scholarly journals Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine

Hepatology ◽  
2018 ◽  
Vol 68 (3) ◽  
pp. 848-858 ◽  
Author(s):  
Nao Nishida ◽  
Masaya Sugiyama ◽  
Hiromi Sawai ◽  
Sohji Nishina ◽  
Aiko Sakai ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Vaccine

scholarly journals Circulating Tfh cell and subsets distribution are associated with low‐responsiveness to hepatitis B vaccination

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Mingjuan Yin ◽  
Yongzhen Xiong ◽  
Dongmei Liang ◽  
Hao Tang ◽  
Qian Hong ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Vaccine ◽  
Hepatitis B Vaccination ◽  
Cellular Mechanisms ◽  
Immunological Responses ◽  
Follicular Helper ◽  
Low Responders ◽  
Specific Subset ◽  
Antibody Titers

Abstract Background An estimated 5–10 % of healthy vaccinees lack adequate antibody response following receipt of a standard three-dose hepatitis B vaccination regimen. The cellular mechanisms responsible for poor immunological responses to hepatitis B vaccine have not been fully elucidated to date. Methods There were 61 low responders and 56 hyper responders involved in our study. Peripheral blood samples were mainly collected at D7, D14 and D28 after revaccinated with a further dose of 20 µg of recombinant hepatitis B vaccine. Results We found low responders to the hepatitis B vaccine presented lower frequencies of circulating follicular helper T (cTfh) cells, plasmablasts and a profound skewing away from cTfh2 and cTfh17 cells both toward cTfh1 cells. Importantly, the skewing of Tfh cell subsets correlated with IL-21 and protective antibody titers. Based on the key role of microRNAs involved in Tfh cell differentiation, we revealed miR-19b-1 and miR-92a-1 correlated with the cTfh cell subsets distribution and antibody production. Conclusions Our findings highlighted a decrease in cTfh cells and specific subset skewing contribute to reduced antibody responses in low responders.

scholarly journals The role of hepatitis B vaccine challenge dose in patients with underlying health conditions

2020 ◽  
pp. 1-5 ◽  
Author(s):  
L. Sticchi ◽  
I. G. Iavarone ◽  
P. Durando ◽  
A. Di Biagio ◽  
I. Schiavetti ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Vaccine ◽  
Health Conditions ◽  
Challenge Dose

Role of T-regulatory cells in the response to hepatitis B vaccine in hemodialysis patients

2015 ◽  
Vol 20 (2) ◽  
pp. 242-252 ◽  
Author(s):  
Roy O. Mathew ◽  
Darius L. Mason ◽  
Renjie Song ◽  
Tiffany Tryniszewski ◽  
Jeffrey S. Kennedy
Keyword(s):  
Hepatitis B ◽  
T Regulatory Cells ◽  
Hemodialysis Patients ◽  
Hepatitis B Vaccine ◽  
Regulatory Cells

scholarly journals Impact of vaccination in the reduction of hepatitis B in Paraná

2014 ◽  
Vol 35 (1) ◽  
pp. 78-86 ◽  
Author(s):  
Priscila PUDELCO ◽  
Andreia Eloize KOEHLER ◽  
Lúcia Helena Linheira BISETTO
Keyword(s):  
Hepatitis B ◽  
Quantitative Research ◽  
Vaccine Coverage ◽  
Sexual Transmission ◽  
Secondary Data ◽  
Hepatitis B Vaccine ◽  
Hepatitis B Vaccination ◽  
Role Of Nursing ◽  
The Impact

This study identified the impact of hepatitis B vaccine over reducing incidence of this disease in Paraná State, between 2001 and 2011, and discussed the role of nursing in immunization. Descriptive documental and quantitative research. Utilized secondary data of hepatitis B, between 2001 and 2011 and vaccination coverage of hepatitis B vaccine between 1995 and 2011 in Paraná State, available in DATASUS, SINAN and Immunization Programs. Data has been collected from May to July 2012. Included cases of hepatitis B confirmed by laboratory testing. Of the 14,434 selected cases, 81,8% was in urban residents, 86,5% belonged to 20 to 59 age group and 45,3% were infected by sexual transmission. In the correlation of vaccine coverage with the incidence, was identified reducing this rate in the range of 0 to 9 years old, in places with vaccination coverage's above 95%. It concludes that hepatitis B vaccination had impact over disease reduction in Paraná State.

Analysis Refutes Hepatitis B Vaccine, RA Link

2007 ◽  
Vol 41 (9) ◽  
pp. 14
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Vaccine

Ensuring Newborns Receive Hepatitis B Vaccine

2012 ◽  
Vol 46 (2) ◽  
pp. 10
Author(s):  
CHRISTOPHER J. HARRISON
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Vaccine
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