Reproductive factors and thyroid cancer risk: Meta‐analysis

Head & Neck ◽  
2019 ◽  
Vol 41 (12) ◽  
pp. 4199-4208
Author(s):  
Arathy S. Mannathazhathu ◽  
Preethi S. George ◽  
Sreekala Sudhakaran ◽  
Durga Vasudevan ◽  
Jagathnath Krishna KM ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Reproductive Factors ◽  
Thyroid Cancer Risk

scholarly journals Reproductive Factors but Not Hormonal Factors Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yijuan Cao ◽  
Zengyan Wang ◽  
Juan Gu ◽  
Fangfang Hu ◽  
Yujuan Qi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Breast Feeding ◽  
Meta Analysis ◽  
Reproductive Factors ◽  
Epidemiological Studies ◽  
Older Age ◽  
Hormonal Factors ◽  
Age At Menopause ◽  
Thyroid Cancer Risk

Many studies have investigated the association between hormonal and reproductive factors and thyroid cancer risk but provided contradictory and inconclusive findings. This review was aimed at precisely estimating this association by pooling all available epidemiological studies. 25 independent studies were retrieved after a comprehensive literature search in databases of PubMed and Embase. Overall, common hormonal factors including oral contraceptive and hormone replacement therapy did not alter the risk of thyroid cancer. Older age at menopause was associated with weakly increased risk of thyroid cancer in overall analysis (RR = 1.24, 95% CI 1.00–1.53,P=0.049); however, longer duration of breast feeding was related to moderately reduced risk of thyroid cancer, suggested by pooled analysis in all cohort studies (RR = 0.7, 95% CI 0.51–0.95,P=0.021). The pooled RR in hospital-based case-control studies implicated that parous women were more susceptible to thyroid cancer than nulliparous women (RR = 2.30, 95% CI 1.31–4.04,P=0.004). The present meta-analysis suggests that older age at menopause and parity are risk factors for thyroid cancer, while longer duration of breast feeding plays a protective role against this cancer. Nevertheless, more relevant epidemiological studies are warranted to investigate roles of hormonal and reproductive factors in thyroid carcinogenesis.

scholarly journals An overall and dose-response meta-analysis for thyrotropin and thyroid cancer risk by histological type

Oncotarget ◽  
2016 ◽  
Vol 7 (30) ◽  
pp. 47750-47759 ◽  
Author(s):  
Na Hu ◽  
Zhan-Ming Li ◽  
Jin-Feng Liu ◽  
Zhen-Zhen Zhang ◽  
Li-Shun Wang
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Histological Type ◽  
Thyroid Cancer Risk

scholarly journals Parity and thyroid cancer risk: a meta‐analysis of epidemiological studies

2015 ◽  
Vol 5 (4) ◽  
pp. 739-752 ◽  
Author(s):  
Jingjing Zhu ◽  
Xiao Zhu ◽  
Chao Tu ◽  
Yuan‐Yuan Li ◽  
Ke‐Qing Qian ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Thyroid Cancer Risk

Thyroid cancer risk and smoking status: a meta-analysis

2014 ◽  
Vol 25 (9) ◽  
pp. 1187-1195 ◽  
Author(s):  
Young Ae Cho ◽  
Jeongseon Kim
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Smoking Status ◽  
Meta Analysis ◽  
Thyroid Cancer Risk

scholarly journals Breastfeeding and thyroid cancer risk in women: A dose-response meta-analysis of epidemiological studies

2016 ◽  
Vol 35 (5) ◽  
pp. 1039-1046 ◽  
Author(s):  
Xingyang Yi ◽  
Jingjing Zhu ◽  
Xiao Zhu ◽  
Guang Jian Liu ◽  
Lang Wu
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Thyroid Cancer Risk

scholarly journals Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

2021 ◽  
Author(s):  
Yayun Wu ◽  
Yun Ren ◽  
Zhimin Cao ◽  
Kai Zhang ◽  
Xiaoqiang Dong ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Recessive Model ◽  
Single Nucleotide ◽  
Knowledge Infrastructure ◽  
Xrcc3 Gene ◽  
Thyroid Cancer Risk ◽  
Chinese National Knowledge Infrastructure

Abstract Objective To explore the association between single nucleotide polymorphism (SNP) in the XRCC3 rs861539(Thr241Met) locus and thyroid cancer risk. Methods Studies investigating the association between SNP in the XRCC3 gene and thyroid cancer susceptibility were retrieved from the PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), WanFang, and CBM (China Biology Medicine) databases. Eligible studies were screened according to inclusion/exclusion criteria and principles of quality evaluation. Meta-analysis was performed using Stata 14.0 software. Odds ratios with their corresponding 95% confidence intervals were pooled to assess the association between SNP in the XRCC3 gene rs861539 locus and thyroid cancer susceptibility. Results 10 articles(11 studies) were eligible for this meta-analysis. Meta-analysis results were shown as follows: No significant association was found between XRCC3 rs861539 polymorphism and thyroid cancer risk in Dominant and Overdominant models〔Dominant model: CT+TT vs CC, OR=1.231, 95% CI(0.998, 1.474); Overdominant model: CT vs TT+CC, OR=1.05, 95% CI(0.94, 1.18)〕. Significant associations were found in Recessive and Allelic models〔Recessive model: TT vs CC+CT, OR=1.632, 95% CI(1.349, 1.974); Allelic model: T vs C: OR=1.263, 95% CI(1.091, 1.462)〕. Conclusion The results of this study suggest that the XRCC3 rs861539(Thr241Met) polymorphism may be associated with an increased thyroid cancer risk in overall population, and a tendency for significantly increased thyroid cancer risk in TT(Met/Met) genotype population.

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