Immunotherapy of murine leukemia. I. protection against friend leukemia virus-induced disease by passive serum therapy

1978 ◽  
Vol 21 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Jeffrey J. Collins ◽  
Fred Sanfilippo ◽  
Lynn Tsong-Chou ◽  
Ryo Ishizaki ◽  
Richard S. Metzgar
Keyword(s):  
Leukemia Virus ◽  
Friend Leukemia ◽  
Serum Therapy ◽  
Friend Leukemia Virus ◽  
Murine Leukemia

scholarly journals Influence of the murine MHC (H-2) on Friend leukemia virus-induced immunosuppression.

1986 ◽  
Vol 163 (2) ◽  
pp. 301-314 ◽  
Author(s):  
R P Morrison ◽  
J Nishio ◽  
B Chesebro
Keyword(s):  
T Lymphocyte ◽  
B Lymphocyte ◽  
Leukemia Virus ◽  
Friend Leukemia ◽  
Virus Complex ◽  
Plasma Antibody ◽  
Antibody Titers ◽  
Partial Suppression ◽  
Friend Leukemia Virus ◽  
Murine Leukemia

Friend murine leukemia virus complex (FV)-induced immunosuppression was studied by assaying splenic anti-SRBC PFC responses and plasma antibody titers in mice at various times after FV inoculation. Genes located within the H-2 complex were found to influence resistance to FV-induced immunosuppression. Near normal responses were observed in mice having the H-2a/b or H-2b/b genotype, whereas mice having the H-2a/a genotype were suppressed. This H-2 effect was observed not only in mice having heterozygous C57BL/10 X A background genes, including Rfv-3r/s, but also was apparent in mice having homozygous A-strain background genes, including Rfv-3s/s. Therefore, the Rfv-3 gene did not appear to convey resistance to FV-induced immunosuppression. The suppression in susceptible H-2a/a mice was characterized by a partial suppression of the IgM response and a profound suppression of both the primary and secondary IgG responses. Neither splenomegaly nor viremia alone appeared to be sufficient for the induction or maintenance of the immunosuppression. The mechanism of suppression was unclear, but both B lymphocyte and T lymphocyte functions appeared to be altered.

Recent Studies on a Murine Leukemia Virus Grown in Tissue Culture

1967 ◽  
Vol 25 ◽  
pp. 106-107
Author(s):  
L. Z. de Tkaczevski ◽  
E. de Harven ◽  
C. Friend
Keyword(s):  
Tissue Culture ◽  
Solid Tumors ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Supernatant Fluid ◽  
Virus Particles ◽  
Friend Leukemia ◽  
Type C ◽  
Leukemia Viruses ◽  
Murine Leukemia

Despite extensive studies, the correlation between the morphology and pathogenicity of murine leukemia viruses (MLV) has not yet been clarified. The virus particles found in the plasma of leukemic mice belong to 2 distinct groups, 1 or 2% of them being enveloped A particles and the vast majority being of type C. It is generally believed that these 2 types of particles represent different phases in the development of the same virus. Particles of type A have been thought to be an earlier form of type C particles. One of the tissue culture lines established from Friend leukemia solid tumors has provided the material for the present study. The supernatant fluid of the line designated C-1A contains an almost pure population of A particles as illustrated in Figure 1. The ratio is, therefore, the reverse of what is unvariably observed in the plasma of leukemic mice where C particles predominate.

Sign in / Sign up

Export Citation Format

Share Document