An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: Implications for hemostasis and clinical outcome

Hepatology ◽  
2013 ◽  
Vol 58 (2) ◽  
pp. 752-761 ◽  
Author(s):  
Greg C. G. Hugenholtz ◽  
Jelle Adelmeijer ◽  
Joost C. M. Meijers ◽  
Robert J. Porte ◽  
R. Todd Stravitz ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Von Willebrand Factor ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure

2016 ◽  
Vol 35 (6) ◽  
pp. 432-440 ◽  
Author(s):  
K. S. Prasanna ◽  
Ashish Goel ◽  
G. Jayakumar Amirtharaj ◽  
Anup Ramachandran ◽  
K. A. Balasubramanian ◽  
...  
Keyword(s):  
Liver Failure ◽  
Von Willebrand Factor ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Hospital Survival ◽  
Von Willebrand ◽  
Willebrand Factor

Von Willebrand factor could be an index of endothelial dysfunction in patients with cirrhosis: relationship to degree of liver failure and nitric oxide levels

1999 ◽  
Vol 30 (3) ◽  
pp. 451-455 ◽  
Author(s):  
Liliana Albornoz ◽  
Daniel Alvarez ◽  
Juan Carlos Otaso ◽  
Adrián Gadano ◽  
Julieta Salviú ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Liver Failure ◽  
Von Willebrand Factor ◽  
Von Willebrand ◽  
Willebrand Factor

Plasma von Willebrand Factor Levels Correlate with Clinical Outcome of Severe Traumatic Brain Injury

2007 ◽  
Vol 24 (8) ◽  
pp. 1331-1338 ◽  
Author(s):  
Clarissa Oliveira De Oliveira ◽  
Alexandre Gard Reimer ◽  
Adriana Brondani Da Rocha ◽  
Ivana Grivicich ◽  
Rogério Fett Schneider ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Outcome ◽  
Von Willebrand Factor ◽  
Severe Traumatic Brain Injury ◽  
Von Willebrand ◽  
Willebrand Factor

Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension

Gut ◽  
2011 ◽  
Vol 60 (8) ◽  
pp. 1133-1138 ◽  
Author(s):  
V. La Mura ◽  
J. C. Reverter ◽  
A. Flores-Arroyo ◽  
S. Raffa ◽  
E. Reverter ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Clinical Outcome ◽  
Von Willebrand Factor ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Targeting Raised von Willebrand Factor Levels in Liver Diseases: Opening Up Newer Therapeutic Avenues

2020 ◽  
Keyword(s):  
Liver Failure ◽  
Von Willebrand Factor ◽  
Liver Diseases ◽  
Therapeutic Potential ◽  
Chronic Liver Failure ◽  
Microcirculatory Perfusion ◽  
Coagulation Protein ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Opening Up

Raised levels of the blood coagulation protein von Willebrand factor (VWF) are now recognised to be important in patients with liver disease. The markedly raised plasma VWF levels in patients with acute liver failure and acute-on-chronic liver failure may contribute to the pathogenesis of liver failure, and of multi-organ failure, by impeding microcirculatory perfusion in the liver and the other affected vital organs. In this review, the authors present a brief introduction to VWF biology, discuss the ability of raised plasma VWF levels to accurately predict survival in different syndromes of liver diseases, speculate why plasma VWF levels are raised in liver failure syndromes, and examine the therapeutic potential of VWF-lowering therapies in these scenarios.

Sign in / Sign up

Export Citation Format

Share Document