Immunotherapy of Murine Leukemia. V. Protection Against Friend Leukemia Virus-Induced Immune Complex Glomerulonephritis by Passive Serum Therapy23

1981 ◽  
Keyword(s):  
Immune Complex ◽  
Leukemia Virus ◽  
Immune Complex Glomerulonephritis ◽  
Friend Leukemia ◽  
Serum Therapy ◽  
Friend Leukemia Virus ◽  
Murine Leukemia

Immunotherapy of murine leukemia. I. protection against friend leukemia virus-induced disease by passive serum therapy

1978 ◽  
Vol 21 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Jeffrey J. Collins ◽  
Fred Sanfilippo ◽  
Lynn Tsong-Chou ◽  
Ryo Ishizaki ◽  
Richard S. Metzgar
Keyword(s):  
Leukemia Virus ◽  
Friend Leukemia ◽  
Serum Therapy ◽  
Friend Leukemia Virus ◽  
Murine Leukemia

scholarly journals THE VIRAL ENVELOPE GLYCOPROTEIN OF MURINE LEUKEMIA VIRUS AND THE PATHOGENESIS OF IMMUNE COMPLEX GLOMERULONEPHRITIS OF NEW ZEALAND MICE

1974 ◽  
Vol 140 (4) ◽  
pp. 1011-1027 ◽  
Author(s):  
Takashi Yoshiki ◽  
Robert C. Mellors ◽  
Mette Strand ◽  
J. T. August
Keyword(s):  
New Zealand ◽  
Immune Complex ◽  
Envelope Glycoprotein ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Viral Envelope ◽  
High Concentration ◽  
Immune Complex Glomerulonephritis ◽  
Viral Envelope Glycoprotein ◽  
Murine Leukemia

The use of monospecific antisera for the analysis by radioimmunoassay and immunofluorescence study of two major viral proteins, gp69/71 and p30 of murine leukemia virus, that could be of significance in the pathogenesis of immune complex glomerulonephritis of mice, particularly NZB and B/WF1 hybrid mice, yielded the following conclusions. A remarkably high concentration of viral envelope glycoprotein, gp69/71, was detected in the spleen and serum of New Zealand mice (NZB, NZW, B/WF1, and W/BF1); the concentration in the spleen was 10-fold greater than that found in AKR mice and 30-fold greater than that present in C57BL/6 mice. The gp69/71 was deposited along with bound immunoglobulins, apparently as an immune complex, in the diseased kidneys of mice, and the glomerular site and extent of deposition of gp69/71 was related to the severity of the glomerulonephritis. This study suggests that the pathogenesis of immune complex glomerulonephritis (and vasculitis) in mice is related to the expression of this specific viral envelope glycoprotein and to the host immune response to this protein.

scholarly journals Influence of the murine MHC (H-2) on Friend leukemia virus-induced immunosuppression.

1986 ◽  
Vol 163 (2) ◽  
pp. 301-314 ◽  
Author(s):  
R P Morrison ◽  
J Nishio ◽  
B Chesebro
Keyword(s):  
T Lymphocyte ◽  
B Lymphocyte ◽  
Leukemia Virus ◽  
Friend Leukemia ◽  
Virus Complex ◽  
Plasma Antibody ◽  
Antibody Titers ◽  
Partial Suppression ◽  
Friend Leukemia Virus ◽  
Murine Leukemia

Friend murine leukemia virus complex (FV)-induced immunosuppression was studied by assaying splenic anti-SRBC PFC responses and plasma antibody titers in mice at various times after FV inoculation. Genes located within the H-2 complex were found to influence resistance to FV-induced immunosuppression. Near normal responses were observed in mice having the H-2a/b or H-2b/b genotype, whereas mice having the H-2a/a genotype were suppressed. This H-2 effect was observed not only in mice having heterozygous C57BL/10 X A background genes, including Rfv-3r/s, but also was apparent in mice having homozygous A-strain background genes, including Rfv-3s/s. Therefore, the Rfv-3 gene did not appear to convey resistance to FV-induced immunosuppression. The suppression in susceptible H-2a/a mice was characterized by a partial suppression of the IgM response and a profound suppression of both the primary and secondary IgG responses. Neither splenomegaly nor viremia alone appeared to be sufficient for the induction or maintenance of the immunosuppression. The mechanism of suppression was unclear, but both B lymphocyte and T lymphocyte functions appeared to be altered.

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