Durability of the parotid‐sparing effect of intensity‐modulated radiotherapy ( IMRT ) in early stage nasopharyngeal carcinoma: A 15‐year follow‐up of a randomized prospective study of IMRT versus two‐dimensional radiotherapy

Head & Neck ◽  
2021 ◽  
Author(s):  
Darren M. C. Poon ◽  
Michael K. M. Kam ◽  
David Johnson ◽  
Frankie Mo ◽  
Macy Tong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Prospective Study ◽  
Early Stage ◽  
Intensity Modulated Radiotherapy ◽  
Two Dimensional ◽  
Intensity Modulated ◽  
Parotid Sparing ◽  
Sparing Effect

scholarly journals Comparison of the efficacy between intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in stage II nasopharyngeal carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 78096-78104 ◽  
Author(s):  
Xin-Bin Pan ◽  
Kai-Hua Chen ◽  
Shi-Ting Huang ◽  
Yan-Ming Jiang ◽  
Jia-Lin Ma ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Stage Ii ◽  
Two Dimensional ◽  
Conventional Radiotherapy ◽  
Intensity Modulated

scholarly journals Effect of intensity-modulated radiotherapy versus two-dimensional conventional radiotherapy alone in nasopharyngeal carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (22) ◽  
pp. 33408-33417 ◽  
Author(s):  
Pu-Yun OuYang ◽  
Dingbo Shi ◽  
Rui Sun ◽  
Yu-Jia Zhu ◽  
Yao Xiao ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Two Dimensional ◽  
Conventional Radiotherapy ◽  
Intensity Modulated ◽  
Radiotherapy Alone

scholarly journals Radiation-Induced Temporal Lobe Injury for Nasopharyngeal Carcinoma: A Comparison of Intensity-Modulated Radiotherapy and Conventional Two-Dimensional Radiotherapy

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67488 ◽  
Author(s):  
Guan-Qun Zhou ◽  
Xiao-Li Yu ◽  
Mo Chen ◽  
Rui Guo ◽  
Ying Lei ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Temporal Lobe ◽  
Intensity Modulated Radiotherapy ◽  
Two Dimensional ◽  
Intensity Modulated ◽  
Radiation Induced

Treatment outcomes of 257 patients with locally advanced nasopharyngeal carcinoma treated with nimotuzumab plus intensity-modulated radiotherapy with or without chemotherapy: A single institution experience.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 6079-6079
Author(s):  
Wang Fang Zheng ◽  
Chuner Jiang
Keyword(s):  
Multivariate Analysis ◽  
Nasopharyngeal Carcinoma ◽  
Clinical Stage ◽  
Late Complication ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Stage Iv ◽  
Long Term Outcome ◽  
Intensity Modulated

6079 Background: To report the long-term outcome and toxicitie of locally advanced nasopharyngeal carcinoma (NPC) treated with nimotuzumab plus intensity- modulated radiotherapy (IMRT) with or without chemotherapy. Methods: From October 2009 to March 2014, 257 newly histology-proven, non-metastatic NPC patients were retrospectively enrolled. They are aged 10-76 years. The distribution of disease was stage III in 150 (58.4%), stage IV A in 88 (34.2%), and stage IV B in 19 (7.4%). All the patients received the treatment of nimotuzumab plus IMRT, and 239 cases were used for cisplatin-based chemotherapy. Acute and late radiation-related toxicities were graded according to the Acute and Late Radiation Morbidity Scoring Criteria of Radiation Therapy Oncology Group. The accumulated survival was calculated according to the Kaplan-Meier method. Log-rank test was used to compare the survival difference. Multivariate analysis was performed using Cox’s proportional hazard model. Results: All patients had completed the combined treatment. With a median follow-up of 48 months (range, 13–94 months), the estimated 3-year and 5-year overall survival rates were 92.6% and 86.2%, respectively. Univariate analysis showed that age, T stage, clinical stage and neoadjvant chemotherapy were related with OS. Multivariate analysis indicated that age and clinical stage were independent prognosticators. The median cycle for nimotuzumab addition was 12 weeks. The incidence of grade 3–4 acute mucositis and leukocytopenia were 10.9% and 9.3%, respectively, with no cases of skin rash and infusion reaction. Xerostomia was the most common late complication, and the degree of dry mouth in most survivors was mild-to-moderate at the last follow-up time. Conclusions: Nimotuzumab plus IMRT with or without chemotherapy showed promising outcomes in terms of loco-regional control and survival, without increasing the incidence of radiation-related toxicities for patients.

A prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients

2012 ◽  
Vol 104 (3) ◽  
pp. 317-323 ◽  
Author(s):  
Harry C.Y. Cheng ◽  
Vincent W.C. Wu ◽  
Roger K.C. Ngan ◽  
K.W. Tang ◽  
Charlie C.L. Chan ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Prospective Study ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated ◽  
A Prospective Study

scholarly journals Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma

Cancer ◽  
2004 ◽  
Vol 101 (7) ◽  
pp. 1584-1593 ◽  
Author(s):  
Dora L. W. Kwong ◽  
Edmond H. N. Pow ◽  
Jonathan S. T. Sham ◽  
Anne S. McMillan ◽  
Lucullus H. T. Leung ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Early Stage ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated
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