Accuracy of 50-g glucose challenge test to detect International Association of Diabetes and Pregnancy Study Groups criteria-defined hyperglycemia

ABSTRACT Background To compare the sensitivity and specificity of fasting plasma glucose (FPG) with that of standard glucose challenge test (GCT). Materials and methods Eighty-nine eligible pregnant women underwent GCT between 24th and 28th gestational week, followed by a diagnostic 3 hours 100 gm oral glucose tolerance test within 1 week. Out patient clinic in Father Muller Medical College Hospital, Mangalore. Data was analyzed for significance by chi-square test. Results Fasting plasma glucose concentration at a threshold value of 90 mg/dl and GCT at recommended standard threshold of 140 mg/dl yielded sensitivities of 66.7% and 100% respectively and specificities of 87.3% and 46.5% respectively. Reducing the threshold value of FPG to 80 mg/dl increased the sensitivity of test to 91.7% with specificity of 54.9% which was comparable to standard GCT, in our study. Conclusion Measuring FPG concentration using a cut-off of. 80 mg/dl is an easier, tolerable and more cost effective procedure than GCT for detecting more severe cases of GDM, i.e. the diabetes mellitus group. In resource poor settings with population belonging to average risk or high risk category, FPG at a cut-off of 90 mg/dl can be used to screen GDM. How to cite this article Sham S, Bhat BPR, Kamath A. Comparative Study of Fasting Plasma Glucose Concentration and Glucose Challenge Test for Screening Gestational Diabetes Mellitus. J South Asian Feder Obst Gynae 2014;6(2):75-78.

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Pregnancy Outcomes in Women With and Without Gestational Diabetes Mellitus According to The International Association of the Diabetes and Pregnancy Study Groups Criteria

Obstetrics and Gynecology ◽

10.1097/aog.0b013e31826994ec ◽

2012 ◽

Vol 120 (4) ◽

pp. 746-752 ◽

Cited By ~ 53

Author(s):

Sonja Bodmer-Roy ◽

Lucie Morin ◽

Jocelyne Cousineau ◽

Evelyne Rey

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnancy Outcomes ◽

International Association ◽

Study Groups ◽

Diabetes And Pregnancy

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Glucose challenge test screening for prediabetes and undiagnosed diabetes

Diabetologia ◽

10.1007/s00125-009-1407-7 ◽

2009 ◽

Vol 52 (9) ◽

pp. 1798-1807 ◽

Cited By ~ 36

Author(s):

L. S. Phillips ◽

D. C. Ziemer ◽

P. Kolm ◽

W. S. Weintraub ◽

V. Vaccarino ◽

...

Keyword(s):

Challenge Test ◽

Undiagnosed Diabetes ◽

Glucose Challenge Test ◽

Glucose Challenge

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Clinical significance of second-trimester 50-g glucose challenge test among Japanese women diagnosed as normoglycemic after first-trimester 75-g glucose tolerance test

Taiwanese Journal of Obstetrics and Gynecology ◽

10.1016/j.tjog.2014.10.011 ◽

2016 ◽

Vol 55 (1) ◽

pp. 16-19 ◽

Cited By ~ 1

Author(s):

Mamoru Morikawa ◽

Takahiro Yamada ◽

Takashi Yamada ◽

Takashi Kojima ◽

Ryutaro Nishida ◽

...

Keyword(s):

Glucose Tolerance ◽

Clinical Significance ◽

Glucose Tolerance Test ◽

Challenge Test ◽

First Trimester ◽

Tolerance Test ◽

Japanese Women ◽

Second Trimester ◽

Glucose Challenge Test ◽

Glucose Challenge

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Challenging the Glucose Challenge Test

Obstetrical & Gynecological Survey ◽

10.1097/ogx.0b013e31823383e5 ◽

2011 ◽

Vol 66 (7) ◽

pp. 394-396

Author(s):

Jenny Huynh ◽

Sujiva Ratnaike ◽

Catherine Bartalotta ◽

Michael Permezel ◽

Christine Houlihan

Keyword(s):

Challenge Test ◽

Glucose Challenge Test ◽

Glucose Challenge

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The application of 50g oral glucose challenge test in screening for gestational diabetes mellitus in patients attending antenatal care OPD

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20171955 ◽

2017 ◽

Vol 6 (5) ◽

pp. 1952

Author(s):

Disha Andhiwal Rajput ◽

Jaya Kundan Gedam

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Plasma Glucose ◽

Gestational Hypertension ◽

Challenge Test ◽

Oral Glucose ◽

Average Risk ◽

Glucose Challenge Test ◽

Glucose Challenge

Background: To screen patients at average risk for Gestational Diabetes using 50g Glucose Challenge test, to ascertain the prevalence of Gestational diabetes through further diagnostic testing and to prevent and manage complications. Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity with onset or first recognition during pregnancy. Women with GDM are at risk for maternal and foetal complications, so it is important to screen all the pregnant woman.Methods: This study was conducted in 198 patients between 24 and 28 weeks of gestation, attending the Antenatal clinic. 50g oral glucose is administered irrespective of time of the last meal and plasma glucose is measured one hour later. Patients with plasma glucose levels more than 140 mg/dl were subjected to a 100g oral glucose tolerance test, patients with two or more abnormal reading were labelled as GDM and managed accordingly.Results: Prevalence of GDM in our study was 9.59%. Maternal complications like gestational hypertension, vaginal infections and foetal complications were much higher in GDM patients as compare to non GDM group.Conclusions: GDM is a disease which adversely affects both mother as well as foetus. It is concluded that 50 gm glucose challenge test at 24-28 weeks of gestation with a cut-off value of 140 mg/dl is a reliable screening test for GDM. This test offers the best combination of ease and economy of use and reproducibility in screening for gestational diabetes mellitus in average risk patients.

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