Focal adhesion kinase overexpression: Correlation with lymph node metastasis and shorter survival in oral squamous cell carcinoma

Head & Neck ◽  
2012 ◽  
Vol 35 (6) ◽  
pp. 826-830 ◽  
Author(s):  
Juan Carlos de Vicente ◽  
Pablo Rosado ◽  
Paloma Lequerica-Fernández ◽  
Eva Allonca ◽  
Lucas Villallaín ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Squamous Cell ◽  
Node Metastasis

scholarly journals Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma

2018 ◽  
Vol 38 (11) ◽  
pp. 6157-6162 ◽  
Author(s):  
SATOMI ARIMOTO ◽  
TAKUMI HASEGAWA ◽  
DAISUKE TAKEDA ◽  
IZUMI SAITO ◽  
RIKA AMANO ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Node Metastasis

SOX4 expression is closely associated with differentiation and lymph node metastasis in oral squamous cell carcinoma

2013 ◽  
Vol 47 (3) ◽  
pp. 150-155 ◽  
Author(s):  
Masahiro Watanabe ◽  
Yuichi Ohnishi ◽  
Masahiro Wato ◽  
Akio Tanaka ◽  
Kenji Kakudo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Node Metastasis

Development and validation of a multivariable prediction model for the identification of occult lymph node metastasis in oral squamous cell carcinoma

Head & Neck ◽  
2020 ◽  
Vol 42 (8) ◽  
pp. 1811-1820 ◽  
Author(s):  
Maxime Mermod ◽  
Eva‐Francesca Jourdan ◽  
Ruta Gupta ◽  
Massimo Bongiovanni ◽  
Genrich Tolstonog ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Prediction Model ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Node Metastasis ◽  
Development And Validation ◽  
Occult Lymph Node Metastasis

Prediction of lymph node metastasis in oral squamous cell carcinoma based on protein profile

2019 ◽  
Vol 16 (4) ◽  
pp. 363-373
Author(s):  
Binbin Yu ◽  
Wei Cao ◽  
Chenping Zhang ◽  
Ronghui Xia ◽  
Jinlin Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Protein Profile ◽  
Node Metastasis

scholarly journals Role and Mechanism of LIF in Oral Squamous Cell Carcinoma Progression

2020 ◽  
Vol 9 (2) ◽  
pp. 295 ◽  
Author(s):  
Ting-An Lin ◽  
Tai-Sheng Wu ◽  
Yue-Ju Li ◽  
Cheng-Ning Yang ◽  
Monica Maria Illescas Ralda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Advanced Cancer ◽  
Squamous Cell ◽  
Severe Problem ◽  
Node Metastasis ◽  
Downstream Effector

Background: Metastasis is a severe problem in patients with oral squamous cell carcinoma (OSCC), which is the fifth most common cancer worldwide. Leukemia inhibitory factor (LIF) has been studied in different cancers, while the role of LIF in OSCC remains unclear. Methods: LIF expression was detected in 100 OSCC samples by immunohistochemistry. Effects of LIF on cell motility were evaluated in OSCC cell lines. High-throughput microarray analysis was also conducted. The correlation between LIF and the downstream effector was analyzed by real-time quantitative reverse transcription PCR. Results: Patients with OSCC who had lymph node metastasis or advanced cancer stages showed high LIF expression. OSCC patients with higher LIF expression, advanced stage, large tumor size, or lymph node metastasis had significantly shorter overall survival. LIF regulated cancer cell motilities through outside-in signaling. The inhibin beta A subunit (INHBA) gene was identified as a crucial downstream effector of LIF-promoted OSCC progression and restored migration and invasion abilities in LIF knockdown transfectants. Conclusion: LIF enhances regional lymphatic spread, thus leading to an advanced cancer stage. Regulation of LIF downstream molecules such as INHBA inhibits the invasion or migration ability of cancer cells. Thus, LIF can be a potential target in preventing cancer metastasis and spread.

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