Intensity-modulated radiotherapy prolongs the survival of patients with nasopharyngeal carcinoma compared with conventional two-dimensional radiotherapy: A 10-year experience with a large cohort and long follow-up

2015 ◽  
Vol 51 (17) ◽  
pp. 2587-2595 ◽  
Author(s):  
Meng-Xia Zhang ◽  
Jing Li ◽  
Guo-Ping Shen ◽  
Xiong Zou ◽  
Jun-Jie Xu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Large Cohort ◽  
Two Dimensional ◽  
Intensity Modulated

scholarly journals Comparison of the efficacy between intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in stage II nasopharyngeal carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 78096-78104 ◽  
Author(s):  
Xin-Bin Pan ◽  
Kai-Hua Chen ◽  
Shi-Ting Huang ◽  
Yan-Ming Jiang ◽  
Jia-Lin Ma ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Stage Ii ◽  
Two Dimensional ◽  
Conventional Radiotherapy ◽  
Intensity Modulated

scholarly journals Effect of intensity-modulated radiotherapy versus two-dimensional conventional radiotherapy alone in nasopharyngeal carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (22) ◽  
pp. 33408-33417 ◽  
Author(s):  
Pu-Yun OuYang ◽  
Dingbo Shi ◽  
Rui Sun ◽  
Yu-Jia Zhu ◽  
Yao Xiao ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Two Dimensional ◽  
Conventional Radiotherapy ◽  
Intensity Modulated ◽  
Radiotherapy Alone

scholarly journals Radiation-Induced Temporal Lobe Injury for Nasopharyngeal Carcinoma: A Comparison of Intensity-Modulated Radiotherapy and Conventional Two-Dimensional Radiotherapy

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67488 ◽  
Author(s):  
Guan-Qun Zhou ◽  
Xiao-Li Yu ◽  
Mo Chen ◽  
Rui Guo ◽  
Ying Lei ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Temporal Lobe ◽  
Intensity Modulated Radiotherapy ◽  
Two Dimensional ◽  
Intensity Modulated ◽  
Radiation Induced

Treatment outcomes of 257 patients with locally advanced nasopharyngeal carcinoma treated with nimotuzumab plus intensity-modulated radiotherapy with or without chemotherapy: A single institution experience.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 6079-6079
Author(s):  
Wang Fang Zheng ◽  
Chuner Jiang
Keyword(s):  
Multivariate Analysis ◽  
Nasopharyngeal Carcinoma ◽  
Clinical Stage ◽  
Late Complication ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Stage Iv ◽  
Long Term Outcome ◽  
Intensity Modulated

6079 Background: To report the long-term outcome and toxicitie of locally advanced nasopharyngeal carcinoma (NPC) treated with nimotuzumab plus intensity- modulated radiotherapy (IMRT) with or without chemotherapy. Methods: From October 2009 to March 2014, 257 newly histology-proven, non-metastatic NPC patients were retrospectively enrolled. They are aged 10-76 years. The distribution of disease was stage III in 150 (58.4%), stage IV A in 88 (34.2%), and stage IV B in 19 (7.4%). All the patients received the treatment of nimotuzumab plus IMRT, and 239 cases were used for cisplatin-based chemotherapy. Acute and late radiation-related toxicities were graded according to the Acute and Late Radiation Morbidity Scoring Criteria of Radiation Therapy Oncology Group. The accumulated survival was calculated according to the Kaplan-Meier method. Log-rank test was used to compare the survival difference. Multivariate analysis was performed using Cox’s proportional hazard model. Results: All patients had completed the combined treatment. With a median follow-up of 48 months (range, 13–94 months), the estimated 3-year and 5-year overall survival rates were 92.6% and 86.2%, respectively. Univariate analysis showed that age, T stage, clinical stage and neoadjvant chemotherapy were related with OS. Multivariate analysis indicated that age and clinical stage were independent prognosticators. The median cycle for nimotuzumab addition was 12 weeks. The incidence of grade 3–4 acute mucositis and leukocytopenia were 10.9% and 9.3%, respectively, with no cases of skin rash and infusion reaction. Xerostomia was the most common late complication, and the degree of dry mouth in most survivors was mild-to-moderate at the last follow-up time. Conclusions: Nimotuzumab plus IMRT with or without chemotherapy showed promising outcomes in terms of loco-regional control and survival, without increasing the incidence of radiation-related toxicities for patients.

scholarly journals Intensity-modulated radiotherapy provides better quality of life than two-dimensional conventional radiotherapy for patients with stage II nasopharyngeal carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (28) ◽  
pp. 46211-46218 ◽  
Author(s):  
Xin-Bin Pan ◽  
Shi-Ting Huang ◽  
Kai-Hua Chen ◽  
Yan-Ming Jiang ◽  
Jia-Lin Ma ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Stage Ii ◽  
Two Dimensional ◽  
Conventional Radiotherapy ◽  
Intensity Modulated

scholarly journals Individualized Clinical Target Volume Delineation and Efficacy Analysis in Unilateral Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy (IMRT): 10-Year Summary and Results

2021 ◽  
Author(s):  
De-Huan Xie ◽  
Zheng Wu ◽  
Wang-Zhong Li ◽  
Wan-Qin Cheng ◽  
Ya-Lan Tao ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Clinical Target Volume ◽  
Parapharyngeal Space ◽  
Intensity Modulated Radiotherapy ◽  
Target Volume ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Intensity Modulated

Abstract Purpose: To evaluate the long-term local control, failure patterns, and toxicities after individualized clinical target volume (CTV) delineation in unilateral nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT).Methods: Unilateral NPC was defined as nasopharyngeal mass confined to one side of nasopharynx and did not significantly exceed the midline of nasopharyngeal apex/posterior wall. From November 2003 to December 2017, 95 patients with long-term follow-up were retrospectively included. All patients received IMRT. The CTVs were determined based on the distance from the gross tumor, the contralateral parapharyngeal space and skull base orifices were spared from irradiation.Results: There were 3 local recurrence and 8 regional recurrences in 10 patients during 84- month follow-up. All local recurrences were PGTVnx-in-field, and no recurrences in traditional high-risk area including contralateral parapharyngeal space and skull base orifices. The 10-year local-recurrence free survival, regional-recurrence free survival and overall survival were 96.2%, 90.5% and 84.7%, respectively. The dosimetry parameters of the tumor-contralateral organs were all lower than the values of the tumor-ipsilateral side (P < 0.05). The late toxicities occurred mainly in the tumor-ipsilateral organs, including radiation-induced temporal lobe injury, impaired visuality, hearing loss and subcutaneous fibrosis.Conclusion: Individualized CTV delineation in unilateral NPC could yield excellent long-term local control with limited out-of-field recurrences, reduced dose to tumor- contralateral organs and mild late toxicities, which is worthy of further exploration.

scholarly journals Xerostomia, salivary characteristics and gland volumes following intensity-modulated radiotherapy for nasopharyngeal carcinoma: a two-year follow up

2018 ◽  
Vol 63 (2) ◽  
pp. 217-223 ◽  
Author(s):  
CPC Sim ◽  
YL Soong ◽  
EPP Pang ◽  
C Lim ◽  
GD Walker ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated
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