Policy considerations for scaling up access to HIV pre‐exposure prophylaxis for adolescent girls and young women: Examples from Kenya, South Africa, and Uganda

2021 ◽  
Author(s):  
Jeff Lane ◽  
Audrey Brezak ◽  
Pragna Patel ◽  
Andre R. Verani ◽  
Irene Benech ◽  
...  
Keyword(s):  
South Africa ◽  
Adolescent Girls ◽  
Young Women ◽  
Scaling Up ◽  
Exposure Prophylaxis

scholarly journals The Community PrEP Study: a randomized control trial leveraging community-based platforms to improve access and adherence to pre-exposure prophylaxis to prevent HIV among adolescent girls and young women in South Africa—study protocol

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Andrew Medina-Marino ◽  
Dana Bezuidenhout ◽  
Sybil Hosek ◽  
Ruanne V. Barnabas ◽  
Millicent Atujuna ◽  
...  
Keyword(s):  
South Africa ◽  
Adolescent Girls ◽  
Young Women ◽  
Randomized Control Trial ◽  
Community Based ◽  
Adherence Support ◽  
Randomized Control ◽  
Exposure Prophylaxis ◽  
Effective Use ◽  
Improve Access

Abstract Background HIV incidence among South African adolescent girls and young women (AGYW) remains high, but could be reduced by highly effective pre-exposure prophylaxis (PrEP). Unfortunately, AGYW report significant barriers to clinic-based sexual and reproductive health services. Even when AGYW access PrEP as an HIV prevention method, poor prevention-effective use was a serious barrier to achieving its optimal HIV prevention benefits. Determining the acceptability and feasibility of community-based platforms to increase AGYW’s access to PrEP, and evaluating behavioural interventions to improve prevention-effective use of PrEP are needed. Methods We propose a mixed-methods study among AGYW aged 16–25 years in Eastern Cape Province, South Africa. In the first component, a cross-sectional study will assess the acceptability and feasibility of leveraging community-based HIV counselling and testing (CBCT) platforms to refer HIV-negative, at-risk AGYW to non-clinic-based, same-day PrEP initiation services. In the second component, we will enrol 480 AGYW initiating PrEP via our CBCT platforms into a three-armed (1:1:1) randomized control trial (RCT) that will evaluate the effectiveness of adherence support interventions to improve the prevention-effective use of PrEP. Adherence will be measured over 24 months via tenofovir-diphosphate blood concentration levels. Qualitative investigations will explore participant, staff, and community experiences associated with community-based PrEP services, adherence support activities, study implementation, and community awareness. Costs and scalability of service platforms and interventions will be evaluated. Discussion This will be the first study to assess the acceptability and feasibility of leveraging CBCT platforms to identify and refer at-risk AGYW to community-based, same-day PrEP initiation services. It will also provide quantitative and qualitative results to inform adherence support activities and services that promote the prevention-effective use of PrEP among AGYW. By applying principles of implementation science, behavioural science, and health economics research, we aim to inform strategies to improve access to and prevention-effective use of PrEP by AGYW. Trial registration ClinicalTrials.govNCT03977181. Registered on 6 June 2019—retrospectively registered.

The Effect of PrEP Use Disclosure on Adherence in a Cohort of Adolescent Girls and Young Women in South Africa

2021 ◽  
Author(s):  
Danielle Giovenco ◽  
Audrey Pettifor ◽  
Kimberly A. Powers ◽  
Lisa Hightow-Weidman ◽  
Brian W. Pence ◽  
...  
Keyword(s):  
South Africa ◽  
Adolescent Girls ◽  
Young Women

scholarly journals Persistently high incidence of HIV and poor service uptake in adolescent girls and young women in rural KwaZulu-Natal, South Africa prior to DREAMS

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0203193 ◽  
Author(s):  
Natsayi Chimbindi ◽  
Nondumiso Mthiyane ◽  
Isolde Birdthistle ◽  
Sian Floyd ◽  
Nuala McGrath ◽  
...  
Keyword(s):  
South Africa ◽  
Adolescent Girls ◽  
Young Women ◽  
Kwazulu Natal ◽  
High Incidence

scholarly journals Exposure and predictors of intention to use HIV pre-exposure prophylaxis (PrEP) among adolescent girls and young women: assessment of Jipende JiPrEP campaign in Kisumu, Kenya

2021 ◽  
Vol 4 ◽  
Author(s):  
Sarah Hawi ◽  
Dickens Omondi Aduda ◽  
Charles Ongadi Nyambuga ◽  
Patience Aoko Oduor ◽  
Hellen Aoko Awuoche ◽  
...  
Keyword(s):  
Adolescent Girls ◽  
Young Women ◽  
Intention To Use ◽  
Exposure Prophylaxis

Community Space, Community Groups, and Incident HIV Infection Among Adolescent Girls and Young Women in Rural South Africa

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Nivedita L. Bhushan ◽  
Marie C.D. Stoner ◽  
Rhian Twine ◽  
Kathleen Kahn ◽  
Sheri A. Lippman ◽  
...  
Keyword(s):  
South Africa ◽  
Hiv Infection ◽  
Adolescent Girls ◽  
Young Women ◽  
Community Groups ◽  
Rural South ◽  
Community Space ◽  
Rural South Africa

scholarly journals Standardised patient encounters to improve quality of counselling for pre-exposure prophylaxis (PrEP) in adolescent girls and young women (AGYW) in Kenya: study protocol of a cluster randomised controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e035689
Author(s):  
Anna Larsen ◽  
Kate S Wilson ◽  
John Kinuthia ◽  
G John-Stewart ◽  
BA Richardson ◽  
...  
Keyword(s):  
High Risk ◽  
Communication Skills ◽  
Adolescent Girls ◽  
Young Women ◽  
Training Intervention ◽  
Improve Quality ◽  
Cluster Randomised ◽  
Exposure Prophylaxis ◽  
Standardised Patient

IntroductionAdolescent girls and young women (AGYW) in sub-Saharan Africa are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) demonstration projects observe that AGYW uptake and adherence to PrEP during risk periods is suboptimal. Judgemental interactions with healthcare workers (HCW) and inadequate counselling can be barriers to PrEP use among AGYW. Improving HCW competency and communication to support PrEP delivery to AGYW requires new strategies.Methods and analysisPrEP Implementation for Young Women and Adolescents Program-standardised patient (PrIYA-SP) is a cluster randomised trial of a standardised patient actor (SP) training intervention designed to improve HCW adherence to PrEP guidelines and communication skills. We purposively selected 24 clinics offering PrEP services under fully programmatic conditions in Kisumu County, Kenya. At baseline, unannounced SP ‘mystery shoppers’ present to clinics portraying AGYW in common PrEP scenarios for a cross-sectional assessment of PrEP delivery. Twelve facilities will be randomised to receive a 2-day training intervention, consisting of lectures, role-playing with SPs and group debriefing. Unannounced SPs will repeat the assessment in all 24 sites following the intervention. The primary outcome is quality of PrEP counselling, including adherence to national guidelines and communication skills, scored on a checklist by SPs blinded to intervention assignment. An intention-to-treat (ITT) analysis will evaluate whether the intervention resulted in higher scores within intervention compared with control facilities, adjusted for baseline SP scores and accounting for clustering by facility. We hypothesise that the intervention will improve quality of PrEP counselling compared with standard of care. Results from this study will inform guidelines for PrEP delivery to AGYW in low-resource settings and offer a potentially scalable strategy to improve service delivery for this high-risk group.Ethics and disseminationThe protocol was approved by institutional review boards at Kenyatta National Hospital and University of Washington. An external advisory committee monitors social harms. Results will be disseminated through peer-reviewed journals and presentations.Trial registration numberNCT03875950

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