2014 ◽  
Vol 55 (8) ◽  
pp. 1197-1204 ◽  
Author(s):  
Denise Pacagnella ◽  
Tatila M. Lopes ◽  
Marcia E. Morita ◽  
Clarissa L. Yasuda ◽  
Fabio A. M. Cappabianco ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Seizure Frequency ◽  
Memory Impairment ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Mesial Temporal Lobe

scholarly journals Postoperative Neuropsychological Outcome in Patients with Mesial Temporal Lobe Epilepsy in Argentina

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Silvia Oddo ◽  
Patricia Solis ◽  
Damian Consalvo ◽  
Eduardo Seoane ◽  
Brenda Giagante ◽  
...  
Keyword(s):  
Executive Function ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Verbal Memory ◽  
Visual Memory ◽  
Mesial Temporal Lobe Epilepsy ◽  
Memory Deficit ◽  
Temporal Lobectomy ◽  
Neuropsychological Outcome ◽  
Mesial Temporal Lobe

The aim of the present study is to compare pre- and postsurgical neuropsychological outcome in individuals suffering from mesial temporal lobe epilepsy (mTLE), in order to evaluate prognosis. The selected thirty-five patients had medically mTLE and had undergone an anterior temporal lobectomy (ATL). Neuropsychological evaluation was performed in three different stages: before ATL, 6 months after resection, and a year afterwards. Neuropsychological protocol evaluated attention, verbal memory, visual memory, executive function, language, intelligence, and handedness. There was a significant improvement () in the group with visual memory deficit after surgery, whereas no changes were observed across patients with verbal memory deficit. No changes were observed in language after surgery. Executive function showed significant improvement 6 months after surgery (). Postoperative outcome of cognitive impairments depends on baseline neuropsychological status of the patients with TLE. In our case series, deficits found in patients with mTLE after ATL did not result in a subjective complaint.

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