scholarly journals Assessment of Adenosine Triphosphatase Phospholipid Transporting 8B1 (ATP8B1) Function in Patients With Cholestasis With ATP8B1 Deficiency by Using Peripheral Blood Monocyte‐Derived Macrophages

2020 ◽  
Author(s):  
Ayumu Mizutani ◽  
Yusuke Sabu ◽  
Sotaro Naoi ◽  
Shogo Ito ◽  
Satoshi Nakano ◽  
...  
Diabetes ◽  
2012 ◽  
Vol 61 (5) ◽  
pp. 1281-1290 ◽  
Author(s):  
Katharine M. Irvine ◽  
Patricia Gallego ◽  
Xiaoyu An ◽  
Shannon E. Best ◽  
Gethin Thomas ◽  
...  

Blood ◽  
1999 ◽  
Vol 93 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Katsuaki Sato ◽  
Hiroshi Kawasaki ◽  
Hitomi Nagayama ◽  
Ryo Serizawa ◽  
Junji Ikeda ◽  
...  

Abstract We examined the potential involvement of two CC chemokine receptors (CCRs), CCR-1 and CCR-3, in the functional activation of granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin-4 (IL-4)–generated human peripheral blood monocyte-derived immature dendritic cells (DCs). Flow cytometric analysis showed that CCR-1, CCR-3, CCR-5, and CXC chemokine receptor (CXCR)-4 were expressed on the cell surface of monocyte-derived DCs. Treatment with a monoclonal antibody (MoAb) to either CCR-1 or CCR-3 but not MoAbs to CCR-5 and CXCR-4 abolished chemotactic migration of monocyte-derived DCs. The DCs treated with either the anti–CCR-1 MoAb or anti–CCR-3 MoAb were less efficient than untreated DCs in proliferation of allogeneic T cells (TCs) and TC-derived secretion of interferon-γ (IFN-γ). The homotypic aggregation of DCs and heterotypic aggregation of DCs with TCs were suppressed by the anti–CCR-1 MoAb or anti–CCR-3 MoAb. These results indicate that CCR-1 and CCR-3 specifically regulate interaction of TCs and DCs in the process of antigen presentation.


Pancreatology ◽  
2019 ◽  
Vol 19 (8) ◽  
pp. 1043-1048 ◽  
Author(s):  
Jaime de la Fuente ◽  
Ayush Sharma ◽  
Suresh Chari ◽  
Shounak Majumder

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