Elective neck dissection in early-stage oral squamous cell carcinoma—does it influence recurrence and survival?

Head & Neck ◽  
2006 ◽  
Vol 29 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Ana Capote ◽  
Veronica Escorial ◽  
Mario F. Muñoz-Guerra ◽  
Francisco J. Rodríguez-Campo ◽  
Carlos Gamallo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Early Stage ◽  
Elective Neck Dissection

scholarly journals Elective neck dissection improves the survival of patients with T2N0M0 oral squamous cell carcinoma: a study of the SEER database

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alimujiang Wushou ◽  
Feiluore Yibulayin ◽  
Lu Sheng ◽  
Yuan Luo ◽  
Zhi-cheng Yang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Early Stage ◽  
The United States ◽  
Elective Neck Dissection ◽  
Rank Test ◽  
Observation Group

Abstract Background Treatment of clinical N0 neck tumours is controversial in early-stage oral squamous cell carcinoma (OSCC), possibly because T1N0M0 and T2N0M0 merge together at early stages. The purposes of this study were to compare survival outcomes only for T2N0M0 cases based upon treatment elective neck dissection versus neck observation. Methods T2N0M0 OSCC cases were identified in the Surveillance, Epidemiology, and End Results database of the United States National Cancer Institute between 2004 and 2015. Survival curves for different variable values were generated using Kaplan-Meier estimates and compared using the log-rank test. Variables that achieved significance at P < 0.05 were entered into multivariable analyses via the Cox proportional hazards multivariate regression. Results A total of 2857 patients were selected, and 2313 cases were available for disease specific survival (DSS). The 5-year and 10-year overall survival (OS) were 66.7 and 46% for patients receiving elective neck dissection (END), respectively, and 56.4 and 37.2% for patients with neck observation (P < 0.0001). The 5-year and 10-year DSS were 73.6 and 64% for the END group, respectively, versus 64.5 and 54.5% for the neck observation group (P < 0.0001). More importantly, performing END was independently associated with favourable DSS and OS for patients with T2N0M0 OSCC [hazard ratio (HR) = 0.769, P = 0.0069 for DSS; HR = 0.829, P = 0.0031 for OS, neck observation group as reference] according to multivariate survival analysis. Conclusion END is recommended for T2N0M0 OSCC cases and it is associated with improved DSS and OS.

Elective neck dissection in early-stage oral squamous cell carcinoma

Head & Neck ◽  
2008 ◽  
Vol 30 (2) ◽  
pp. 274-275
Author(s):  
Ana Capote-Moreno ◽  
Mario F. Muñoz-Guerra
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Early Stage ◽  
Elective Neck Dissection

scholarly journals Patients With cT1N0M0 Oral Squamous Cell Carcinoma Benefit From Elective Neck Dissection: A SEER-Based Study

2021 ◽  
Vol 19 (4) ◽  
pp. 385-392
Author(s):  
Alimujiang Wushou ◽  
Meng Wang ◽  
Feiluore Yibulayin ◽  
Lei Feng ◽  
Meng-meng Lu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Early Stage ◽  
Tumor Resection ◽  
Elective Neck Dissection ◽  
Disease Specific Survival ◽  
Disease Specific

Background: The incidence of oral squamous cell carcinoma (OSCC) is increasing, with an estimated 369,000 new patients each year worldwide. Surgery is the primary treatment modality for early-stage OSCC, but there is scant evidence to prove the value of elective neck dissection (END) for relatively small early-stage OSCC. This study aimed to identify factors predicting survival for patients with clinical stage T1N0M0 (cT1N0M0) OSCC and whether up-front END improved survival. Patients and Methods: Patients with cT1N0M0 OSCC who underwent tumor resection with or without END were identified and extracted from the SEER database. Kaplan-Meier survival analysis was used to assess overall survival and disease-specific survival. Prognostic factors were determined using Cox regression analysis. Results: A total of 5,752 patients with cT1N0M0 OSCC were extracted, of whom 2,194 (38.1%) underwent tumor resection surgery with concurrent END and 3,558 (61.9%) underwent only tumor resection. In a multivariate Cox analysis, a relatively advanced age (>62 years) and relatively high pathologic grade were the significant negative predictors, but married status (hazard ratio, 0.709; P=.006) and undergoing END (hazard ratio, 0.708; P<.001) were identified as significant independent positive factors. Conclusions: Patients with cT1N0M0 OSCC gain significant overall and disease-specific survival benefit from END.

Improved survival with elective neck dissection in thick early-stage oral squamous cell carcinoma

Head & Neck ◽  
2011 ◽  
Vol 34 (5) ◽  
pp. 709-716 ◽  
Author(s):  
Ardalan Ebrahimi ◽  
Bruce G. Ashford ◽  
Jonathan R. Clark
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Early Stage ◽  
Elective Neck Dissection

Elective neck dissection in early-stage oral squamous cell carcinoma

Head & Neck ◽  
2008 ◽  
Vol 30 (2) ◽  
pp. 273-274
Author(s):  
Zoukaa B. Sargi ◽  
Elizabeth J. Franzmann
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Early Stage ◽  
Elective Neck Dissection
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