Three prognostic indexes as predictors of response to adjuvant chemoradiotherapy in patients with oral squamous cell carcinoma after radical surgery: A large‐scale prospective study

Head & Neck ◽  
2018 ◽  
Author(s):  
Fa Chen ◽  
Lisong Lin ◽  
Fengqiong Liu ◽  
Lingjun Yan ◽  
Yu Qiu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Prospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Large Scale ◽  
Radical Surgery ◽  
Adjuvant Chemoradiotherapy ◽  
Predictors Of Response ◽  
Prognostic Indexes

Squamous cell carcinoma of the posterior urethra: Outcomes following radical surgery and adjuvant chemo-radiotherapy.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 425-425
Author(s):  
Fabio Castiglione ◽  
Michelle Christodoulidou ◽  
Raj Nigam ◽  
Peter Malone ◽  
Anita Mitra ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radical Prostatectomy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radical Surgery ◽  
Neoadjuvant Chemoradiotherapy ◽  
Adjuvant Chemoradiotherapy ◽  
Bladder Preservation ◽  
Treatment Protocols ◽  
Posterior Urethra

425 Background: Squamous cell carcinoma (SCC) of the posterior urethra is rare and is associated with sexually transmitted infections, urethritis, chronic strictures or urethral surgery. Unlike anterior urethral SCC, the presentation of posterior urethral SCC is often late and there are currently no standardised treatment protocols. We present our series of posterior urethral SCC treated by radical surgery and bladder preservation by performing a pan-urethrectomy, radical prostatectomy with a bladder neck closure and chemoradiotherapy. Methods: We retrospectively collected data from patients diagnosed with posterior urethral SCC from a penile cancer database. Data including patient age, histological subtypes, surgical management, post-operative complications, chemo-radiotherapy and survival rates were recorded. Results: A total of 10 cases with histologically proven posterior urethral SCC were treated in a single centre. Median follow-up was 19 months (SD±10 months). Mean age at presentation was 49 years (SD±6.44) and usual type SCC (80%) was the most prevalent histological subtype followed by NOS and condylomatous SCC. The majority of cases were poorly differentiated SCC (70%), stage ≥ T3 and required radical surgery with total urethrectomy and radical prostatectomy. Complications included post-operative ileus (30%), wound infection (20%), sepsis (10%), perioperative transfusion was required in one patient. Lymphovascular invasion was present in 90% of cases and local recurrence occurred in 60% of patients. Only one patient was suitable for neo-adjuvant chemo-radiotherapy (cisplatin/5-FU) and a further 5 required adjuvant chemoradiotherapy following surgery. 60% of patients developed metastatic disease and 60% died with a median survival of 9.6 months (SD±5.3) from diagnosis to death. Conclusions: Posterior urethral SCC is rare and the late presentation means that neoadjuvant chemoradiotherapy is often not possible. Radical surgery requires a pan-urethrectomy and urinary diversion. Despite adjuvant chemoradiotherapy, posterior urethral SCC is associated with significant mortality with a median survivial of less than one year.

The role of clinical versus histopathological staging in patients with advanced oral squamous cell carcinoma treated with neoadjuvant radiochemotherapy followed by radical surgery

2013 ◽  
Vol 41 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Matthias Kreppel ◽  
Timo Dreiseidler ◽  
Daniel Rothamel ◽  
Hans-Theodor Eich ◽  
Uta Drebber ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radical Surgery ◽  
Neoadjuvant Radiochemotherapy

scholarly journals Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 292-301
Author(s):  
Yong-Xin Cui ◽  
Xian-Shuang Su
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Oral Squamous Cell Carcinoma ◽  
Programmed Cell Death ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Large Scale ◽  
Meta Analysis ◽  
Human Papilloma Virus Infection ◽  
Clinicopathological Features

AbstractObjectiveProgrammed cell death-ligand 1 (PD-L1) expression has been shown to play important roles in various types of cancer. However, the role of PD-L1 expression has not been conclusively reported in patients with oral squamous cell carcinoma (OSCC). Accordingly, in this meta-analysis, we investigated the clinicopathological value of PD-L1 expression in patients with OSCC.MethodsGoogle Scholar, PubMed, EMBASE, and CNKI databases were searched to find relevant studies published through to September 16, 2019. The relationships between PD-L1 expression in patients with OSCC and clinicopathological features were assessed using risk ratio (RR) and 95% confidence intervals (CIs).ResultsSixteen studies including 1989 participants were included. The results indicated that high PD-L1 expression was correlated with sex (RR = 1.28, 95% CI: 1.16–1.42, P < 0.001), N stage (RR = 1.19, 95% CI: 1.06–1.33, P = 0.003), M stage (RR = 1.64, 95% CI: 1.01–2.66, P = 0.044), low differentiation (RR = 1.16, 95% CI: 1.01–1.33, P = 0.034), and human papilloma virus infection (RR = 1.38, 95% CI: 1.14–1.68, P = 0.001), but unrelated to TNM stage or T stage. There was no significant publication bias in the studies included in this analysis.ConclusionsThis meta-analysis revealed that high PD-L1 expression in patients with OSCC was correlated with clinicopathological features. Further large-scale studies are necessary to confirm our results.

The prognostic relevance of lymph node ratio in patients with oral squamous cell carcinoma treated with neoadjuvant therapy regimen and radical surgery

2018 ◽  
Vol 46 (9) ◽  
pp. 1659-1663 ◽  
Author(s):  
V. Rempel ◽  
A.F. Safi ◽  
U. Drebber ◽  
H.J. Nickenig ◽  
J. Neugebauer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neoadjuvant Therapy ◽  
Squamous Cell ◽  
Lymph Node Ratio ◽  
Radical Surgery ◽  
Therapy Regimen ◽  
Node Ratio

O164. A prospective study of surgical margin status in oral squamous cell carcinoma (OSCC)

2009 ◽  
Vol 3 (1) ◽  
pp. 110
Author(s):  
Y. Ran ◽  
M. Vered ◽  
S. Teicher ◽  
Y.P. Talmi ◽  
L. Bedrin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Prospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margin ◽  
Margin Status ◽  
A Prospective Study
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