scholarly journals Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head-and-neck cancer xenografts

2002 ◽  
Vol 99 (3) ◽  
pp. 396-402 ◽  
Author(s):  
Iris Verel ◽  
Karl-Heinz Heider ◽  
Miranda Siegmund ◽  
El�nborg Ostermann ◽  
Erik Patzelt ◽  
...  
2017 ◽  
Author(s):  
Hsuan-Chen Liu ◽  
Falguni Parikh ◽  
Thomas Kraus ◽  
Thomas Moran ◽  
Andrew Sikora

1985 ◽  
Vol 241 (3) ◽  
pp. 225-232
Author(s):  
Eduard C. M. Heinerman ◽  
Boudewijn J. M. Braakhuis ◽  
Gijs H. Boerrigter ◽  
Gordon B. Snow

2006 ◽  
Vol 6 (8) ◽  
pp. 691-710 ◽  
Author(s):  
Igor Astsaturov ◽  
Roger Cohen ◽  
Paul Harari

2011 ◽  
Vol 2 (2) ◽  
pp. 87-94
Author(s):  
Stanislas Blein ◽  
Sam Hou

ABSTRACT Over the past two decades, monoclonal antibodies have emerged as a versatile class of therapeutics with unique properties. More than 30 therapeutic antibodies are now approved in the United States and European Union, with numerous candidates filling the preclinical and clinical pipeline of every major pharmaceutical companies and biotechnology firms. Monoclonal antibodies have the advantage over traditional medicines in that they are able to specifically bind to the desired targets with little to no associated toxicity. In the recent years, monoclonal antibodies approved for oncology treatments have gained in notoriety and are now used as adjuvants or neo-adjuvants to radiotherapy, chemotherapy and surgery. In the field of head and neck cancer, the anti-EGF receptor antibody Erbitux has paved the way for new targeted treatments to SCCHN. This review introduces some basic concepts and recent perspectives on monoclonal antibodies with a focus on head and neck cancer treatments.


Head & Neck ◽  
1989 ◽  
Vol 11 (6) ◽  
pp. 511-515 ◽  
Author(s):  
Boudewijn J. M. Braakhuis ◽  
Guus A. M. S. Van Dongen ◽  
Marian Bagnay ◽  
Marijke Van Walsum ◽  
Gordon B. Snow

1999 ◽  
Vol 11 (3) ◽  
pp. 187 ◽  
Author(s):  
Richard H. Wheeler ◽  
Sharon Spencer ◽  
Donald Buchsbaum ◽  
Francisco Robert

2009 ◽  
Vol 11 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Steve C. Lee ◽  
Andrés López-Albaitero ◽  
Robert L. Ferris

1986 ◽  
Vol 54 (1) ◽  
pp. 53-59 ◽  
Author(s):  
G H Boerrigter ◽  
E C M Heinerman ◽  
B J M Braakhuis ◽  
G B Snow

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